Results 101 to 110 of about 526,765 (304)
The dendritic cell niche in chronic obstructive pulmonary disease. [PDF]
, 2012 The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD).
Haczku, Angela
core +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Exiting the Outside World for Cross-Presentation [PDF]
Immunity, 2006 How are extracellular proteins cross-presented on MHC class I molecules? In this issue of Immunity, demonstrate that the ER-associated degradation (ERAD) export pathway operates in the phagosomes of dendritic cells and transfers antigens into the MHC class I pathway.
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Minimal-area metrics on the Swiss cross and punctured torus
, 2019 The closed string field theory minimal-area problem asks for the conformal metric of least area on a Riemann surface with the condition that all non-contractible closed curves have length at least 2\pi.
Headrick, Matthew, Zwiebach, Barton
core +1 more source
A novel myeloid cell in murine spleen defined through gene profiling [PDF]
, 2019 A novel myeloid antigen presenting cell can be generated through in vitro haematopoiesis in long-term splenic stromal cocultures. The in vivo equivalent subset was recently identified as phenotypically and functionally distinct from the spleen subsets of
Dabiri GA +5 more
core +1 more source
Antigen cross‐presentation: proteasome location, location, location [PDF]
The EMBO Journal, 2019 Our understanding of the mechanisms by which peptides from proteins present in phagosomes and endosomes are processed and presented on MHC class I molecules, in a pathway called cross-presentation, is still incomplete. One of the main questions arising from currently proposed models is how do proteins in the phagosome lumen reach the proteasome in the ...
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Immunology, 2018 Mycoplasma fermentans-derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) 2/TLR6. Short proteolytic products including macrophage-activating lipopeptide 2 (MALP2) have been utilized as antitumor immune ...
Yohei Takeda +5 more
doaj +1 more source
The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2 [PDF]
, 2016 Plasmacytoid dendritic cells (DCs [pDCs]) develop from pre-pDCs, whereas two lineages of conventional DCs (cDCs; cDC1s and cDC2s) develop from lineage-committed pre-cDCs.
Bachem +64 more
core +2 more sources