Results 71 to 80 of about 88,618 (194)

Effective Treatments for Bladder Cancer Affecting CXCL9/CXCL10/CXCL11/ CXCR3 Axis: A Review

Oman Medical Journal, 2020
Bladder cancer (BC) originates mainly from the epithelial compartment of the bladder, which is defined as transitional cell carcinoma or urothelial cell carcinoma. About 70% of patients with BC will survive five years from diagnosis.
Alireza Nazari, Zahra Ahmadi, Gholamhossein Hassanshahi, Mitra Abbasifard6, Zahra Taghipour, Soudeh Khanamani Falahati-pour, Hossein Khorramdelazad   +6 more
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The CXCL10/CXCR3 axis in acute respiratory distress syndrome [PDF]

Jichu yixue yu linchuang
The CXC chemokine ligand-10/CXC receptor-3 (CXCL10/CXCR3) axis, a crucial pathway mediating Th1-type immunity, substantially contributes to the development of acute respiratory distress syndrome(ARDS) by enhancing inflammatory storms.
SHENG Qi, TONG Jin
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Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis.

, 2011
Statins have been reported to exert anti-inflammatory actions and protect against septic organ dysfunction. Herein, we hypothesized that simvastatin may attenuate neutrophil activation and lung damage in abdominal sepsis.
Rahman, Milladur,, Rahman, Milladur, Zhongquan Qi, Thorlacius, Henrik,, Thorlacius, Henrik, Su Zhang, Milladur Rahman, Songen Zhang, Zhang, Su,, Zhang, Su, Zhang, Songen, Lund University., Qi, Zhongquan, Henrik Thorlacius   +13 more
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CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway

Journal of Lipid Research, 2019
CXC chemokine ligand 12 (CXCL12) is a member of the CXC chemokine family and mainly acts on cell chemotaxis. CXCL12 also elicits a proatherogenic role, but the molecular mechanisms have not been fully defined yet.
Jia-Hui Gao, Lin-Hao He, Xiao-Hua Yu, Zhen-Wang Zhao, Gang Wang, Jin Zou, Feng-Jiao Wen, Li Zhou, Xiang-Jun Wan, Da-Wei Zhang, Chao-Ke Tang   +10 more
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CXC chemokine receptor 2 contributes to host defense in murine urinary tract infection [PDF]

, 2001
CXC chemokines have been implicated in the recruitment of neutrophils to sites of infection. To determine the role of CXC chemokines in the host response to urinary tract infection (UTI), female mice were treated with an antibody against the major CXC ...
Speelman, P., Strieter, R.M., Sewnath, M.E., van Deventer, S. J., van der Poll, T., van Deventer, S.J.H., Olszyna, D. P., Strieter, R. M., Florquin, S., Sewnath, M., Olszyna, D.P., Branger, J.   +11 more
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A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor 4

, 2003
We have synthesized the CXC chemokine receptor 4(29-39) peptide. This peptides is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived ...
PEDONE, CARLO, ROSSI, FILOMENA, BENEDETTI, ETTORE, Ragone R., Palladino P., Saviano M.   +5 more
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Chemotactic Cues for NOTCH1-Dependent Leukemia

Frontiers in Immunology, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Erich Piovan, Erich Piovan, Valeria Tosello, Alberto Amadori, Alberto Amadori, Paola Zanovello, Paola Zanovello   +6 more
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Feline peripheral blood mononuclear cells express message for both CXC and CC type chemokine receptors

, 1999
well as primary binding of virus to the CD4 receptor, entry and infection of cells requires coreceptors which are members of the chemokine group of G-protein coupled receptors.
Kovacs, E. M., Robinson, W. F., Baxter, G. D.   +2 more
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Cutting Edge: Activity of Human Adult Microglia in Response to CC Chemokine Ligand 21

, 2004
The approximately 50 known chemokines are classified in distinct subfamilies: CXC, CC, CX3C, and C. Although the signaling of chemokines often is promiscuous, signaling events between members of these distinct chemokine classes are hardly observed.
Hulshof, Sandra, Dijkstra, Ineke M., Van Der Valk, Paul, Biber, Knut, Boddeke, Hendrikus W. G. M.   +4 more
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TRIM proteins and CXS chemokines : evolutionary dynamics and functional characterization of two large protein families in teleost fish [PDF]

, 2012
Two large protein families with roles in the immune system were the subject of this thesis. In part one of the thesis, TRIM proteins were studied, which are part of an ancient intracellular immune system. In mammals, TRIM proteins were recently found to
Aa, L.M., van der
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