Results 81 to 90 of about 3,898 (208)
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]
, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B +11 more
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British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane +9 more
wiley +1 more source
Venomous mollusks: the risks of human accidents by conus snails (gastropoda: conidae) in Brazil [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2006 Mollusks of the genus Conus present a venomous apparatus composed of radulae, a chitin structure linked to glands, which injects potent neurotoxic peptides, causing serious human envenomation and even death, associated with the blockage of certain receptors and muscular paralysis. No reported envenomation has occurred in Brazil, but certain populations
Haddad Júnior, Vidal +2 more
openaire +6 more sources
A New Pain Killer from the Nature: N-Type Calcium Channels Blockers
Proceedings, 2020 N-type calcium channels (Neuronal-type Calcium channel, Cav2.2) is a member of high voltage activated calcium channels. There are two native small peptides for N-type calcium channels (NTCC) directly which are derived from cone snail, ω-conotoxin ...
Leen Othman, Emre Hamurtekin
doaj +1 more source
Three-Dimensional Structure of Conotoxin tx3a: A m-1 Branch Peptide of the M-Superfamily [PDF]
, 2008 The M-superfamily, one of eight major conotoxin superfamilies found in the venom of the cone snail, contains a Cys framework with disulfide-linked loops labeled 1, 2, and 3 (- CC1C2C3CC-). M-superfamily conotoxins can be divided into the m-1, -2, -3 and -
McDougal, Owen M. +3 more
core +1 more source
Sequence similarity in structurally dissimilar proteins [PDF]
, 1915 Digitalitzat per ...
Tomiuk, Stefan, Hofmann, Kay
core +1 more source
Eocene gastropods of the New Forest, UK
Geology Today, Volume 41, Issue 1, Page 26-37, January/February 2025.Gastropods expanded into niches vacated by both terrestrial and marine organisms following the end‐Cretaceous mass extinction, to become one of the dominant mollusc groups of the Cenozoic. The Selsey Formation of Eocene age was deposited within a shallow marine embayment across the Hampshire Basin (southern England) and contains a particularly diverse ...
James Barnet
wiley +1 more source
Less is more: Design of a highly stable disulfide-deleted mutant of analgesic cyclic alpha-conotoxin Vc1.1 [PDF]
, 2015 Cyclic alpha-conotoxin Vc1.1 (cVc1.1) is an orally active peptide with analgesic activity in rat models of neuropathic pain. It has two disulfide bonds, which can have three different connectivities, one of which is the native and active form.
Adams, D +7 more
core +3 more sources
Prey specificity of predatory venoms
Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek +2 more
wiley +1 more source
DIFFERENCES IN RESTING-SITE PREFERENCE IN TWO COEXISTING LAND SNAILS, ARIANTA ARBUSTORUM AND ARIANTA CHAMAELEON (HELICIDAE), ON ALPINE SLOPES [PDF]
, 2017 Resting-site preference and patterns of spatial distribution were examined in the sympatric land snails Arianta arbustorum and A. chamaeleon on two opposite slopes in the south-eastern Alps, Austria.
BAMINGER, HELMUT +5 more
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