Results 61 to 70 of about 15,919 (216)

Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations

Redox Biology, 2020
Coenzyme Q10 (CoQ10; also known as ubiquinone) is a vital, redox-active membrane component that functions as obligate electron transporter in the mitochondrial respiratory chain, as cofactor in other enzymatic processes and as antioxidant.
Ying Wang, Siegfried Hekimi
doaj   +1 more source

The Effect of Coenzyme Q10 on Liver Injury Induced by Valproic Acid and Its Antiepileptic Activity in Rats

Biomedicines, 2022
Valproic acid (VPA) has toxic metabolites that can elevate oxidative stress markers, and the hepatotoxicity of VPA has been reported. Coenzyme Q10 (CoQ10) is one of the most widely used antioxidants.
Fahad Alqarni, Hala S. Eweis, Ahmed Ali, Aziza Alrafiah, Mohammed Alsieni, Shahid Karim, Mosleh Ayed Alkathyri   +6 more
doaj   +1 more source

Assessing the influence of the carbon source on the abatement of industrial N2O emissions coupled with the synthesis of added-value bioproducts [PDF]

, 2017
Producción CientíficaThe continuous abatement of a synthetic N2O emission from a nitric acid plant coupled with the simultaneously production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) copolymer and the coenzyme Q10 (CoQ10) in a bubble column
Barriguín García, Gonzalo, Frutos, Osvaldo D., Lebrero Fernández, Raquel, Muñoz Torre, Raúl   +3 more
core   +2 more sources

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia? [PDF]

, 2013
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM.
Alfonsi, Simona, Bullon, Pedro, Carrión, Ángel Manuel, Cordero, Mario D., Díaz-Parrado, Eduardo, Sánchez Alcázar, José Antonio   +5 more
core  

Agrimoniin Alleviates Ferroptosis in Cold‐Stored DCD Liver Grafts Through Activation of the Nrf‐2 Pathway

Cell Proliferation, EarlyView.
Supplementing the liver preservation solution with agrimoniin protects donation after cardiac death (DCD) grafts by activating the Nrf‐2 pathway. This reduces ferroptosis, oxidative stress, and inflammation during cold storage, significantly improving graft viability.
Enqiang Chang, Xiaoting Liao, Guanghua Tao, Bijun Luo, Sheng He, Linghui Pan   +5 more
wiley   +1 more source

CoenzymeQ10 and Ischemic Preconditioning Potentially Prevent Tourniquet-Induced Ischemia/Reperfusion in Knee Arthroplasty, but Combined Pretreatment Possibly Neutralizes Their Beneficial Effects

Antioxidants, 2022
Tourniquet (TQ) use during total knee arthroplasty (TKA) induces ischemia/reperfusion (I/R) injury, resulting in mitochondrial dysfunction. This study aims to determine the effects of coenzyme Q10 (CoQ10) and ischemic preconditioning (IPC), either alone ...
Prangmalee Leurcharusmee, Passakorn Sawaddiruk, Yodying Punjasawadwong, Nantawit Sugundhavesa, Kasisin Klunklin, Siam Tongprasert, Patraporn Sitilertpisan, Thidarat Jaiwongkam, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn   +10 more
doaj   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Prophylactic Effectiveness of Coenzyme Q10 for Migraine in Adults: A Systematic Review and Meta-Analysis of Double-Blinded Randomized Clinical Trials

Traditional and Integrative Medicine
We aimed to evaluate the influence of coenzyme Q10 alone (CoQ10) or in association with other nutraceuticals (CoQ10+) on the frequency, severity, duration of migraine attacks, and quality of life. We conducted a meta-analysis and a network meta-analysis
Emna Ellouz, Imen Ketata
doaj   +1 more source

Coenzyme Q10 deficiencies: pathways in yeast and humans. [PDF]

, 2018
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.
Awad, Agape M, Bradley, Michelle C, Clarke, Catherine F, Fernández-Del-Río, Lucía, Nag, Anish, Tsui, Hui S   +5 more
core