Results 101 to 110 of about 4,686 (201)
British Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li +9 more
wiley +1 more source
, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
core +2 more sources
Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie
Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl +6 more
wiley +1 more source
Discovery Methodology of Novel Conotoxins from Conus Species
Marine Drugs, 2018 Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but
Ying Fu +5 more
doaj +1 more source
Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. [PDF]
, 2013 The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series.
A. D. Rodriguez +3 more
core +2 more sources
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl +6 more
wiley +1 more source
Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels [PDF]
, 2013 Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy
Klugbauer, Norbert +5 more
core +4 more sources
Challenging the catechism of therapeutics for chronic neuropathic pain: targeting CaV2.2 interactions with CRMP2 peptides [PDF]
, 2013 Chronic neuropathic pain management is a worldwide concern. Pharmaceutical companies globally have historically targeted ion channels as the therapeutic catechism with many blockbuster successes.
Feldman, Polina, Khanna, Rajesh
core +1 more source
Frontiers in Cellular Neuroscience, 2017 Transcripts for α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are found in diverse tissues. The function of α9α10 nAChRs is best known in mechanosensory cochlear hair cells, but elsewhere their roles are less well-understood.
Sean B. Christensen +11 more
doaj +1 more source
Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]
, 2017 Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos +11 more
core +3 more sources