Results 251 to 260 of about 157,119 (339)

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

G-CSF promotes H3K27ac-modified KLF5 to activate CXCR4 expression and drive colon cancer growth and metastasis. [PDF]

Eur J Med Res
Ma G, Jiang J, He T, Jin C, Wu W, Fan W, Wang T, Zhou P.   +7 more
europepmc   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Metabolic and epigenetic interplay in HSPC specification: A balance between extrinsic and intrinsic cues. [PDF]

iScience
Kalogeraki M, Rondeau V, Abou Nader Z, Espéli M, Balabanian K.   +4 more
europepmc   +1 more source

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

Oncogene, 2016
F. Guo, F. Guo, Yingmei Wang, J. Liu, S. Mok, F. Xue, Wei Zhang   +6 more
semanticscholar   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

The role of deubiquitinase USP33 in colorectal cancer tumorigenesis and its potential as a therapeutic target predictor. [PDF]

Discov Oncol
Dai Y, Luo X, Wu H, Luo Y, Deng Z, Wu J, Zhang L, Yan J.   +7 more
europepmc   +1 more source

Directional cues from CXCR4 [PDF]

Nature Reviews Immunology, 2003
openaire   +1 more source

Dynamic T‐Cell Reprogramming Modulates the Treatment Outcome of Neoadjuvant Immunochemotherapy in Non‐Small‐Cell Lung Cancer

MedComm, Volume 7, Issue 4, April 2026.
We explored the responding mechanisms associated with pathological responsiveness to neoadjuvant immunochemotherapy. CD8+ T‐cell subsets, including effect memory T (Tem), effector T (Teff), resident memory T (Trm), as well as exhausted T cells (Tex), showed higher clonality and diversity in responders, and both novel and pre‐existing clonal expansion ...
Rui Jin, Anhao Tian, Weina Lu, Qiyuan Wang, Xiuzhen Li, Sai Zhang, Guanxin Xu, Kai Zhu, Peng Li, Jianan Li, Wei Chen, Weiwei Yin, Wen Li, Yang Xia   +13 more
wiley   +1 more source