Results 11 to 20 of about 42,965 (221)

CXCL12 and [N33A]CXCL12 in 5637 and HeLa cells: regulating HER1 phosphorylation via calmodulin/calcineurin. [PDF]

PLoS ONE, 2012
In the human neoplastic cell lines 5637 and HeLa, recombinant CXCL12 elicited, as expected, downstream signals via both G-protein-dependent and β-arrestin-dependent pathways responsible for inducing a rapid and a late wave, respectively, of ERK1/2 ...
Antonella Rigo, Michele Gottardi, Ernesto Damiani, Massimiliano Bonifacio, Isacco Ferrarini, Pierluigi Mauri, Fabrizio Vinante   +6 more
doaj   +6 more sources

CXCL14 antagonizes the CXCL12-CXCR4 signaling axis

Biomolecular Concepts, 2014
CXCL12 and CXCL14 are evolutionarily conserved members of the CXC-type chemokine family. CXCL12 binds specifically to the G-protein-coupled receptor CXCR4 to induce the migration of primordial germ cells, hematopoietic stem cells, and inflammation ...
Hara Takahiko, Tanegashima Kosuke
doaj   +3 more sources

CXCL12/SDF-1 in IgG4-Related Disease [PDF]

Frontiers in Pharmacology, 2021
Background: SDF-1/CXCL12 is a chemokine with pleiotropic functions in hematopoietic stem cell niche homeostasis, germinal center architecture, B cell maturation, neoangiogenesis, and fibrosis. Recently, the CXCL12/CXCR4/CXCR7 axis was associated with cancer metastasis and autoimmune diseases.
Capecchi R., Croia C., Puxeddu I., Pratesi F., Cacciato A., Campani D., Boggi U., Morelli L., Tavoni A., Migliorini P.   +9 more
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mTORC2 mediates CXCL12-induced angiogenesis [PDF]

Angiogenesis, 2016
The chemokine CXCL12, through its receptor CXCR4, positively regulates angiogenesis by promoting endothelial cell (EC) migration and tube formation. However, the relevant downstream signaling pathways in EC have not been defined. Similarly, the upstream activators of mTORC2 signaling in EC are also poorly defined.
Ziegler, Mary E, Hatch, Michaela MS, Wu, Nan, Muawad, Steven A, Hughes, Christopher CW   +4 more
openaire   +4 more sources

Glycosaminoglycan silencing by engineered CXCL12 variants [PDF]

FEBS Letters, 2015
We have engineered GPCR (G protein‐coupled receptor) knock‐out and high GAG‐binding affinity into CXCL12α to inhibit CXCL12α‐induced cell migration. Compared to wtCXCL12, the mutant CXCL12α (Δ8 L29K V39K) exhibited a 5.6‐fold and a 2.2‐fold affinity increase for heparin and heparan sulfate, respectively.
Gschwandtner M, Trinker MU, Hecher B, Adage T, Ali S, Kungl AJ   +5 more
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CXCL12 inhibits hair growth through CXCR4

Biomedicine & Pharmacotherapy, 2022
CXCL12 and its receptors, which are highly expressed in the skin, are associated with various cutaneous diseases, including androgenic alopecia. However, their expression and role during the hair cycle are unknown. This study aims to investigate the expression of CXCL12 and its receptor, CXCR4, in the vicinity of hair follicles and their effect on hair
Mei, Zheng, Sang Ho, Oh, Nahyun, Choi, Yong Jin, Choi, Jino, Kim, Jong-Hyuk, Sung   +5 more
openaire   +3 more sources

Fragment-Based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction [PDF]

Current Topics in Medicinal Chemistry, 2013
The chemokine CXCL12 and its G protein-coupled receptor (GPCR) CXCR4 are high-priority clinical targets because of their involvement in metastatic cancers (also implicated in autoimmune disease and cardiovascular disease). Because chemokines interact with two distinct sites to bind and activate their receptors, both the GPCRs and chemokines are ...
Joshua J, Ziarek, Yan, Liu, Emmanuel, Smith, Guolin, Zhang, Francis C, Peterson, Jun, Chen, Yongping, Yu, Yu, Chen, Brian F, Volkman, Rongshi, Li   +9 more
openaire   +2 more sources

Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation

Brazilian Journal of Radiation Sciences, 2019
Reduction of nitric oxide (NO) production is related to increased survival in some models of infection and ionizing radiation (IR) exposure. The work used lethally irradiated (60Co, 8Gy) C57Bl6j mice, treated or not with aminoguanidine (AG), an inhibitor
Daniel Perez Vieira, Andrés Jimenez Galisteo Jr., Heitor Franco de Andrade Jr.   +2 more
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Enrichment of Cxcl12 promoter with TET2: A possible link between promoter demethylation and enhanced gene expression in the absence of PARP-1 [PDF]

Archives of Biological Sciences, 2019
Previously, we described the link between C-X-C motif chemokine 12 (Cxcl12) gene induction and DNA hypomethylation in the absence of poly(ADP-ribose) polymerase 1 (PARP-1).
Tolić Anja Z., Rajić Jovana J., Đorđević Marija B., Đorđević Miloš M., Dinić Svetlana S., Grdović Nevena M., Arambašić-Jovanović Jelena D., Mihailović Mirjana V., Poznanović Goran Đ., Jurkowski Tomasz P., Vidaković Melita S., Uskoković Aleksandra S.   +11 more
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STUDY OF CXCL12, CCR4, EGFR GENE EXPRESSION IN MIGRATING MYELOMONOBLASTIC LEUKEMIA CELLS BEFORE AND AFTER CHEMOTHERAPY

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Аim. A study of CXCL12 effect on the migration of mononuclear cells isolated from healthy patients, from patients with myelomonoblastic leukemia before and after chemotherapy and the study of CCR4, EGFR and CXCL12 genes expression after exposure to ...
A. B. Filina, O. A. Svitich, Yu. I. Ammur, A. K. Golenkov, E. F. Klinushkina, V. V. Zverev   +5 more
doaj   +1 more source