Results 51 to 60 of about 9,756 (188)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Metabolomics Analysis Revealed That SXZ Ameliorates Cognitive Impairment in Naturally Aged Rats by Promoting Glutathione Metabolism and Inhibiting the Ferroptosis Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In aged rats, 6‐month SXZ treatment reversed spatial memory deficits and preserved hippocampal integrity. Mechanistic assays show that SXZ promotes glutathione metabolism and inhibits ferroptosis via p53/SLC7A11/GPX4 and Keap1/Nrf2/HO‐1 pathways. SXZ is a novel neuroprotective agent against age‐related cognitive decline.
Mengya Liu, Shunyi Li, Yonglin Liang, Yugui Zhang, Xutong Jia, Yongqiang Duan, Min Bai   +6 more
wiley   +1 more source

The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Therapeutics and Clinical Risk Management, 2019
Nazanin Zahrooni,1 Seyed Ahmad Hosseini,2 Ahmad Ahmadzadeh,3 Kambiz Ahmadi Angali,4 Mohammad Ali Assarehzadegan5 1Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Nutrition and Metabolic ...
Zahrooni N, Hosseini SA, Ahmadzadeh A, Ahmadi Angali K, Assarehzadegan MA   +4 more
doaj  

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats [PDF]

Eurasian Journal of Veterinary Sciences
Aim: This study was conducted to evaluate the effects of Coenzyme Q10 on some hematological parameters in streptozotocin-induced diabetic rats. Materials and Methods: In the experiment, 38 healthy, adult male rats were divided into five groups.
Ercan Keskin, Deniz Uluışık
doaj  

Coenzyme Q 10: multiple benefits in one ingredient

Oléagineux, Corps gras, Lipides, 2011
Coenzyme Q is a lipid molecule widely diffused in nature; in humans and other mammals it is present as coenzyme Q10. (CoQ10). The first recognized role of CoQ10 was in mitochondrial bioenergetics, where it plays a central role in the production of ATP ...
Littarru Gian Paolo, Lambrechts Peter
doaj   +1 more source

Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals

Journal of the International Society of Sports Nutrition, 2008
Background To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals.
Leutholtz Brian, Greenwood Mike, Rasmussen Christopher, Kerksick Chad, Hudson Geoffrey, Shelmadine Brian, Buford Thomas, Iosia Mike, Cooke Matthew, Willoughby Darryn, Kreider Richard   +10 more
doaj   +1 more source

Small Molecule Therapeutic Approaches With a Greater Focus on Hearing Loss: A Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Hearing loss (HL) is one of the most common sensory impairments worldwide and has substantial effects on quality of life and daily functioning. Although cochlear implants and hearing aids have markedly improved the management of hearing impairment, these devices do not directly address the underlying pathogenic mechanisms ...
Maryam Naghinejad, Farzaneh Motallebi, Elaheh Hasani, Moein Kohkalani, Sepideh Parvizpour, Sima Mansoori Derakhshan   +5 more
wiley   +1 more source

Evolutionary clues unlock CoQ10 biofortification

Trends in Plant Science
Coenzyme Q (CoQ) is vital for human health, but structural differences limit its supplementation from crops. In a recent study, Xu et al. traced its diversification across plant lineages and identified distinct targets for precise engineering. Their work highlights how utilising evolutionary signatures can enable crop biofortification and guide future ...
Florian Hänsel, Goetz Hensel
openaire   +2 more sources

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source