Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
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Does the Chemotherapy Protocol Affect CXCL12/CXCR4 Axes in Acute Myeloid Leukemia Patients with Monocytic Differentiation? [PDF]
Middle East Journal of Cancer, 2022 Background: The CXCR4 receptor along with CXCL12 is believed to have an effect on the onset, progression, migration, and treatment complications and improve acute myeloid leukemia (AML) treatment outcomes.
Bahar Yazdani +4 more
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Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]
, 2002 Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Cannon, C.A., Hosie, M.J., Willett, B.J.
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A Theoretical Mechanism for the Action of SONG-Modulated Laser Light on Human Very Small Embryonic-Like (hVSEL) Stem Cells in Platelet Rich Plasma (PRP) [PDF]
CellR4, 2021 It has previously been shown that human very small embryonic-like (hVSEL) stem cell proliferation occurs rapidly when hVSEL stem cells in platelet rich plasma (PRP) are exposed to Strachan Ovokaitys Node Generator (SONG)-modulated laser light.
J. Brindley, P. Hollands, T. Ovokaitys
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Essential Role of Lyn in Fibrosis. [PDF]
, 2016 Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Birtolo, Chiara +10 more
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Pretreatment with licochalcone a enhances therapeutic activity of rat bone marrow mesenchymal stem cells in animal models of colitis [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Colitis has a high prevalence rate, limited treatment options, and needs to be solved urgently. Application of Licochacone A (LA) or rBMMSCs alone in the treatment of colitis has a certain but limited effect.
Meng Chen +3 more
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome.
Busillo, John M., Benovic, Jeffrey L.
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Cells, 2019 Stromal cell-derived factor 1 (SDF-1) and its main receptor, CXC chemokine receptor 4 (CXCR4), play a critical role in endothelial cell function regulation during cardiogenesis, angiogenesis, and reendothelialization after injury. The expression of CXCR4
Jong-Ik Heo +6 more
doaj +1 more source
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]
, 2016 The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela +10 more
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CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry
Biochemical Pharmacology, 2018 The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target. Drug side effects and poor pharmacokinetic properties have been major hurdles that have prevented the implementation
Van Hout, Anneleen +17 more
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