Results 131 to 140 of about 42,965 (221)

CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma. [PDF]

Cell Oncol (Dordr)
Wang J, Zhou Y, Han X, Zhao Y, Chen A, Chen Y, Zhang S, Lv Y, Wang L.   +8 more
europepmc   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

CD30 Expression in Neoplastic Mast Cells and the Presence of CD30+, CD3+, and PAX‐5+ Tumour‐Infiltrating Lymphocytes as Prognostic Markers in Canine Cutaneous Mast Cell Tumours

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Canine cutaneous mast cell tumour (MCT) is the most common skin neoplasm in dogs, with histopathology serving as both the diagnostic and primary prognostic tool. However, identifying reliable biomarkers is essential for improving clinical decision‐making.
Fernanda Ramalho Ramos, Janayna Maria Parente Serafim, Bethânia Almeida Gouveia, Pedro Luiz Porfirio Xavier, Juliano Rodrigues Sangalli, Heidge Fukumasu, Ricardo de Francisco Strefezzi   +6 more
wiley   +1 more source

The predictive diagnostic value of combined serum detection of CXCL12, VEGF, and CA125 for endometriosis. [PDF]

Medicine (Baltimore)
Xu H, Xie Z, Zheng Y, Wang C.
europepmc   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Partial Deletion of <i>Cxcl12</i> from Hippocampal Cajal-Retzius Cells Does Not Disrupt Dentate Gyrus Development or Neurobehaviors. [PDF]

eNeuro
van Bruggen R, Manzanet Freyre K, Vasanthkumar S, Wang M, Tan Q.   +4 more
europepmc   +1 more source

TIMP1 Links Extracellular Matrix Remodeling With Immune Contexture and Outcome in Head and Neck Squamous Cell Carcinoma

Oral Science International, Volume 23, Issue 2, May 2026.
ABSTRACT Objective Tissue inhibitor of metalloproteinase‐1 (TIMP1) is a secreted glycoprotein that controls matrix metalloproteinase activity and exerts pleiotropic signaling functions. We investigated the clinical relevance of TIMP1 in head and neck squamous cell carcinoma (HNSCC; TCGA‐HNSC), focusing on survival, immunologic contexture, pathway ...
Aiko Kurosaka, Kenichi Kumagai, Kazuto Hoshi   +2 more
wiley   +1 more source

DPCDI: an artificial intelligent-derived indicator interpreting the diagnostic, stratification, and therapeutic implications of druggability programmed cell death in heart failure. [PDF]

Front Genet
Zhang L, Zhu Y, Fang Y, Yang Y, Yu Y, Wang H, Jiang X, Zhang X, Huang D.   +8 more
europepmc   +1 more source

Atypical metastatic osteosarcoma pattern in a dog: Lymphatic, neurovascular and subcutaneous metastasis

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 6‐year‐old, spayed, female labrador retriever was presented with left distal radial swelling. Imaging, cytology and biopsy identified an aggressive radial lesion with metastasis to the left axillary lymph node, and a diagnosis of presumptive osteosarcoma was made.
Veronica Perez‐Rodriguez, Laura Venner, Rowan Milner, Jishnu Rao Gutti, Elizabeth A. Maxwell   +4 more
wiley   +1 more source