Results 11 to 20 of about 157,119 (339)

CXCR4-targeted theranostics in oncology

European Journal of Nuclear Medicine and Molecular Imaging, 2022
AbstractA growing body of literature reports on the upregulation of C-X-C motif chemokine receptor 4 (CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for molecular imaging and endoradiotherapy in a theranostic setting.
Buck, Andreas K., Serfling, Sebastian E., Lindner, Thomas, Hänscheid, Heribert, Schirbel, Andreas, Hahner, Stefanie, Fassnacht, Martin, Einsele, Hermann, Werner, Rudolf A.   +8 more
openaire   +4 more sources

CXCR4 Ligands: The Next Big Hit? [PDF]

Journal of Nuclear Medicine, 2017
The G protein-coupled protein receptor C-X-C chemokine receptor 4 (CXCR4) is an attractive target for cancer diagnosis and treatment, as it is overexpressed in many solid and hematologic cancers. Binding of its ligand, C-X-C chemokine ligand 12 (CXCL12), results in receptor internalization and activation of several signal transduction pathways, such as
Walenkamp, Annemiek M.E., Lapa, Constantin, Herrmann, Ken, Wester, Hans-Jürgen   +3 more
openaire   +3 more sources

CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications

International Journal on Biological Sciences, 2023
Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or epigenetic changes, and is the biggest challenge around the world. Cytokines, including chemokines, exhibit expression changes and disorders in all human cancers. These
Yaru Yang, Jiayan Li, Wangrui Lei, Haiying Wang, Yun-feng Ni, Yanqing Liu, Huanle Yan, Yifan Tian, Zheng Wang, Zhi Yang, Shulin Yang, Yang Yang, Qiang Wang   +12 more
semanticscholar   +1 more source

CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy

Cancers, 2022
Simple Summary Chemokines are small soluble proteins that control and regulate cell trafficking within and between tissues by binding to their receptors.
R. Mezzapelle, Manuela Leo, Francesca Caprioglio, L. Colley, Andrea Lamarca, L. Sabatino, V. Colantuoni, M. Crippa, M. Bianchi   +8 more
semanticscholar   +1 more source

CXCL12-CXCR4/CXCR7 Axis in Colorectal Cancer: Therapeutic Target in Preclinical and Clinical Studies

International Journal of Molecular Sciences, 2021
Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as C-X-C motif chemokine 12 (CXCL12), a prognostic factor, is an extracellular ...
Tripti Khare, M. Bissonnette, S. Khare
semanticscholar   +1 more source

CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment

Frontiers in Oncology, 2021
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers.
S. Santagata, C. Ieranò, A. Trotta, Anna Capiluongo, Federica Auletta, G. Guardascione, S. Scala   +6 more
semanticscholar   +1 more source

Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration [PDF]

Cancer Biology & Therapy, 2013
The stromal cell-derived factor-1α SDF-1α (CXCL12)/CXCR4 axis has been linked to poor prognosis in some cancers. As histone deacetylase inhibitors (HDIs) exert antitumor effects by targeting proteins affecting cell migration, we sought to evaluate the effects of the HDIs apicidin, vorinostat, entinostat (MS-275) and romidepsin on the expression and ...
Caterina, Ierano, Agnes, Basseville, Kenneth K W, To, Zhirong, Zhan, Robert W, Robey, Julia, Wilkerson, Susan E, Bates, Stefania, Scala   +7 more
openaire   +2 more sources

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. [PDF]

, 2015
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL).
Ale-Ali, Amine, Amaya-Chanaga, Carlos I, Cardarelli, Pina M, Castro, Januario E, Choi, Michael Y, Cohen, Lewis J, Jones, Harrison, Kashyap, Manoj K, Kipps, Thomas J, Kuhne, Michelle R, Kumar, Deepak, Melo-Cardenas, Johanna, Rassenti, Laura Z, Sabbatini, Peter, Shelat, Suresh G   +14 more
core   +4 more sources

Tropism prediction in HIV-1 variants circulating in Cuba, 2017-2019: Implications for the pathogenesis of infection and response to Maraviroc

Journal of Microbiology and Infectious Diseases, 2023
Background: Tropism is determined by the ability of HIV-1 to bind to the receptors CCR5 or CXCR4 to enter the target cell, which has implications for the pathogenesis of the disease and affects treatment options.
Anamary Suarez Batista, Lissette Perez Santos, Liuber Yans Machado Zaldívar, Melissa Mendez Gonzalez, Yanet Pintos Saavedra, Jorge Perez Ávila, Hector Manuel Díaz Torres, Tamara Rojas Nuñez, Juliet María Enriquez Puertas, Yoanna Baños Morales, Enrique Noa Romero, Vivian Kourí Cardella   +11 more
doaj   +1 more source

Melittin Prevents Metastasis of Epidermal Growth Factor-Induced MDA-MB-231 Cells through The Inhibition of The SDF-1α/CXCR4 Signaling Pathway [PDF]

Cell Journal, 2022
Objective: Melittin is one of the natural components of bee venom (Apis mellifera), and its anticancer and antimetastatic properties have been well established, but the underlying mechanism remains elusive.
Fatemeh Salimian, Mohammad Nabiuni, Ensieh Salehghamari   +2 more
doaj   +1 more source