Results 51 to 60 of about 15,919 (216)

Response of an Infant With Presumed Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) to Ketone Supplementation

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in one of three known genes: ETFA, ETFB, and ETFDH. It can cause multisystem dysfunction, including cardiomyopathy in severe cases.
Yutaka Furuta, Kaitlyn N. Bloom, Jerry Vockley, Angela R. Grochowsky, Neena S. Agrawal, Ellen W. Strickler, Natalie N. Owen, Erica T. Gray, B. Lakshitha A. Perera, Eric R. Gamazon, Lynette C. Rives, Hua‐Chang Chen, Qi Liu, Rizwan Hamid, Joy D. Cogan, John A. Phillips III, Thomas A. Cassini, Bryce A. Schuler   +17 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Impact of Coenzyme Q10 Supplementation on Skeletal Muscle Respiration, Antioxidants, and the Muscle Proteome in Thoroughbred Horses

Antioxidants, 2023
Coenzyme Q10 (CoQ10) is an essential component of the mitochondrial electron transfer system and a potent antioxidant. The impact of CoQ10 supplementation on mitochondrial capacities and the muscle proteome is largely unknown.
Marisa L. Henry, Lauren T. Wesolowski, Joe D. Pagan, Jessica L. Simons, Stephanie J. Valberg, Sarah H. White-Springer   +5 more
doaj   +1 more source

Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice [PDF]

, 2014
Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose
Clark, Yvonne, McCarthy, Donna O., Szalacha, Laura A., Wold, Loren E.   +3 more
core   +2 more sources

Coenzyme Q10 and embryonic development: a potential role in reproductive medicine

Акушерство, гинекология и репродукция
Maternal mitochondria provide energy to the embryo through oxidative phosphorylation before blastocyst implantation, where intracellular energy is mainly supplied by glycolysis.
A. U. Khamadyanova, R. M. Mannanov, D. M. Smakova, F. I. Musaeva, D. G. Bedelov, A. E. Ibragimov, A. A. Rusinova, M. M. Salikhova, S. V. Shtukaturova, T. V. Doroshenko, M. V. Fattakhova, M. K. Rakhimova, L. R. Marinova   +12 more
doaj   +1 more source

Phosphate limitation increases coenzyme Q10 production in industrial Rhodobacter sphaeroides HY01

Synthetic and Systems Biotechnology, 2019
Coenzyme Q10 (CoQ10) is an important component of the respiratory chain in humans and some bacteria. As a high-value-added nutraceutical antioxidant, CoQ10 has excellent capacity to prevent cardiovascular disease.
Lu Zhang, Leshi Liu, Ke-Feng Wang, Lan Xu, Liming Zhou, Weishan Wang, Chuan Li, Zheng Xu, Tong Shi, Haihong Chen, Yuanhang Li, Hui Xu, XiuLiang Yang, Zhichun Zhu, Biqin Chen, Dan Li, Guanghuang Zhan, Si-Liang Zhang, Li-Xin Zhang, Gao-Yi Tan   +19 more
doaj   +1 more source

Interaction of Coenzyme Q10 with Liposomes and its Impact on Suppression of Selenite – Induced Experimental Cataract [PDF]

Advanced Pharmaceutical Bulletin, 2018
Purpose: To stress the influence of Coenzyme Q10 (CoQ10) on the structural properties of liposomes as model membranes and to investigate the possible role of CoQ10 or CoQ10 doped in liposomes when topically instilled as eye drops, in preventing cataract.
Medhat Wahba Shafaa, Amany Hasan Elshazly, Amira Zaki Dakrory, Maha Reda Elsyed   +3 more
doaj   +1 more source

Involvement of NADH Oxidase in Biofilm Formation in Streptococcus sanguinis [PDF]

, 2016
Biofilms play important roles in microbial communities and are related to infectious diseases. Here, we report direct evidence that a bacterial nox gene encoding NADH oxidase is involved in biofilm formation. A dramatic reduction in biofilm formation was
Ge, Xiuchun, Kitten, Todd, Kong, Fanxiang, Liu, Jinlin, Shi, Limei, Shi, Xiaoli, Stone, Victoria, Xu, Ping   +7 more
core   +3 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Protective Effect of Coenzyme Q10 on Methamphetamine-Induced Apoptosis in Adult Male Rats

Novelty in Biomedicine, 2017
Background: The negative consequence of methamphetamine abuse is due to neuropathologic changes in the brain, which reduces dopaminergic neurons and result in damage to different brain areas.
Fatemeh Gholipour, Jamal Shams, Alireza Zahiroddin   +2 more
doaj   +1 more source