Results 1 to 10 of about 28,422 (165)
Genome Research, 1997 We describe an analysis of the CpG islands (CGIs) of the pig. We have used both database survey and a porcine genomic library that is enriched for CGIs. Approximately half of 41 pig genomic database sequences had CGIs with an average G + C content of 65.3%, an average CpG observed/expected frequency of 0.85, and an average size of 978 bp.
McQueen, H A +4 more
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CpG islands – ‘A rough guide’ [PDF]
FEBS Letters, 2009 Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associate with the majority of annotated gene promoters. Many studies, however, have identified examples of CGI methylation in malignant cells, leading to improper gene silencing.
Robert S. Illingworth, Adrian Bird
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CpG islands and the regulation of transcription [PDF]
Genes & Development, 2011 Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most, perhaps all, CGIs are sites of transcription initiation, including thousands that are remote from currently annotated promoters.
Deaton, Aimee M., Bird, Adrian
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Preservation of methylated CpG dinucleotides in human CpG islands [PDF]
Biology Direct, 2016 CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Vsevolod J. Makeev +3 more
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Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet +11 more
wiley +1 more source
DNA methylation and chromatin structure: The puzzling CpG islands [PDF]
, 2005 DNA methylation is the epigenetic modification,which introduces 5mC as fifth base onto DNA. As for the distribution of 5rnCs, it is well known that they distribute themselves in a non-random fashion in genomic DNA so that methylation pattern is ...
CAIAFA, Paola, ZAMPIERI, Michele
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Primate CpG Islands Are Maintained by Heterogeneous Evolutionary Regimes Involving Minimal Selection [PDF]
, 2011 SummaryMammalian CpG islands are key epigenomic elements that were first characterized experimentally as genomic fractions with low levels of DNA methylation. Currently, CpG islands are defined based on their genomic sequences alone.
Cohen, Netta Mendelson +2 more
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Histone methylation marks play important roles in predicting the methylation status of CpG islands [PDF]
, 2008 The methylation status of CpG islands is highly correlated with gene expression. Current methods for computational prediction of DNA methylation only utilize DNA sequence features.
Fan, S., Zhang, M. Q., Zhang, X.
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Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs [PDF]
, 2016 BACKGROUND: DNA methylation levels will be important for detection of epigenetic effects. However, there are few reports showing sex-related differences in the sensitivity to DNA methylation.
Chika Honda +14 more
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Teeing Up Transcription on CpG Islands [PDF]
Journal of End-to-End-testing, 2009 Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al ...
Harinder Singh, Harinder Singh
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