Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications [PDF]
eLifeThe majority of vertebrate promoters have a distinct DNA composition, known as a CpG island. Cytosine methylation in promoter CpG islands is associated with a substantial reduction of transcription initiation.
Rasa Giniūnaitė +4 more
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Keep Fingers on the CpG Islands [PDF]
EpigenomesThe post-genomic era has ushered in the extensive application of epigenetic editing tools, allowing for precise alterations of gene expression. The use of reprogrammable editors that carry transcriptional corepressors has significant potential for long ...
Xing Zhang +2 more
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The Role of H3K4 Trimethylation in CpG Islands Hypermethylation in Cancer [PDF]
Biomolecules, 2021 CpG methylation in transposons, exons, introns and intergenic regions is important for long-term silencing, silencing of parasitic sequences and alternative promoters, regulating imprinted gene expression and determining X chromosome inactivation ...
Giuseppe Zardo
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De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands [PDF]
Nature Communications, 2021 Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of ...
Roza H. Ali Masalmeh +13 more
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Modeling methylation dynamics with simultaneous changes in CpG islands [PDF]
BMC Bioinformatics, 2020 Background In vertebrate genomes, CpG sites can be clustered into CpG islands, and the amount of methylation in a CpG island can change due to gene regulation processes.
Konrad Grosser, Dirk Metzler
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Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands. [PDF]
PLoS ONE, 2012 DNA methylation of CpG islands plays a crucial role in the regulation of gene expression. More than half of all human promoters contain CpG islands with a tissue-specific methylation pattern in differentiated cells.
Clemens Wrzodek +6 more
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QUFIND: tool for comparative prediction and mining of G4 quadruplexes overlapping with CpG islands [PDF]
Frontiers in Genetics, 2023 G-quadruplexes (G4s) are secondary structures in DNA that have been shown to be involved in gene regulation. They play a vital role in the cellular processes and several pathogens including bacteria, fungi, and viruses have also been shown to possess G4s
Baljeet Kaur +3 more
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A Hybrid Approach for CpG Island Detection in the Human Genome. [PDF]
PLoS ONE, 2016 BACKGROUND:CpG islands have been demonstrated to influence local chromatin structures and simplify the regulation of gene activity. However, the accurate and rapid determination of CpG islands for whole DNA sequences remains experimentally and ...
Cheng-Hong Yang +3 more
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BMC Bioinformatics, 2006 Background Despite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defining CpG islands (CGIs), since all current approaches rely on a large ...
Carpena Pedro +5 more
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CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. [PDF]
PLoS Genetics, 2006 CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer.
Christoph Bock +5 more
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