Results 21 to 30 of about 44,983 (183)
CpG islands – ‘A rough guide’ [PDF]
FEBS Letters, 2009 Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associate with the majority of annotated gene promoters. Many studies, however, have identified examples of CGI methylation in malignant cells, leading to improper gene silencing.
Illingworth, Robert S., Bird, Adrian P.
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Molecular Genetics & Genomic Medicine, 2020 Background Alpinetin is a flavonoid which exerts antibacterial and anti‐inflammatory functions. In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin‐6 (IL‐6)
Ke Hu +8 more
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Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. [PDF]
PLoS ONE, 2012 BACKGROUND: The exact relationship between nucleosome positioning and methylation of CpG islands in human pathogenesis is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we characterized the nucleosome position within the p16 CpG island ...
Zhe-Ming Lu +9 more
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GaussianCpG: a Gaussian model for detection of CpG island in human genome sequences
BMC Genomics, 2017 Background As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome ...
Ning Yu +3 more
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Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation. [PDF]
PLoS ONE, 2014 DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples.
Wengang Song +6 more
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Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping [PDF]
Journal of Clinical Laboratory Analysis, 2015 BackgroundDetermination of the differential DNA methylation patterns of methylenetetrahydrofolate reductase (MTHFR) that are associated with differential MTHFR activity is important to understand the pathogenesis of ischemic stroke. However, to date, no data are available on the differential DNA methylation profiles of Kelantanese Malays. Therefore, we
Loo, Keat Wei +6 more
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An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits
Frontiers in Genetics, 2019 Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research.
Xiao Wang, Haja N. Kadarmideen
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BMC Medical Genomics, 2008 Background Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.
DeGeest Koen +5 more
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Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. [PDF]
PLoS Genetics, 2007 The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated CpG ...
Lanlan Shen +9 more
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Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. [PDF]
PLoS Genetics, 2012 We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands.
Altuna Akalin +21 more
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