Results 21 to 30 of about 28,422 (165)
Bidding the CpG island goodbye [PDF]
eLife, 2013 Experiments on seven vertebrates suggest that identifying the locations of islands of non-methylated DNA provides more insights into evolutionarily-conserved epigenetic regulatory elements than studies of CpG islands.
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Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]
, 2007 Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
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Methylation of CpG island is not a ubiquitous mechanism for the loss of oestrogen receptor in breast cancer cells. [PDF]
, 1998 Methylation has been shown to play an important role in the down-regulation of oestrogen receptors (ER) in breast cancer cells. One critical question that remains unclear is whether methylation can account for the loss of ER expression in cells derived ...
Chen, Z, Jordan, VC, Ko, A, Yang, J
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CpG Islands: A Historical Perspective
, 2018 The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium.
Antequera, Francisco, Bird, Adrian
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CpG Islands Detector: a Window-based CpG Island Search Tool [PDF]
Genomics & Informatics, 2010 Abstract CpG is the pair of nucleotides C and G, appearing suc-cessively, in this order, along one DNA strand. It is known that due to biochemical considerations CpG is relatively rare in most DNA sequences. However, in par-ticular subsequences, which are a few hundred to a few thousand nucleotides long, the couple CpG is more frequent.
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Predicting aberrant CpG island methylation [PDF]
Proceedings of the National Academy of Sciences, 2003 Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of ...
Christoph Plass +5 more
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DNA methylation and DNA methyltransferases [PDF]
, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H +3 more
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CpG island mapping by epigenome prediction
PLoS Computational Biology, 2005 CpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by simple DNA sequence criteria, which allowed for genome-wide annotation of CpG islands in the absence of large-scale epigenetic datasets. Although widely used,
Bock, C. +3 more
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CpG Island Hypermethylation in Human Astrocytomas [PDF]
Cancer Research, 2010 Abstract Astrocytomas are common and lethal human brain tumors. We have analyzed the methylation status of over 28,000 CpG islands and 18,000 promoters in normal human brain and in astrocytomas of various grades using the methylated CpG island recovery assay.
Xueyan Zhong +6 more
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CpG Islands Shape the Epigenome Landscape
Journal of Molecular Biology, 2021 Epigenetic modifications and nucleosome positioning play an important role in modulating gene expression. However, how the patterns of epigenetic modifications and nucleosome positioning are established around promoters is not well understood.
Papin, Christophe +12 more
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