Results 61 to 70 of about 71,046 (242)

Genetic Factors Contributing to the Susceptibility of Development of Prion Diseases [PDF]

, 2017
This paper won an honorable mention writing flag award in the research category. Claire Culbertson, writing for Katherine Bruner’s BIO 325L class, “Lab Experience in Genetics”.Bruner, KatherineUndergraduate ...
Culbertson, Claire
core   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

The Echinococcus canadensis (G7) genome: A key knowledge of parasitic platyhelminth human diseases [PDF]

, 2017
Background: The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents of echinococcosis. Echinococcosis is a worldwide chronic zoonosis affecting humans as well as domestic and wild mammals, which ...
A Bankevich, A Gurevich, A Lomsadze, A Lomsadze, Adolfo Fox, AM Bolger, Anna C. M. Salim, B Hendrich, B Langmead, C Bermudez-Santana, C Hahn, C Holt, C Jiang, C Trapnell, CA Alvarez Rojas, CCM Budke, D Kim, D Takai, DP McManus, DR Zerbino, E Elkayam, E Keibler, E Quevillon, F Jeanmougin, F Kiefer, F Mohn, Federico Camicia, Flávio M. Gomes Araújo, G Abrusán, G Parra, GSC Slater, Guilherme Oliveira, H Li, H Zheng, I Korf, IJ Tsai, IJ Tsai, J Eckert, JK Nono, JM Bart, JP Hewitson, Juliana Assis, K Arnold, K Matsuo, K Thivierge, K Wasik, KJ Fryxell, KK Geyer, KK Geyer, L Han, L Han, L Kamenetzky, L Kamenetzky, L Kamenetzky, L Li, LA Kelley, Laura Kamenetzky, LD Moore, Lucas L. Maldonado, M Ashburner, M Biasini, M Cucher, M Cucher, M Krzywinski, M Marín, M Nakao, M Nakao, M Nakao, M Nakao, M Nakao, M Rosenzvit, M Sajid, M Stanke, MA Cucher, Mara Rosenzvit, Marcela Cucher, MC Rosenzvit, MW Robinson, N Guex, N Macchiaroli, N Schürmann, Natalia Macchiaroli, ND Young, O Bogdanović, P Carninci, P Cingolani, P Danecek, PM Muzulin, PM Schantz, PS Craig, R Luo, R Schneider, RD Finn, RJ Klose, S Assefa, S Maillard, S Saxonov, S Yi, SF Altschul, SM Sadjjadi, TD Otto, TD Otto, TM Lowe, U Koziol, U Saarma, W Pan, Y Moriya, Y Safonova, YA Medvedeva, Z Zhao   +109 more
core   +8 more sources

Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling

Advanced Science, EarlyView.
Phase separation is emerging as a multiscale organizing principle of genome folding across scales, from nucleosomes and transcriptional condensates to chromatin domains and nuclear compartments. By integrating physics‐based simulations with data‐driven inference, computational modeling now links molecular interactions to nuclear architecture and points
Jiahu Tang, Cibo Feng, Haibin Su, Xiakun Chu   +3 more
wiley   +1 more source

Intra-Monozygotic Twin Pair Discordance and Longitudinal Variation of Whole-Genome Scale DNA Methylation in Adults. [PDF]

PLoS ONE, 2015
Monozygotic twins share identical genomic DNA and are indistinguishable using conventional genetic markers. Increasing evidence indicates that monozygotic twins are epigenetically distinct, suggesting that a comparison between DNA methylation patterns ...
Na Zhang, Shumin Zhao, Su-Hua Zhang, Jinzhong Chen, Daru Lu, Min Shen, Chengtao Li   +6 more
doaj   +1 more source

A Toll for lupus [PDF]

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders HJ, H-J Anders, Stacey KJ
core   +1 more source

CpG Islands Shape the Epigenome Landscape

Journal of Molecular Biology, 2021
Epigenetic modifications and nucleosome positioning play an important role in modulating gene expression. However, how the patterns of epigenetic modifications and nucleosome positioning are established around promoters is not well understood.
Papin, Christophe, Le Gras, Stéphanie, Ibrahim, Abdulkhaleg, Salem, Hatem, Karimi, Mohammad Mahdi, Stoll, Isabelle, Ugrinova, Iva, Schröder, Maria, Fontaine-Pelletier, Emeline, Omran, Ziad, Bronner, Christian, Dimitrov, Stefan, Hamiche, Ali   +12 more
openaire   +3 more sources

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

Exploring genome wide bisulfite sequencing for DNA methylation analysis in livestock: a technical assessment [PDF]

, 2014
peer-reviewedRecent advances made in “omics” technologies are contributing to a revolution in livestock selection and breeding practices. Epigenetic mechanisms, including DNA methylation are important determinants for the control of gene expression in ...
Couldrey, Christine, Doherty, Rachael
core   +2 more sources

CpG Islands Detector: a Window-based CpG Island Search Tool [PDF]

Genomics & Informatics, 2010
Abstract CpG is the pair of nucleotides C and G, appearing suc-cessively, in this order, along one DNA strand. It is known that due to biochemical considerations CpG is relatively rare in most DNA sequences. However, in par-ticular subsequences, which are a few hundred to a few thousand nucleotides long, the couple CpG is more frequent.
openaire   +1 more source