Results 111 to 120 of about 7,425 (214)
Experimental Physiology, Volume 111, Issue 2, Page 539-555, 1 February 2026.Abstract Recent studies highlight the important roles of cuproptosis in cancer cells. However, the roles of the cuproptosis‐related genes (CRGs) in different cancers are still not fully understood. Comprehensive analysis was performed using open‐source bioinformatic platforms to disclose the expression profiles, prognostic significance, genomic and ...
Xinyu Ge +10 more
wiley +1 more source
The study on cuproptosis in Alzheimer’s disease based on the cuproptosis key gene FDX1
Frontiers in Aging NeuroscienceBackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory and cognitive impairments. Previous studies have shown neuronal death in the brains of AD patients, but the role of cuproptosis and its associated genes in AD neurons remains unclear.MethodsIntersection analysis was conducted using the AD transcriptome dataset ...
Guilin Chen +4 more
openaire +3 more sources
Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives
Journal of Hematology & OncologyCuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation of dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial ...
Chenliang Zhang +2 more
doaj +1 more source
Copper, Cuproptosis, and Neurodegenerative Diseases
International Journal of Molecular SciencesCopper is a vital micronutrient for animals and plants acting as a crucial cofactor in the synthesis of numerous metabolic enzymes and contributing to mitochondrial respiration, metabolism, oxido-reductive reactions, signal transmission, and oxidative and nitrosative damage.
Giuseppe Genchi +4 more
openaire +1 more source
Editorial: Advances in brain tumors diagnosis and treatment [PDF]
, 2023 de Biase D., Franceschi E., Marucci G.
core +1 more source
Identification of potential biomarkers of cuproptosis in cerebral ischemia [PDF]
ObjectiveCerebral ischemia can cause mild damage to local brain nerves due to hypoxia and even lead to irreversible damage due to neuronal cell death. However, the underlying pathogenesis of this phenomenon remains unclear.
Lihua Qin +5 more
core +1 more source
Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer
Cellular & Molecular Biology LettersBackground Cuproptosis is a unique copper-dependent form of cell death that is highly correlated with the metabolic state of cells. Triptolide exerts pharmacological activity by altering the regulation of metal ions.
Yanxia Xiao +5 more
doaj +1 more source
Cell Death DiscoveryAbstract Spermatogenesis, which is regulated by multiple cell death mechanisms, is an extremely complex process. The significance of cell death during spermatogenesis is a topic of interest because of its potential medical implications.
Junjun Li +10 more
openaire +2 more sources
Editorial: The impact of genetics on CRC therapy: from adaptive mutability to drug resistance [PDF]
, 2023 Crisafulli, Giovanni, Siravegna, Giulia
core +1 more source
A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death [PDF]
, 2023 Carragher, Neil O +3 more
core +2 more sources