Results 41 to 50 of about 15,951 (206)

Transfer of Dietary Coenzyme Q10 into the Egg Yolk of Laying Hens

The Journal of Poultry Science, 2010
Coenzyme Q10 (CoQ10), a potent lipophilic antioxidant, is a naturally occurring compound with a ubiquitous distribution in nature, and CoQ10 is used as a dietary supplement to combat aging.
Hiroshi Kamisoyama, Kazuhisa Honda, Kanako Kitaguchi, Shin Hasegawa   +3 more
doaj   +1 more source

Cochlear injury and adaptive plasticity of the auditory cortex [PDF]

, 2015
Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex.
Fetoni, Ar, Paludetti, G., Petrosini, Laura, Troiani, D   +3 more
core   +2 more sources

Coenzyme Q10 and Neurological Diseases

Pharmaceuticals, 2009
Coenzyme Q10 (CoQ10, or ubiquinone) is a small electron carrier of the mitochondrial respiratory chain with antioxidant properties. CoQ10 supplementation has been widely used for mitochondrial disorders.
Gabriele Siciliano, Anna Choub, Michelangelo Mancuso, Daniele Orsucci, Valeria Calsolaro   +4 more
doaj   +1 more source

Metabolic flux analysis of coenzyme Q10 synthesized by Rhodobacter sphaeroides under the influence of different pH regulators

Microbial Cell Factories, 2023
Coenzyme Q10 (CoQ10) is crucial for human beings, especially in the fields of biology and medicine. The aim of this experiment was to investigate the conditions for increasing CoQ10 production.
Yujun Xiao, Yi Zheng, Yong Zhou, Chaofan Yu, Ting-E Ye   +4 more
doaj   +1 more source

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source

Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes

Biological Research
BACKGROUND: Coenzyme Q10 (CoQ10 or ubiquinone) deficiency can be due either to mutations in genes involved in CoQ10 biosynthesis pathway, or to mutations in genes unrelated to CoQ10 biosynthesis.
Konstantina Fragaki, Annabelle Chaussenot, Jean-François Benoist, Samira Ait-El-Mkadem, Sylvie Bannwarth, Cécile Rouzier, Charlotte Cochaud, Véronique Paquis-Flucklinger   +7 more
doaj   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations

Redox Biology, 2020
Coenzyme Q10 (CoQ10; also known as ubiquinone) is a vital, redox-active membrane component that functions as obligate electron transporter in the mitochondrial respiratory chain, as cofactor in other enzymatic processes and as antioxidant.
Ying Wang, Siegfried Hekimi
doaj   +1 more source

Interaction of Coenzyme Q10 with Liposomes and its Impact on Suppression of Selenite – Induced Experimental Cataract [PDF]

Advanced Pharmaceutical Bulletin, 2018
Purpose: To stress the influence of Coenzyme Q10 (CoQ10) on the structural properties of liposomes as model membranes and to investigate the possible role of CoQ10 or CoQ10 doped in liposomes when topically instilled as eye drops, in preventing cataract.
Medhat Wahba Shafaa, Amany Hasan Elshazly, Amira Zaki Dakrory, Maha Reda Elsyed   +3 more
doaj   +1 more source