Results 61 to 70 of about 869,007 (330)
Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells
Science, 2017 Stable epigenetic modifications can be introduced into stem cells via precise and targeted manipulation of DNA methylation. Inducing DNA methylation where it wasn't The specific order of DNA's purines and pyrimidines encodes proteins, but chemically ...
Yuta Takahashi +12 more
semanticscholar +1 more source
Molecular Ecology Resources, EarlyView., 2023 Abstract A high‐quality reference genome can be a valuable resource for threatened species by providing a foundation to assess their evolutionary potential to adapt to future pressures such as environmental change. We assembled the genome of a female hihi (Notiomysits cincta), a threatened passerine bird endemic to Aotearoa New Zealand.
Sarah Bailey +7 more
wiley +1 more source
Global methylation patterns in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2012 BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is characterized by profound changes in the lung phenotype including excessive extracellular matrix deposition, myofibroblast foci, alveolar epithelial cell hyperplasia and extensive remodeling.
Einat I Rabinovich +7 more
doaj +1 more source
Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands
EMBO Journal, 2017 DNA methylation is a prevalent epigenetic modification involved in transcriptional regulation and essential for mammalian development. While the genome‐wide distribution of this mark has been studied to great detail, the mechanisms responsible for its ...
M. Manzo +5 more
semanticscholar +1 more source
CpG Islands: A Historical Perspective
, 2018 The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium.
Antequera, Francisco, Bird, Adrian
openaire +4 more sources
CpG Islands Detector: a Window-based CpG Island Search Tool [PDF]
Genomics & Informatics, 2010 Abstract CpG is the pair of nucleotides C and G, appearing suc-cessively, in this order, along one DNA strand. It is known that due to biochemical considerations CpG is relatively rare in most DNA sequences. However, in par-ticular subsequences, which are a few hundred to a few thousand nucleotides long, the couple CpG is more frequent.
openaire +2 more sources
Links between DNA methylation and nucleosome occupancy in the human genome
Epigenetics & Chromatin, 2017 Background DNA methylation is an epigenetic modification that is enriched in heterochromatin but depleted at active promoters and enhancers. However, the debate on whether or not DNA methylation is a reliable indicator of high nucleosome occupancy has ...
Clayton K. Collings, John N. Anderson
doaj +1 more source
Decision Knowledge Graphs: Construction of and Usage in Question Answering for Clinical Practice Guidelines [PDF]
arXiv, 2023 In the medical domain, several disease treatment procedures have been documented properly as a set of instructions known as Clinical Practice Guidelines (CPGs). CPGs have been developed over the years on the basis of past treatments, and are updated frequently.
arxiv
Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive [PDF]
Nucleic Acids Research, Oxford University Press, 2016, 44 (2),
pp.621 - 635, 2018 Parental allele-specific expression of imprinted genes is mediated by imprinting control regions (ICRs) that are constitutively marked by DNA methylation imprints on the maternal or paternal allele. Mono-allelic DNA methylation is strictly required for the process of imprinting and has to be faithfully maintained during the entire lifespan.
arxiv +1 more source
Cell Research, 2015 Despite advances in DNA methylome analyses of cells and tissues, current techniques for genome-scale profiling of DNA methylation in circulating cell-free DNA (ccfDNA) remain limited. Here we describe a methylated CpG tandems amplification and sequencing
Lu Wen +17 more
semanticscholar +1 more source