Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain [PDF]
, 2016 Xin Luo +6 more
openalex +1 more source
MiR-126 Suppresses Colitis-Associated Colorectal Cancer by Regulating Crosstalk Between Epithelium Cells and Macrophages via CXCL12 [PDF]
, 2020 Shuai Wu +5 more
openalex +1 more source
Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes
Advanced Science, EarlyView.Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako +16 more
wiley +1 more source
Advanced Science, EarlyView.A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Jianghao Shen +5 more
wiley +1 more source
Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. [PDF]
, 2019 Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood.
Cyster, Jason G +4 more
core +1 more source
Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7 [PDF]
, 2018 Jia‐Yi Zheng +2 more
openalex +1 more source
Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer [PDF]
, 2022 Isabel Heidegger +22 more
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Advanced Science, EarlyView.CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng +12 more
wiley +1 more source
The Journal of Headache and PainBackground Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain transitions from acute to chronic is crucial for effective management.
Shi-Ze Leng +16 more
doaj +1 more source