Results 21 to 30 of about 71,046 (242)
Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]
, 2015 We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi +6 more
core +1 more source
Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias [PDF]
, 2014 We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investigate
Borssén, Magnus +10 more
core +1 more source
PLoS ONE, 2007 BackgroundMajority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, but most CpG islands are resistant to such epigenetic modification. Understanding about mechanisms that may lead to the methylation resistance of CpG islands is
Shicai Fan +3 more
doaj +1 more source
Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands. [PDF]
PLoS ONE, 2012 DNA methylation of CpG islands plays a crucial role in the regulation of gene expression. More than half of all human promoters contain CpG islands with a tissue-specific methylation pattern in differentiated cells.
Clemens Wrzodek +6 more
doaj +1 more source
Prediction of CpG-island function: CpG clustering vs. sliding-window methods
BMC Genomics, 2010 Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ratio and length thresholds as
Luque-Escamilla Pedro L +5 more
doaj +1 more source
Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]
, 2018 In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia +9 more
core +1 more source
Evolution of CpG-islands by means of tandem duplications
Вавиловский журнал генетики и селекции, 2017 CG-rich islands (CpG-islands, or CGI) are important functional elements in a genome of vertebrates. In particular, they: a) initiate transcription as promoters in most (> 50 %) genes of vertebrates, in some cases bi-directional, due to self-complement
V. N. Babenko +4 more
doaj +1 more source
Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. [PDF]
PLoS ONE, 2012 BACKGROUND: The exact relationship between nucleosome positioning and methylation of CpG islands in human pathogenesis is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we characterized the nucleosome position within the p16 CpG island ...
Zhe-Ming Lu +9 more
doaj +1 more source
CpG islands – ‘A rough guide’ [PDF]
FEBS Letters, 2009 Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associate with the majority of annotated gene promoters. Many studies, however, have identified examples of CGI methylation in malignant cells, leading to improper gene silencing.
Illingworth, Robert S., Bird, Adrian P.
openaire +2 more sources
Molecular Genetics & Genomic Medicine, 2020 Background Alpinetin is a flavonoid which exerts antibacterial and anti‐inflammatory functions. In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin‐6 (IL‐6)
Ke Hu +8 more
doaj +1 more source