Results 41 to 50 of about 869,007 (330)
Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line. [PDF]
PLoS ONE, 2010 Methylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ) in human oral cancer cell line resulted in accumulation of
Daisuke Yamamoto +7 more
doaj +1 more source
Factors to preserve CpG-rich sequences in methylated CpG islands [PDF]
BMC Genomics, 2015 Mammalian CpG islands (CGIs) normally escape DNA methylation in all adult tissues and developmental stages. However, in our previous study we unexpectedly identified many methylated CGIs in human peripheral blood leukocytes. Methylated CpG dinucleotides convert to TpG dinucleotides through deaminization of their cytosine bases more frequently than ...
Hiroki Miyahara +3 more
openaire +2 more sources
Higher order methylation features for clustering and prediction in epigenomic studies [PDF]
Bioinformatics (2016) 32 (17): i405-i412, 2016 Motivation: DNA methylation is an intensely studied epigenetic mark, yet its functional role is incompletely understood. Attempts to quantitatively associate average DNA methylation to gene expression yield poor correlations outside of the well-understood methylation-switch at CpG islands.
arxiv +1 more source
Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 2017 The Polycomb repressive complex 2 (PRC2) mainly mediates transcriptional repression and has essential roles in various biological processes including the maintenance of cell identity and proper differentiation. Polycomb-like (PCL) proteins, such as PHF1,
Haojie Li +11 more
semanticscholar +1 more source
Evolution of CpG-islands by means of tandem duplications
Вавиловский журнал генетики и селекции, 2017 CG-rich islands (CpG-islands, or CGI) are important functional elements in a genome of vertebrates. In particular, they: a) initiate transcription as promoters in most (> 50 %) genes of vertebrates, in some cases bi-directional, due to self-complement
V. N. Babenko +4 more
doaj +1 more source
Nature Communications, 2018 Epigenetic modifications such as aberrant DNA methylation reshape the gene expression repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) mouse model (Alb-R26Met) to explore the impact of DNA methylation on ...
M. Arechederra +8 more
semanticscholar +1 more source
Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation. [PDF]
PLoS ONE, 2014 DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples.
Wengang Song +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance The human genome contains ∼30,000 CpG islands (CGIs), long stretches (0.5–2 kb) of DNA with unusually elevated levels of CpG dinucleotides. Many occur at genes' promoters, and their DNA nearly always remains unmethylated.
D. Jeziorska +15 more
semanticscholar +1 more source
GaussianCpG: a Gaussian model for detection of CpG island in human genome sequences
BMC Genomics, 2017 Background As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome ...
Ning Yu +3 more
doaj +1 more source
Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
Nucleic Acids Research, 2016 DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often associated with gene promoters and play central roles in gene regulation.
H. K. Long +4 more
semanticscholar +1 more source