Results 41 to 50 of about 157,119 (339)
Targeting CXCR4 in AML and ALL
Frontiers in Oncology, 2020 The interaction of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) blasts with the bone marrow microenvironment regulates self-renewal, growth signaling, as well as chemotherapy resistance.
Daniel Cancilla, M. Rettig, J. Dipersio
semanticscholar +1 more source
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]
, 2016 The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela +10 more
core +9 more sources
Does the Chemotherapy Protocol Affect CXCL12/CXCR4 Axes in Acute Myeloid Leukemia Patients with Monocytic Differentiation? [PDF]
Middle East Journal of Cancer, 2022 Background: The CXCR4 receptor along with CXCL12 is believed to have an effect on the onset, progression, migration, and treatment complications and improve acute myeloid leukemia (AML) treatment outcomes.
Bahar Yazdani +4 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome.
Busillo, John M., Benovic, Jeffrey L.
openaire +2 more sources
Theranostics, 2020 Rational: Increasing evidence indicates that the physical environment is a critical mediator of tumor behavior. Hepatocellular carcinoma (HCC) develops in an altered biomechanical environment, and increased matrix stiffness is a strong predictor of HCC ...
N. Yang +11 more
semanticscholar +1 more source
A Theoretical Mechanism for the Action of SONG-Modulated Laser Light on Human Very Small Embryonic-Like (hVSEL) Stem Cells in Platelet Rich Plasma (PRP) [PDF]
CellR4, 2021 It has previously been shown that human very small embryonic-like (hVSEL) stem cell proliferation occurs rapidly when hVSEL stem cells in platelet rich plasma (PRP) are exposed to Strachan Ovokaitys Node Generator (SONG)-modulated laser light.
J. Brindley, P. Hollands, T. Ovokaitys
doaj +1 more source
CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]
, 2016 BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus +5 more
core +1 more source
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry
Biochemical Pharmacology, 2018 The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target. Drug side effects and poor pharmacokinetic properties have been major hurdles that have prevented the implementation
Van Hout, Anneleen +17 more
openaire +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Although immune checkpoint blockade (ICB) along with nab-paclitaxel has increased progression-free survival in triple-negative breast cancer patients, a large fraction of metastatic breast cancer (mBC) patients do not benefit from ICBs.
Ivy X. Chen +9 more
semanticscholar +1 more source
European Heart Journal, 2020 AIMS Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy.
A. Hess +11 more
semanticscholar +1 more source