Results 71 to 80 of about 14,888,742 (175)
Small, Volume 22, Issue 53, 21 September 2026.A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga +16 more
wiley +1 more source
RNA‐Protein Assemblies: A Review of Biophysical Principles and Coarse‐Grained Modeling Approaches
WIREs RNA, Volume 17, Issue 5, September/October 2026.RNA‐protein assemblies in the nucleolus, nuclear speckles, and viral ribonucleoprotein complexes are governed by multivalent IDR‐RNA interactions that drive liquid–liquid phase separation. This review examines the molecular grammar underlying these systems and critically evaluates coarse‐grained computational frameworks for modeling their sequence ...
Muhammad Waleed Iqbal, Patrick R. Onck
wiley +1 more source
Cryo-ET raw images and tilt series used for the published 3D structures shown in the figures of the paper entitled "Angle Between DNA Linker and Nucleosome Core Particle Regulates Array Compaction by Individual-Particle Cryo-Electron Tomography"
Jianfang Liu (13988585) +6 more
core +1 more source
Interview With Barbara Pearse and the Clathrin Family Tree
Traffic, Volume 27, Issue 3, September 2026.The clathrin family tree. Timeline of research on clathrin leading to and generated by Barbara Pearse's discovery, with milestones mapped onto the clathrin triskelion.
Frances M. Brodsky, Margaret S. Robinson
wiley +1 more source
Reproducible Sample Preparation of Virus-Infected Cells for Cryo-FIB/ET Using Manual Plunge Freezing
Bio-ProtocolMost viruses extensively remodel their host cells to establish productive infection. Visualization of virus-induced cellular remodeling by electron microscopy (EM) has been revolutionized in recent years by advances in cryo-focused ion beam (cryo-FIB ...
Nathalie Lavoie, Ekaterina Heldwein
doaj +1 more source
PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy
eLife, 2019 Cryo-electron tomography (cryo-ET) is emerging as a revolutionary method for resolving the structure of macromolecular complexes in situ. However, sample preparation for in situ Cryo-ET is labour-intensive and can require both cryo-lamella preparation ...
Sergey Gorelick +8 more
doaj +1 more source
Functional Specialization of Clathrin‐Independent Endocytic Routes: Mechanisms and Cellular Roles
Traffic, Volume 27, Issue 3, September 2026.Distinct clathrin‐independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com. ABSTRACT Clathrin‐independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin‐mediated endocytosis.
Andrea Francesco Benvenuto +5 more
wiley +1 more source
Conformational landscapes in cryo-ET data based on MD simulations
Cryo-electron tomography (cryo-ET) provides a unique window into molecular organization in cellular environments (in situ). However, the interpretation of molecular structural information is complicated by several intrinsic properties of cryo-ET data ...
Jonic, Slavica
core +1 more source
Automated removal of corrupted tilts in cryo-electron tomography
Journal of Structural Biology: XCryo-electron tomography (cryo-ET) enables the visualization of macromolecular structures in their near-native cellular environment. However, acquired tilt series are often compromised by image corruption due to drift, contamination, and ice reflections.
Tomáš Majtner, Beata Turoňová
doaj +1 more source
Expanding the Toolkit for Structural Cell Biology with ExoSloNano [PDF]
Structural DynamicsIn situ cryo-Electron Microscopy (cryo-EM) enables the direct interrogation of structure-function relationships by resolving macromolecular structures in their native cellular environment.
Lindsey N Young +10 more
doaj +1 more source