Results 51 to 60 of about 44,983 (183)

Diversity of core promoter elements comprising human bidirectional promoters

BMC Genomics, 2008
Background Bidirectional promoters lie between adjacent genes, which are transcribed from opposite strands of DNA. The functional mechanisms underlying the activation of bidirectional promoters are currently uncharacterised.
Elnitski Laura L, Yang Mary
doaj   +1 more source

In silico enhanced restriction enzyme based methylation analysis of the human glioblastoma genome using Agilent 244K CpG Island microarrays

Frontiers in Neuroscience, 2010
Genome wide methylation profiling of gliomas is likely to provide important clues to improving treatment outcomes. Restriction enzyme based approaches have been widely utilized for methylation profiling of cancer genomes and will continue to have ...
Anh Tran, Anh Tran, Cameron Escovedo, Cameron Escovedo, Justine Migdall-Wilson, Arthur Chou, Weidong Chen, Weidong Chen, Timothy Cloughesy, Timothy Cloughesy, Stanley Nelson, Albert Lai, Albert Lai   +12 more
doaj   +1 more source

Bidding the CpG island goodbye

eLife, 2013
Experiments on seven vertebrates suggest that identifying the locations of islands of non-methylated DNA provides more insights into evolutionarily-conserved epigenetic regulatory elements than studies of CpG islands.
John M Greally
doaj   +1 more source

CpG islands identification in DNA sequences using modified P-spectrum based algorithm

, 2021
Pardeep Garg, Sunil Sharma
openalex   +1 more source

Teeing Up Transcription on CpG Islands [PDF]

Journal of End-to-End-testing, 2009
Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al ...
openaire   +2 more sources

Identification of DNA-Methylated CpG Islands Associated With Gene Silencing in the Adult Body Tissues of the Ogye Chicken Using RNA-Seq and Reduced Representation Bisulfite Sequencing

Frontiers in Genetics, 2019
DNA methylation is an epigenetic mark that plays an essential role in regulating gene expression. CpG islands are DNA methylations regions in promoters known to regulate gene expression through transcriptional silencing of the corresponding gene.
Won-Jun Lim, Won-Jun Lim, Kyoung Hyoun Kim, Kyoung Hyoun Kim, Jae-Yoon Kim, Jae-Yoon Kim, Seongmun Jeong, Namshin Kim, Namshin Kim   +8 more
doaj   +1 more source

CpG Islands: A Historical Perspective

, 2018
The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium.
Antequera, Francisco, Bird, Adrian
openaire   +3 more sources

Dissecting the Kaiso binding profile in clear renal cancer cells

Epigenetics & Chromatin
Background There has been a notable increase in interest in the transcriptional regulator Kaiso, which has been linked to the regulation of clonal hematopoiesis, myelodysplastic syndrome, and tumorigenesis.
Alexey Starshin, Pavel Abramov, Yaroslava Lobanova, Fedor Sharko, Galina Filonova, Dmitry Kaluzhny, Daria Kaplun, Igor Deyev, Alexander Mazur, Egor Prokhortchou, Svetlana Zhenilo   +10 more
doaj   +1 more source

Extensive sequence-influenced DNA methylation polymorphism in the human genome

Epigenetics & Chromatin, 2010
Background Epigenetic polymorphisms are a potential source of human diversity, but their frequency and relationship to genetic polymorphisms are unclear.
Hellman Asaf, Chess Andrew
doaj   +1 more source

CpG Islands and Double-Minute Chromosomes

Genomics, 1998
Double-minute chromosomes (DMs) amplify oncogenes in human tumors. The organization of genomic DNA in four independently isolated DMs amplifying the DHFR (dihydrofolate reductase) gene has been compared by mapping locations of CpG islands. When cleaved with methylation-sensitive rare-cutting restriction endonucleases, three hypomethylated GC-rich DNA ...
R, Rizwana, P J, Hahn
openaire   +2 more sources