Results 101 to 110 of about 7,727 (171)

Editorial: Advances in brain tumors diagnosis and treatment [PDF]

, 2023
de Biase D., Franceschi E., Marucci G.
core   +1 more source

Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology

Angewandte Chemie, Volume 138, Issue 14, 27 March 2026.
We develop Cu+‐ and Cu2+‐specific DNAzyme fluorescent probes to visualize both copper redox states in living neurons. Aβ oligomers cause intracellular copper overload, triggering FDX1 dependent cuproptosis and generating ROS. This work links copper redox imbalance with Aβ pathology and offers a selective, sensitive way to monitor copper homeostasis in ...
Xiangli Shao, Zhenglin Yang, Zhihao Xu, Weijie Guo, Whitney Lewis, Boyi Gan, Yi Lu   +6 more
wiley   +1 more source

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis

Communications Biology
Cuproptosis, a copper-triggered cell death pathway, holds therapeutic potential for cancers, but its regulatory mechanisms in hepatocellular carcinoma (HCC) remain undefined.
Chutian Wu, Linjing Long, Min Wang, Lianli Shen, Jianjun Hu, Huijun Tang, Shufen Feng, Xiongxiu Liu, Ying Shi, Shaohui Tang, Yanfang Chen   +10 more
doaj   +1 more source

A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death [PDF]

, 2023
Carragher, Neil O, Elliott, Richard, Hughes, Becka, Munro, Alison   +3 more
core   +2 more sources

Identification of potential biomarkers of cuproptosis in cerebral ischemia [PDF]

ObjectiveCerebral ischemia can cause mild damage to local brain nerves due to hypoxia and even lead to irreversible damage due to neuronal cell death. However, the underlying pathogenesis of this phenomenon remains unclear.
Lihua Qin, Lihua Qin, Sheng Li, Tengjia Huang, Xi Cao, Yixin Liu   +5 more
core   +1 more source

Editorial: The impact of genetics on CRC therapy: from adaptive mutability to drug resistance [PDF]

, 2023
Crisafulli, Giovanni, Siravegna, Giulia
core   +1 more source

Editorial: Neurotoxins in Alzheimer\u27s disease and other dementias [PDF]

Alzheimer\u27s disease (AD) and other dementias are neurodegenerative disorders characterized by a progressive decline in cognition and independence from activities of daily living.
Fernando, Binosha, Hascup, Kevin N., Henriques, Alexandre, Poindron, Philippe L. L.   +3 more
core   +1 more source

Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer

Cellular & Molecular Biology Letters
Background Cuproptosis is a unique copper-dependent form of cell death that is highly correlated with the metabolic state of cells. Triptolide exerts pharmacological activity by altering the regulation of metal ions.
Yanxia Xiao, Jiameng Yin, Pu Liu, Xin Zhang, Yajun Lin, Jun Guo   +5 more
doaj   +1 more source

Penicillamine ameliorates intestinal barrier damage in dextran sulfate sodium-induced experimental colitis mice by inhibiting cuproptosis [PDF]

BackgroundCuproptosis is a copper-dependent form of cell death. However, its role in ulcerative colitis (UC) remains unknown.AimTo investigate whether cuproptosis is involved in UC and whether penicillamine (PA) improves colitis in mice by inhibiting ...
Chen Chen, Jiaze Ma, Shuangshuang Wang, Tuo Chen, Wenwen Tang, Yang Li, Yang Li, Yimeng Ma, Yugen Chen   +8 more
core   +1 more source

Editorial: Stromal and immune microenvironment in breast cancer metastasis. [PDF]

, 2022
Lu, Xin, Liu, Xia, Celià-Terrassa, Toni, Ren, Guangwen   +3 more
core   +3 more sources