Results 71 to 80 of about 45,599 (229)

CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders

Cells, 2023
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting 70–90% of obese individuals. In humans, a lower NAFLD incidence is reported in pre-menopausal women, although the mechanisms affording this ...
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Véronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal   +8 more
doaj   +1 more source

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs [PDF]

, 2007
A series of acetaminophen (APAP) analogs, 2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(4-hydroxyphenyl)alkanecarboxamides, bearing a heterocyclic moiety linked to the p-acylaminophenol fragment, were prepared in a general project to develop APAP ...
Bazan, Nicolas G., Marcheselli, Victor L., Matía Martín, Ma de la Paz, Minguez Ortega, José Miguel, Mukherjee, Pranab K., Paul, Dennis, Rodríguez de Turco, Elena B., Sunkel Letelier, Carlos, Trudell, Mark L., Vaccarino, Anthony L., Xu, Liang, Álvarez-Builla Gómez, Julio   +11 more
core   +3 more sources

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

Sensors, 2015
The constitutive androstane receptor (CAR) is a critical nuclear receptor in the gene regulation of xenobiotic and endobiotic metabolism. The LanthaScreenTM TR-FRET CAR coactivator assay provides a simple and reliable method to analyze the affinity of a ...
Alejandro Carazo, Petr Pávek
doaj   +1 more source

Regulation of biotransformation systems and ABC transporters by Benznidazole in HepG2 cells: involvement of Pregnane X-Receptor [PDF]

, 2012
Background: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet.
Arias, Agostina, Catania, Viviana Alicia, Luquita, Marcelo Gabriel, Mottino, Aldo Domingo, Perdomo, Virginia, Rigalli, Juan Pablo, Ruiz, Maria Laura, Theile, Dirk, Villanueva, Silvina Stella Maris, Weiss, Johanna   +9 more
core   +2 more sources

Antiepileptic Drug–Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator–Activated Receptor α and Peroxisome Proliferator–Activated Receptor γ Coactivator 1α–Dependent Gene Expression to Increase Blood Triglyceride Levels

Molecular Pharmacology, 2020
Long-term administration of some antiepileptic drugs often increases blood lipid levels. In this study, we investigated its molecular mechanism by focusing on the nuclear receptors constitutive active/androstane receptor (CAR) and peroxisome proliferator–
R. Shizu, Yuta Otsuka, Kanako Ezaki, Chizuru Ishii, Shingo Arakawa, Yuto Amaike, Taiki Abe, T. Hosaka, Takamitsu Sasaki, Yuichiro Kanno, M. Miyata, Y. Yamazoe, K. Yoshinari   +12 more
semanticscholar   +1 more source

Induction of bilirubin clearance by the constitutive androstane receptor (CAR) [PDF]

Proceedings of the National Academy of Sciences, 2003
Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is particularly common in neonates. Elevated bilirubin levels can be decreased by treatment with phenobarbital. Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this ...
W. HUANG, J. ZHANG, S. S. CHUA, M. QATANANI, Y. HAN, GRANATA, Riccarda, D. D. MOORE   +6 more
openaire   +3 more sources

The Nuclear Receptor PXR in Chronic Liver Disease

Cells, 2021
Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P-glycoprotein, is functionally involved in chronic liver diseases of different ...
Katia Sayaf, Ilaria Zanotto, Francesco Paolo Russo, Daniela Gabbia, Sara De Martin   +4 more
doaj   +1 more source

In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]

, 2011
Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Ekstrand, Bo, Rasmussen, Martin Krøyer, Zamaratskaia, Galia   +2 more
core   +1 more source