Results 41 to 50 of about 71,046 (242)
Predicting aberrant CpG island methylation [PDF]
Proceedings of the National Academy of Sciences, 2003 Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of ...
F A, Feltus +4 more
openaire +2 more sources
Solution structure of human MBD1 CXXC1 [PDF]
, 2015 No abstract ...
Smith, Brian O., Thomson, Ross
core +2 more sources
Links between DNA methylation and nucleosome occupancy in the human genome
Epigenetics & Chromatin, 2017 Background DNA methylation is an epigenetic modification that is enriched in heterochromatin but depleted at active promoters and enhancers. However, the debate on whether or not DNA methylation is a reliable indicator of high nucleosome occupancy has ...
Clayton K. Collings, John N. Anderson
doaj +1 more source
Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis [PDF]
, 2015 Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is ...
Agnoli, C +25 more
core +5 more sources
Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation. [PDF]
PLoS Genetics, 2006 DNA methylation is a hallmark of transcriptional silencing, yet transcription has been reported at the centromere. To address this apparent paradox, we employed a fully sequence-defined ectopic human centromere (or neocentromere) to investigate the ...
Nicholas C Wong +7 more
doaj +2 more sources
BMC Cancer, 2012 Background Many miR genes are located within or around CpG islands. It is unclear whether methylation of these CpG islands represses miR transcription regularly. The aims of this study are to characterize gastric carcinoma (GC)-related methylation of miR
Du Yantao +6 more
doaj +1 more source
Global methylation patterns in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2012 BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is characterized by profound changes in the lung phenotype including excessive extracellular matrix deposition, myofibroblast foci, alveolar epithelial cell hyperplasia and extensive remodeling.
Einat I Rabinovich +7 more
doaj +1 more source
Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus [PDF]
, 1996 The methyl-CpG binding domain (MBD) proteins are key molecules in the interpretation of DNA methylation signals leading to gene silencing. We investigated their binding specificity at the constitutively methylated region of a CpG island containing the ...
Auriol, Emilie +3 more
core +2 more sources
Preservation of methylated CpG dinucleotides in human CpG islands [PDF]
Biology Direct, 2016 CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Panchin, Alexander Y. +2 more
openaire +2 more sources
Identification of CpG islands using a bank of IIR lowpass filters [PDF]
, 2004 It has been known that biological sequences such as the DNA sequence display different kinds of patterns depending on their biological functions. This statistical difference can be exploited for identifying the region of interest, such as the protein ...
Vaidyanathan, P. P., Yoon, Byung-Jun
core