Results 61 to 70 of about 28,422 (165)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Solution structure of human MBD1 CXXC1 [PDF]

, 2015
No abstract ...
Smith, Brian O., Thomson, Ross
core   +2 more sources

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Comparative (computational) analysis of the DNA methylation status of trinucleotide repeat expansion diseases [PDF]

, 2013
Copyright © 2013 Mohammadmersad Ghorbani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is ...
Ghorbani, M, Payne, A, Pook, MA, Taylor, SJE   +3 more
core   +4 more sources

An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21

, 2004
An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb.
Aaltonen, Aaltonen, Arques, Baldi, Bernardi, Bernardi, Borodovsky, Burge, Clay, Clay, Clay, Dirk Holste, Fickett, Fukushima, Golfier, Grosse, Guigo, Hattori, Herzel, Holste, Konopka, Larsen, Li, Li, Li, Macaya, McKusick, Nagamine, Nekrutenko, Oliver, Oliver, Pavlícek, Pizzi, Saccone, Shiba, Shulman, Smit, Staden, Tiwari, Tomita, Trifonov, Trifonov, Wentian Li, Widom, Zhurkin   +44 more
core   +2 more sources

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]

, 2010
Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J, Daley, George Q, Doi, Akiko, Ehrlich, Lauren IR, Feinberg, Andrew P, Ho, Lena, Inlay, Matthew A, Irizarry, Rafael A, Ji, Hong, Karsunky, Holger, Kim, Kitai, Lee, Hwajin, Lindau, Paul, Murakami, Peter, Rossi, Derrick J, Seita, Jun, Serwold, Thomas, Weissman, Irving L   +17 more
core   +2 more sources

Prediction of CpG-island function: CpG clustering vs. sliding-window methods [PDF]

BMC Genomics, 2010
Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ratio and length thresholds as main parameters.
Michael Hackenberg, José L. Oliver, Pedro L. Luque-Escamilla, Guillermo Barturen, Christopher Previti, Pedro Carpena, Pedro Carpena   +6 more
openaire   +6 more sources

A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research

International Journal of Cancer, EarlyView.
Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez, Isabel Sierra, Jop Kind   +2 more
wiley   +1 more source

Parametric Inference for Biological Sequence Analysis [PDF]

, 2004
One of the major successes in computational biology has been the unification, using the graphical model formalism, of a multitude of algorithms for annotating and comparing biological sequences.
B. Sturmfels, Gardiner-Garden, Gusfield, L. Pachter, Lander, Waterman   +5 more
core   +4 more sources

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source