Evaluation of the Expression Levels of Notch Signaling Pathway-Related Genes; JAG1, CXCR4, and MIB1 in Acute Myeloid Leukemia Patients [PDF]
Middle East Journal of Cancer, 2022 Background: Acute myeloid leukemia (AML) is a complex disease characterized by clonal expansion of undifferentiated myeloid precursors, resulting in impaired hematopoiesis and bone marrow failure.
Seyedeh Hananeh Ghafelehbashi +4 more
doaj +1 more source
Extracellular Hsp70 Is Involved in the CXCL12/CXCR4 Pathway in Primary Human Nasal Epithelial Cells: A Preliminary Study [PDF]
Journal of Rhinology, 2023 Background and Objectives To date, no studies have been conducted on the interaction between extracellular heat shock protein 70 (Hsp70) and C-X-C chemokine receptor type 4 (CXCR4) in the upper airway.
Seong Hee Kim +3 more
doaj +1 more source
CXCL12-CXCR4 axis: its role and the drug inhibitors on each type of cancers [PDF]
World Cancer Research Journal, 2022 Objective: Chemokine 12, C-X-C Motif Chemokine Ligand 12 (CXCL12), and its receptor C-X-C Motif Chemokine Ligand 4 (CXCR4), both play essential and critical roles in the development of different types of cancers.
A. Zarinkhat +5 more
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Aberrant regulation of CXCR4 in cancer via deviant microRNA-targeted interactions
Epigenetics, 2022 CXCR4 is involved in many facets of cancer, including being a major player in establishing metastasis. This is in part due to the deregulation of CXCR4, which can be attributed to many genetic and epigenetic mechanisms, including aberrant microRNA–CXCR4 ...
Alexei J. Stuckel +3 more
doaj +1 more source
Check update pattern of tumorigenic vasculature signature based on MMP9 and CXCR4 expression in locally advanced breast cancer [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Locally advanced breast cancers (LABC) are the most common women malignant tumors. Appropriate vasculature is required for tumor growth support, formed by involving protein signaling, including matrix metalloprotein 9 (MMP9) and C-X-C chemokine ...
Mochamad Bachtiar Budianto +3 more
doaj +1 more source
CXCR4: A Potential Chemokine Receptor for Future Regenerative Therapeutic Target [PDF]
Journal of Cell and Molecular Research, 2015 Understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics.
Asieh Heirani-Tabasi +1 more
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The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Kidney Diseases, 2021 Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song +3 more
doaj +1 more source
CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
Open Life Sciences, 2023 CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4 ...
Wu Xia, Wang Ying, Li Min
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Melittin Prevents Metastasis of Epidermal Growth Factor-Induced MDA-MB-231 Cells through The Inhibition of The SDF-1α/CXCR4 Signaling Pathway [PDF]
Cell Journal, 2022 Objective: Melittin is one of the natural components of bee venom (Apis mellifera), and its anticancer and antimetastatic properties have been well established, but the underlying mechanism remains elusive.
Fatemeh Salimian +2 more
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Journal of Microbiology and Infectious Diseases, 2023 Background: Tropism is determined by the ability of HIV-1 to bind to the receptors CCR5 or CXCR4 to enter the target cell, which has implications for the pathogenesis of the disease and affects treatment options.
Anamary Suarez Batista +11 more
doaj +1 more source