Modeling methylation dynamics with simultaneous changes in CpG islands [PDF]
BMC Bioinformatics, 2020 Background In vertebrate genomes, CpG sites can be clustered into CpG islands, and the amount of methylation in a CpG island can change due to gene regulation processes.
Konrad Grosser, Dirk Metzler
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CpG islands – ‘A rough guide’ [PDF]
FEBS Letters, 2009 Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associate with the majority of annotated gene promoters. Many studies, however, have identified examples of CGI methylation in malignant cells, leading to improper gene silencing.
Robert S. Illingworth, A. Bird
semanticscholar +4 more sources
Particle swarm optimization with reinforcement learning for the prediction of CpG islands in the human genome. [PDF]
PLoS ONE, 2011 BACKGROUND: Regions with abundant GC nucleotides, a high CpG number, and a length greater than 200 bp in a genome are often referred to as CpG islands. These islands are usually located in the 5' end of genes.
Li-Yeh Chuang +3 more
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Bidding the CpG island goodbye [PDF]
eLife, 2013 Experiments on seven vertebrates suggest that identifying the locations of islands of non-methylated DNA provides more insights into evolutionarily-conserved epigenetic regulatory elements than studies of CpG islands.
John M Greally
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CpG Island Methylation in Colorectal Adenomas [PDF]
The American Journal of Pathology, 2001 Methylation of cytosines in CpG islands silences gene expression. CpG island methylator phenotype (CIMP) in colorectal cancers is characterized by abnormal methylation of multiple CpG islands including those in several tumor suppressor genes such as p16, hMLH1, and THBS1. CpG island methylation has not been well characterized in adenomas.
Asif Rashid +4 more
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Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands. [PDF]
PLoS ONE, 2012 DNA methylation of CpG islands plays a crucial role in the regulation of gene expression. More than half of all human promoters contain CpG islands with a tissue-specific methylation pattern in differentiated cells.
Clemens Wrzodek +6 more
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Inhibitory effect of alpinetin on IL‐6 expression by promoting cytosine methylation in CpG islands in the IL‐6 promoter region [PDF]
Molecular Genetics & Genomic Medicine, 2020 Background Alpinetin is a flavonoid which exerts antibacterial and anti‐inflammatory functions. In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin‐6 (IL‐6)
Ke Hu +8 more
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Prediction of CpG-island function: CpG clustering vs. sliding-window methods [PDF]
BMC Genomics, 2010 Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ratio and length thresholds as
Luque-Escamilla Pedro L +5 more
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BMC Cancer, 2012 Background Many miR genes are located within or around CpG islands. It is unclear whether methylation of these CpG islands represses miR transcription regularly. The aims of this study are to characterize gastric carcinoma (GC)-related methylation of miR
Du Yantao +6 more
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Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands. [PDF]
Nat Genet, 2021 Weinberg DN +11 more
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