Results 41 to 50 of about 44,983 (183)
Intra-Monozygotic Twin Pair Discordance and Longitudinal Variation of Whole-Genome Scale DNA Methylation in Adults. [PDF]
PLoS ONE, 2015 Monozygotic twins share identical genomic DNA and are indistinguishable using conventional genetic markers. Increasing evidence indicates that monozygotic twins are epigenetically distinct, suggesting that a comparison between DNA methylation patterns ...
Na Zhang +6 more
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CpG Islands Detector: a Window-based CpG Island Search Tool [PDF]
Genomics & Informatics, 2010 Abstract CpG is the pair of nucleotides C and G, appearing suc-cessively, in this order, along one DNA strand. It is known that due to biochemical considerations CpG is relatively rare in most DNA sequences. However, in par-ticular subsequences, which are a few hundred to a few thousand nucleotides long, the couple CpG is more frequent.
openaire +1 more source
Methylated-CpG Island Recovery Assay [PDF]
, 2011 Alterations in DNA methylation patterns are implicated in playing a major role in the development of cancer, thus highlighting the need to continually develop new technologies to analyze epigenetic marks. Methylated-CpG Island Recovery Assay (MIRA), based on the high affinity of the MBD2b/MDB3L1 complex for double-stranded methylated DNA, allows for ...
Natalie, Mitchell +2 more
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Orphan CpG islands as alternative promoters. [PDF]
Transcription, 2018 CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on aberrant activation of oncogenes in cancer phenotypes.
Sarda S, Hannenhalli S.
europepmc +3 more sources
CpG Island Hypermethylation in Human Astrocytomas [PDF]
Cancer Research, 2010 Abstract Astrocytomas are common and lethal human brain tumors. We have analyzed the methylation status of over 28,000 CpG islands and 18,000 promoters in normal human brain and in astrocytomas of various grades using the methylated CpG island recovery assay.
Xiwei, Wu +6 more
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Spreadsheet-Based Program for the Analysis of DNA Methylation
BioTechniques, 2001 Methylation of DNA in CpG dense regions of gene promoters (CpG islands) is important for transcriptional inactivation of selective genes in normal and neoplastic cells.
Ramaswamy Anbazhagan +3 more
doaj +1 more source
CpGPAP: CpG island predictor analysis platform [PDF]
BMC Genetics, 2012 Abstract Background Genomic islands play an important role in medical, methylation and biological studies. To explore the region, we propose a CpG islands prediction analysis platform for genome sequence exploration (CpGPAP).
Chuang Li-Yeh +3 more
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BMC Genomics, 2011 Background Due to its overarching role in genome function, sequence-dependent DNA curvature continues to attract great attention. The DNA double helix is not a rigid cylinder, but presents both curvature and flexibility in different regions, depending on
Jáuregui Ruy +2 more
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CpG Island Methylation in Colorectal Adenomas [PDF]
The American Journal of Pathology, 2001 Methylation of cytosines in CpG islands silences gene expression. CpG island methylator phenotype (CIMP) in colorectal cancers is characterized by abnormal methylation of multiple CpG islands including those in several tumor suppressor genes such as p16, hMLH1, and THBS1. CpG island methylation has not been well characterized in adenomas.
A, Rashid +4 more
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Factors to preserve CpG-rich sequences in methylated CpG islands [PDF]
BMC Genomics, 2015 Mammalian CpG islands (CGIs) normally escape DNA methylation in all adult tissues and developmental stages. However, in our previous study we unexpectedly identified many methylated CGIs in human peripheral blood leukocytes. Methylated CpG dinucleotides convert to TpG dinucleotides through deaminization of their cytosine bases more frequently than ...
Miyahara, Hiroki +3 more
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