Results 21 to 30 of about 869,007 (330)
Orphan CpG islands as alternative promoters. [PDF]
Transcription, 2018 CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on aberrant activation of oncogenes in cancer phenotypes.
Sarda S, Hannenhalli S.
europepmc +4 more sources
New Twists on the Epigenetics of CpG Islands [PDF]
Genome Research, 2002 Rolf Ohlsson, Chandrasekhar Kanduri
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CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. [PDF]
PLoS Genetics, 2006 CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer.
Christoph Bock +5 more
doaj +2 more sources
Genome Research, 1997 We describe an analysis of the CpG islands (CGIs) of the pig. We have used both database survey and a porcine genomic library that is enriched for CGIs. Approximately half of 41 pig genomic database sequences had CGIs with an average G + C content of 65.3%, an average CpG observed/expected frequency of 0.85, and an average size of 978 bp.
McQueen, H A +4 more
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Tissue mosaicism, FMR1 expression and intellectual functioning in males with fragile X syndrome
American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 357-369, February 2023., 2023 Abstract Fragile X syndrome (FXS) is caused by hypermethylation of the FMR1 promoter due to the full mutation expansion (full mutation [FM]: CGG ≥ 200 repeats) and silencing of FMR1. Assessment of mosaicism for active‐unmethylated alleles has prognostic utility.
Emma K. Baker +17 more
wiley +1 more source
CpG islands undermethylation in human genomic regions under selective pressure. [PDF]
PLoS ONE, 2011 DNA methylation at CpG islands (CGIs) is one of the most intensively studied epigenetic mechanisms. It is fundamental for cellular differentiation and control of transcriptional potential.
Sergio Cocozza +3 more
doaj +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Protein cysteine residues can be oxidized by nitric oxide (NO) to form protein S‐nitrosothiols (SNOs) in a process called S‐nitrosylation. S‐nitrosoglutathione reductase (GSNOR) is a highly specific denitrase for GSNO; it controls the intracellular levels of GSNO and protein SNOs and protects the body from nitrosative stress.
Yu‐Xin Zhang +9 more
wiley +1 more source
Preservation of methylated CpG dinucleotides in human CpG islands [PDF]
Biology Direct, 2016 CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Vsevolod J. Makeev +3 more
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Cancer Medicine, Volume 11, Issue 24, Page 5066-5078, December 2022., 2022 SSA/Ps showed characteristic gene expression with a strong resemblance to microsatellite instability‐high colorectal cancer. And the downregulation of CDX2 expression is an essential molecular mechanism involved in the initial stage of SSA/P tumorigenesis.
Daisuke Ohki +12 more
wiley +1 more source
A Hybrid Approach for CpG Island Detection in the Human Genome. [PDF]
PLoS ONE, 2016 BACKGROUND:CpG islands have been demonstrated to influence local chromatin structures and simplify the regulation of gene activity. However, the accurate and rapid determination of CpG islands for whole DNA sequences remains experimentally and ...
Cheng-Hong Yang +3 more
doaj +1 more source