Results 1 to 10 of about 869,007 (330)
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands [PDF]
Nature Communications, 2021 Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of ...
Roza H. Ali Masalmeh +13 more
doaj +3 more sources
Intragenic CpG Islands and Their Impact on Gene Regulation. [PDF]
Front Cell Dev Biol, 2022 The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated with gene promoters ...
Cain JA, Montibus B, Oakey RJ.
europepmc +8 more sources
Keep Fingers on the CpG Islands [PDF]
EpigenomesThe post-genomic era has ushered in the extensive application of epigenetic editing tools, allowing for precise alterations of gene expression. The use of reprogrammable editors that carry transcriptional corepressors has significant potential for long ...
Xing Zhang +2 more
doaj +4 more sources
Sequence determinants, function, and evolution of CpG islands. [PDF]
Biochem Soc Trans, 2021 In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with ∼80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with long-term gene silencing. The exceptions to such a globally hypermethylated
Angeloni A, Bogdanovic O.
europepmc +2 more sources
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1996 Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes such as the regulation of imprinted genes, X chromosome inactivation, and tumor suppressor gene silencing in human cancer.
James G. Herman +4 more
openalex +2 more sources
CpG islands and the regulation of transcription. [PDF]
Genes & Development, 2011 Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated.
A. Deaton, A. Bird
semanticscholar +5 more sources
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness. [PDF]
Nat Genet, 2021 CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being associated with ~70% of all gene promoters. CGIs control transcription initiation by conferring nearby promoters with unique chromatin properties.
Pachano T +12 more
europepmc +2 more sources
The Role of H3K4 Trimethylation in CpG Islands Hypermethylation in Cancer [PDF]
Biomolecules, 2021 CpG methylation in transposons, exons, introns and intergenic regions is important for long-term silencing, silencing of parasitic sequences and alternative promoters, regulating imprinted gene expression and determining X chromosome inactivation ...
Giuseppe Zardo
doaj +2 more sources
CpG island mapping by epigenome prediction. [PDF]
PLoS Computational Biology, 2007 CpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by simple DNA sequence criteria, which allowed for genome ...
Christoph Bock +3 more
doaj +6 more sources
Comparative analysis of CpG islands among HBV genotypes. [PDF]
PLoS ONE, 2013 DNA methylation is being increasingly recognized to play a role in regulation of hepatitis B virus (HBV) gene expression. The aim of this study was to compare the CpG island distribution among different HBV genotypes.
Yongmei Zhang +11 more
doaj +2 more sources