Regulation of the human cathepsin E gene by the constitutive androstane receptor [PDF]
Archives of Biochemistry and Biophysics, 2007 Cathepsin E (CTSE) is an aspartic protease that has been linked to antigen processing and innate immunity. Elevated levels of CTSE expression have also been associated with several forms of cancer, including carcinomas exhibiting highly invasive character.
Curtis J. Omiecinski +2 more
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A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes:Regulation by the Constitutive Androstane Receptor [PDF]
, 2013 The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug-drug interaction and should be assessed as early as possible in preclinical drug development.
Henderson, Colin J. +5 more
core +6 more sources
Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. [PDF]
Drug Metab Dispos, 2021 UDP-glucuronosyltransferase (UGT) 1A1 is the only transferase capable of conjugating serum bilirubin. However, temporal delay in the development of the UGT1A1 gene leads to an accumulation of serum bilirubin in newborn children.
Weber AA +6 more
europepmc +2 more sources
Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor [PDF]
Environmental Health Perspectives, 2018 Background: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at ...
Céline Lukowicz +18 more
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Constitutive androstane receptor (CAR) functions as a tumor suppressor via regulating stemness in liver cancer [PDF]
Scientific ReportsConstitutive androstane receptor (CAR) is a xenosensor that is almost exclusively expressed in the liver. Studies in rodents suggest an oncogenic role for CAR in liver cancer, but its role in human liver cancer is unclear.
Sarah Da Won Bae +5 more
doaj +2 more sources
Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor [PDF]
Molecular MetabolismObjective: The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise with the increasing obesity epidemic. Rezdiffra as an activator of a thyroid hormone receptor-beta is the only Food and Drug Administration ...
Xiao Cheng +10 more
doaj +2 more sources
NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in hUGT1 Mice. [PDF]
Drug Metab Dispos, 2020 Environmental toxicants such as heavy metals from contaminated water or soil and isothiocyanates (ITC) from dietary sources act as pro-oxidants by directly generating reactive oxygen species (ROS) or through depleting cellular antioxidants such as ...
Paszek M, Tukey RH.
europepmc +2 more sources
PLoS ONE, 2019 The regulation of cytochrome P450 3A (CYP3A) enzymes is established in humans, but molecular mechanisms of its basal and xenobiotic-mediated regulation in cattle are still unknown.
Mery Giantin +10 more
doaj +2 more sources
Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2 [PDF]
Toxicological Sciences, 2018 Exposure to environmentally relevant chemicals that activate the xenobiotic receptors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and peroxisome proliferator-activated receptor alpha (PPARα) in rodent test systems often leads
John P. Rooney +4 more
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Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR). [PDF]
Acta Pharm Sin B, 2021 Cai X, Feng Y, Xu M, Yu C, Xie W.
europepmc +2 more sources