Results 111 to 120 of about 7,727 (171)

Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis

Biomolecules
Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardiomyopathy, according to recent ...
Mohammad El-Nablaway, Hany M. A. Sonpol, Yaser Hosny Ali Elewa, Mohamed A. M. Ali, Mohamed Adel, Eman Serry Zayed, Maha Alhelf, Manar A. Didamoony, Amal Fahmy Dawood, Eman M. Embaby, Khaled S. El-Bayoumi, Wesam S. El-Saeed   +11 more
doaj   +1 more source

Cuproptosis and its potential role in musculoskeletal disease [PDF]

Cuproptosis, a recently identified form of copper-dependent cell death, arises from intracellular copper dyshomeostasis. As an essential trace element, copper plays a critical role in bioenergetic metabolism, redox regulation, and synaptic transmission ...
Aoshuang Xu, Honglin Wang, Huiling Mei, Ji Rao, Lin Lu, Wentao Zhang, Xiaoyue Yao, Ziyang Xiang   +7 more
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Comprehensive analysis and validation of the prognostic significance of cuproptosis-related genes in rectal adenocarcinoma

Frontiers in Cell and Developmental Biology
BackgroundRectal adenocarcinoma has a high incidence and suboptimal therapeutic outcomes. Notably, reliable prognostic biomarkers are currently lacking.
Tianhao Li, Tianhao Li, Xinyu Gao, Xinyu Gao, Shuocun Zhang, Haoren Jing, Haoren Jing, Haoren Jing, Zhicheng Pu, Zhicheng Pu, Zhicheng Pu, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Mingqing Zhang, Mingqing Zhang, Mingqing Zhang   +16 more
doaj   +1 more source

Cuproptosis-related genes and agents: implications in tumor drug resistance and future perspectives [PDF]

In the field of tumor treatment, drug resistance remains a significant challenge requiring urgent intervention. Recent developments in cell death research have highlighted cuproptosis, a mechanism of cell death induced by copper, as a promising avenue ...
Bin Zhang, Bin Zhang, Daizhou Zhang, Daizhou Zhang, Lingwen Xu, Lingwen Xu, Wenjie Ren, Wenjie Ren, Wentao Liu, Wentao Liu, Xiangyu Kong, Xiangyu Kong, Xiaolan Cao, Xinzhi Li, Xinzhi Li, Xuan Tang, Xuan Tang, Yuxiao Deng, Yuxiao Deng   +18 more
core   +1 more source

Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy

Nature Communications
Cuproptosis is an emerging mode of programmed cell death for tumor suppression but sometimes gets resisted by tumor cells resist under specific mechanisms.
Meng Guan, Kai Cheng, Xiao-Ting Xie, Yong Li, Meng-Wen Ma, Bin Zhang, Si Chen, Wei Chen, Bo Liu, Jin-Xuan Fan, Yuan-Di Zhao   +10 more
doaj   +1 more source

Advancing precision oncology:Molecular insights and personalized therapeutic strategies in gastrointestinal cancers [PDF]

Gastrointestinal (GI) cancers, including esophageal adenocarcinoma, pancreatic ductal adenocarcinoma, and colorectal cancer, are among the most common and challenging cancers.
Dings, M.P.G.
core  

Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning [PDF]

Background and aimsCuproptosis has emerged as a significant contributor in the progression of various diseases. This study aimed to assess the potential impact of cuproptosis-related genes (CRGs) on the development of hepatic ischemia and reperfusion ...
Fang Xiao, Fang Xiao, Fang Xiao, Guandou Yuan, Guandou Yuan, Guandou Yuan, Guoqing Ouyang, Guoqing Ouyang, Guoqing Ouyang, Guozhen Huang, Guozhen Huang, Guozhen Huang, Shuangjiang Li, Shuangjiang Li, Shuangjiang Li, Songqing He, Songqing He, Songqing He, Stephen Tomlinson, Yong Wang, Yong Wang, Yong Wang, Yonglian Zeng, Yonglian Zeng, Yonglian Zeng, Zhi Tan, Zhi Tan, Zhi Tan, Zhipeng Liu, Zhipeng Liu, Zhipeng Liu   +30 more
core   +1 more source

Cuproptosis-driven nanostrategies: Synergistic nanoplatforms for tumor microenvironment reprogramming and enhanced anticancer efficacy

Materials Today Bio
Cuproptosis, a novel copper-dependent regulated cell death mechanism, represents a paradigm shift in oncology by exploiting unique copper dyshomeostasis mechanisms to combat intractable malignancies.
Haipeng Cheng, Lin Zhao, Jing Cai
doaj   +1 more source

Identification of cuproptosis-related genes in Alzheimer’s disease based on bioinformatic analysis

European Journal of Medical Research
Objective To explore the role of cuproptosis in Alzheimer’s disease (AD). Methods An AD-related microarray dataset was downloaded from the Gene Expression Omnibus (GEO) database (GSE140830).
Ming-ming Ma, Jing Zhao, Ling Liu, Cai-ying Wu   +3 more
doaj   +1 more source

Wilson Disease: Why Early Diagnosis Matters and How to Improve Screening

Wilson disease is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene, leading to copper accumulation in the liver, brain, and other organs.
Charzewski, Piotr, Starzyk, Agnieszka
core   +1 more source