Results 211 to 220 of about 519,305 (288)

Fungal immunization potentiates CD4⁺ T cell-independent cDC2 responses for cross-presentation. [PDF]

Front Immunol
Kulkarni NA, Nanjappa SG.
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Alkaline Adjuvant Regulates Proteolytic Activity of Macrophages for Antigen Cross-Presentation and Potentiates Radioimmunotherapy. [PDF]

Adv Mater
Li B, Tan Y, Lei JH, Deng M, Yu X, Wang X, Lei LM, He L, Deng CX, Dai Y.   +9 more
europepmc   +1 more source

A novel myeloid cell in murine spleen defined through gene profiling [PDF]

, 2019
Dabiri GA, Ghosh S, Helen C. O’Neill, Schiopu A, Terence J. O’Neill, Ying‐Ying Hey   +5 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization. [PDF]

NPJ Vaccines
Zarnegar B, Carow B, Eriksson J, Spennare E, Öhlund P, Akpinar E, Bringeland E, Osterman IL, Lundqvist L, Antti J, Handin N, Helgesson PH, Bankefors J, Lövgren Bengtsson K, Sellin ME, Palm AE, Stertman L, Lunderius Andersson C.   +17 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2. [PDF]

J Exp Med
Jo S, Ohara RA, Theisen DJ, Kim S, Liu T, Bullock CB, He M, Ou F, Chen J, Piersma SJ, Postoak JL, Yokoyama WM, Diamond MS, Murphy TL, Murphy KM.   +14 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer. [PDF]

J Immunother Cancer
Yang Y, Tian X, Chen J, Liu J, Jiang H, Liu L, Qu S, Wu M, Wang J, Chen Y, He S, Sun C, Huang Y, Wang H.   +13 more
europepmc   +1 more source