Results 71 to 80 of about 3,898 (208)
Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
core +1 more source
Frontiers in Marine Science, 2021 Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Han Zhang +18 more
doaj +1 more source
Bioactive Mimetics of Conotoxins and other Venom Peptides
Toxins, 2015 Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode
Peter J. Duggan, Kellie L. Tuck
doaj +1 more source
Diversity and Distributions, Volume 31, Issue 8, August 2025.ABSTRACT Aim Tropicalisation and other climate‐induced range shifts are rapidly restructuring global biodiversity patterns. The detection of range shifts is often complex and requires big‐data approaches. Environmental DNA (eDNA) monitoring is emerging as a powerful method for assessing biodiversity changes at unprecedented spatial and temporal ...
Karolina M. Zarzyczny +8 more
wiley +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2008 The protein-containing extracts prepared from the venom ducts of Conus austini, Conus spurius and Polystira albida caused a concentration-dependent inhibition of spontaneous contractions in guinea pig ileum.
A Rojas +5 more
doaj +1 more source
Status of Bioprospecting of Marine Molluscs in India [PDF]
, 2010 Continuous pressure on the environment arising inevitably or otherwise out of technological progress and human population growth has made it necessary to place a commodity value on biodiversity (Randall, 1991)
Mohamed, K S +4 more
core
Friends or Foes? Emerging Impacts of Biological Toxins [PDF]
, 2019 Toxins are substances produced from biological sources (e.g., animal, plants, microorganisms) that have deleterious effects on a living organism. Despite the obvious health concerns of being exposed to toxins, they are having substantial positive impacts
Casewell, N.R. +6 more
core +6 more sources
Journal of Peptide Science, Volume 31, Issue 6, June 2025.This study cyclized conotoxin Vc1.1 using polyethylene glycol (PEG) linkers of different lengths and demonstrates that linker length modulates the peptide's helicity, thereby influencing its biological activity and stability. ABSTRACT α‐Conotoxin Vc1.1 is a disulfide‐rich peptide and a promising drug candidate for treating neuropathic and chronic pain.
Yuhui Zhang +4 more
wiley +1 more source
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.
Marine Drugs, 2016 Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe +9 more
doaj +1 more source
Structural information in therapeutic peptides: Emerging applications in biomedicine
FEBS Open Bio, Volume 15, Issue 2, Page 254-268, February 2025.Peptides are increasingly popular as therapeutic agents due to their cost‐effectiveness, low immune response, and high specificity. Many tools study peptides as linear chains, ignoring crucial structural details that affect their properties. Recent advances in peptide structure prediction have improved our understanding.
Valentín Iglesias +4 more
wiley +1 more source