Results 61 to 70 of about 3,898 (208)

The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII [PDF]

, 2001
The alpha-conotoxin MII is a 16 amino acid long peptide toxin isolated from the marine snail, Conus magus. This toxin has been found to be a highly selective and potent inhibitor of neuronal nicotinic acetylcholine receptors of the subtype alpha3beta2 ...
Adams, D. J., Alewood, P., Blanchfield, Joanne T., Craik, D. J., Dutton, Julie T., Hogg, R. C., Lewis, R. J., Toth, I.   +7 more
core   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Graman Revisited Once Again: A Reanalysis of the Late Holocene Legacy Faunal Assemblage From GB4 Rockshelter, New South Wales

Archaeology in Oceania, Volume 61, Issue 1, Page 199-220, April 2026.
ABSTRACT The archaeological site Graman B4 provided one of the first records of substantial dietary change in ancient Australian Aboriginal society. Initial examination of the faunal remains from this site suggested that Late Holocene hunters reduced their focus on high‐ranked kangaroos to increasingly rely on arboreal possums; and that these ...
Loukas George Koungoulos, Jane Balme, Sue O'Connor   +2 more
wiley   +1 more source

Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom

Toxins, 2016
Lung cancer is one of the most common types of cancer in men and women and a leading cause of death worldwide resulting in more than one million deaths per year.
Irasema Oroz-Parra, Mario Navarro, Karla E. Cervantes-Luevano, Carolina Álvarez-Delgado, Guy Salvesen, Liliana N. Sanchez-Campos, Alexei F. Licea-Navarro   +6 more
doaj   +1 more source

Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]

, 2018
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Favreau, P., Koua, D., Olivera, B., Puillandre, N., Stöcklin, R.   +4 more
core  

A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties [PDF]

, 2015
Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence ...
Aleksandra eWalewska, Aleksandra eWalewska, Baldomero M Olivera, Grzegorz eBulaj, H Steve eWhite, Hee-Kyoung eLee, J Michael eMcIntosh, Liuyin eZhang, Misty D Smith, Nadeem eVellore, Riccardo eBaron   +10 more
core   +2 more sources

Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats

Journal of Venomous Animals and Toxins including Tropical Diseases, 2014
Background:Calcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitromodels of brain and spinal cord ischemia suggest a potential role of this toxin ...
Karen M Oliveira, Carla Maria O Silva, Mário Sérgio L Lavor, Isabel R Rosado, Fabíola B Fukushima, Anna Luiza FV Assumpção, Saira MN Neves, Guilherme R Motta, Fernanda F Garcia, Marcus Vinícius Gomez, Marília M Melo, Eliane G Melo   +11 more
doaj   +1 more source

Analysis of a cone snail's killer cocktail – The milked venom of Conus geographus [PDF]

Toxicon, 2012
"Snails can kill" is a statement that receives much disbelief. Yet the venom from Conus geographus, as delivered by a disposable hypodermic-like needle, has indeed killed many unsuspecting human victims. Our understanding of their milked venom the essence of these fatalities, is in itself non-existent.
Jon-Paul, Bingham, Margaret R, Baker, Joycelyn B, Chun   +2 more
openaire   +2 more sources

Novel conopeptides of largely unexplored Indo Pacific Conus sp. [PDF]

, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
D'Souza, L., De Mot, R., Devi, P., Ghequire, M.G.K., Lebbe, E.K.M., Mille, B.G., Peigneur, S., Ravichandran, S., Tytgat, J., Waelkens, E.   +9 more
core  

Refuge trifecta: intertidal gastropods use pits to escape heat, wave action and predation

Oikos, Volume 2025, Issue 10, October 2025.
Refuges play a critical role in ecology and evolution. In hard intertidal shores, small pits attract benthic invertebrates such as gastropods, however, there exists little mechanistic understanding of the processes driving the active usage of these microhabitat features. We conducted a series of laboratory experiments to assess whether the marine snail
Joel W. Q. Tan, Janine Ledet, Peter A. Todd   +2 more
wiley   +1 more source