Results 101 to 110 of about 7,425 (214)

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer

Signal Transduction and Targeted Therapy
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependent form ...
Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le, Yating Dian, Furong Zeng, Xiang Chen, Guangtong Deng   +9 more
doaj   +1 more source

The Marriage of Metal Nanoclusters With Reticular Frameworks: Synthetic Strategies and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of metal nanoclusters (MNCs) with reticular frameworks (RFs) has recently emerged as a powerful strategy to create composite materials with enhanced and synergistic functionalities. This review provides an overview of the synthetic strategies developed for constructing MNCs/RFs composites and their recent advances in biomedical ...
Wenfeng Liu, Qinyin Yin, Li‐Li Tan, Li Shang   +3 more
wiley   +1 more source

Metabolic Cell Death in Cancer: Ferroptosis, Cuproptosis, Disulfidptosis, and Beyond [PDF]

Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism.
Gan, Boyi, Mao, Chao, Wang, Min, Zhuang, Li   +3 more
core   +1 more source

 The Prognostic Potential of Cuproptosis and Cuproptosis-Related Alteration of Clear Cell Renal Cell Carcinoma

, 2022
Abstract Aim To study whether the novel copper ionophores induced cell death would impact the prognosis of clear cell renal cell carcinoma (ccRCC) and subsequently influence the tumor microenvironment (TME). Methods The differential expression of 10 cuproptosis and 40 TME-pathway-related genes were measured between 531 tumor samples and 71 ...
Zhaoyu Xing, Li Cui, Yuehua Feng, Yang Yang, Xiaozhou He   +4 more
openaire   +1 more source

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han, Iris S. Weitz, Hasan Slika, Betty Tyler, Andrew J. Steckl   +4 more
wiley   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application

MedComm, Volume 7, Issue 2, February 2026.
Hydrogels offer an innovative platform for cancer immunotherapy. Through tailorable crosslinking strategies, they form customizable drug delivery platforms that address diverse therapeutic requirements by loading specific immunotherapeutic agents. These systems demonstrate significant clinical potential for precise tumor immunotherapy.
Xiaohua Chen, Shan Wu, Yueyang Zhang, Lilu Feng, Yang Chen, Xuzhao Yang, Ke Men, Jiuqun Zhu, Ming Li   +8 more
wiley   +1 more source

Spojevi bis(amino acidato)bakra(II) u krvnoj plazmi – pregled računalno predviđenih strukturnih svojstva i afiniteta vezanja aminokiselina s Cu2+ radi moguće primjene u farmakološkim istraživanjima [PDF]

Neutral bis(amino acidato)copper(II) [Cu(aa)2] coordination compounds are the physiological species of copper(II) amino acid compounds in blood plasma taking the form of bis(l-histidinato)copper(II) and mixed ternary copper(II)-l-histidine complexes ...
Sabolović, Jasmina
core   +2 more sources

Epigallocatechin Gallate Promotes Cuproptosis via the MTF1/ATP7B Axis in Hepatocellular Carcinoma

Cells
Background: Cuproptosis is a form of copper-dependent non-apoptotic cell death. Cancer cells that prefer to use aerobic glycolysis for energy generation are commonly insensitive to cuproptosis, which hinders its application for cancer treatment ...
Yuhan Fu, Lirui Hou, Kai Han, Chong Zhao, Hongbo Hu, Shutao Yin   +5 more
doaj   +1 more source