CXCL12 and [N33A]CXCL12 in 5637 and HeLa cells: regulating HER1 phosphorylation via calmodulin/calcineurin. [PDF]
PLoS ONE, 2012 In the human neoplastic cell lines 5637 and HeLa, recombinant CXCL12 elicited, as expected, downstream signals via both G-protein-dependent and β-arrestin-dependent pathways responsible for inducing a rapid and a late wave, respectively, of ERK1/2 ...
Antonella Rigo +6 more
doaj +6 more sources
CXCL14 antagonizes the CXCL12-CXCR4 signaling axis
Biomolecular Concepts, 2014 CXCL12 and CXCL14 are evolutionarily conserved members of the CXC-type chemokine family. CXCL12 binds specifically to the G-protein-coupled receptor CXCR4 to induce the migration of primordial germ cells, hematopoietic stem cells, and inflammation ...
Hara Takahiko, Tanegashima Kosuke
doaj +3 more sources
CXCL12/SDF-1 in IgG4-Related Disease [PDF]
Frontiers in Pharmacology, 2021 Background: SDF-1/CXCL12 is a chemokine with pleiotropic functions in hematopoietic stem cell niche homeostasis, germinal center architecture, B cell maturation, neoangiogenesis, and fibrosis. Recently, the CXCL12/CXCR4/CXCR7 axis was associated with cancer metastasis and autoimmune diseases.
Capecchi R. +9 more
openaire +3 more sources
mTORC2 mediates CXCL12-induced angiogenesis [PDF]
Angiogenesis, 2016 The chemokine CXCL12, through its receptor CXCR4, positively regulates angiogenesis by promoting endothelial cell (EC) migration and tube formation. However, the relevant downstream signaling pathways in EC have not been defined. Similarly, the upstream activators of mTORC2 signaling in EC are also poorly defined.
Ziegler, Mary E +4 more
openaire +4 more sources
Interferon regulatory factor 8-deficiency determines massive neutrophil recruitment but T cell defect in fast growing granulomas during tuberculosis [PDF]
, 2013 Following Mycobacterium tuberculosis (Mtb) infection, immune cell recruitment in lungs is pivotal in establishing protective immunity through granuloma formation and neogenesis of lymphoid structures (LS).
A Dorhoi +58 more
core +10 more sources
CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]
, 2016 BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus +5 more
core +1 more source
Glycosaminoglycan silencing by engineered CXCL12 variants [PDF]
FEBS Letters, 2015 We have engineered GPCR (G protein‐coupled receptor) knock‐out and high GAG‐binding affinity into CXCL12α to inhibit CXCL12α‐induced cell migration. Compared to wtCXCL12, the mutant CXCL12α (Δ8 L29K V39K) exhibited a 5.6‐fold and a 2.2‐fold affinity increase for heparin and heparan sulfate, respectively.
Gschwandtner M +5 more
openaire +3 more sources
CXCL12 inhibits hair growth through CXCR4
Biomedicine & Pharmacotherapy, 2022 CXCL12 and its receptors, which are highly expressed in the skin, are associated with various cutaneous diseases, including androgenic alopecia. However, their expression and role during the hair cycle are unknown. This study aims to investigate the expression of CXCL12 and its receptor, CXCR4, in the vicinity of hair follicles and their effect on hair
Mei, Zheng +5 more
openaire +3 more sources
The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]
, 2013 Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
A Dar +47 more
core +1 more source
CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]
, 2017 The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian +17 more
core +1 more source