Results 111 to 120 of about 10,590 (201)
PLoS ONE, 2018 The CXCR4/CXCL12 axis has been extensively associated with different types of cancer correlating with higher aggressiveness and metastasis. In diffuse large B-cell lymphoma (DLBCL), the expression of the chemokine receptor CXCR4 is involved in the ...
María José Moreno +14 more
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CXCR4/CXCR7 molecular involvement in neuronal and neural progenitor migration: Focus in CNS repair [PDF]
, 2016 © 2014 Wiley Periodicals, Inc.In the adult brain, neural progenitor cells (NPCs) reside in the subventricular zone (SVZ) of the lateral ventricles, the dentate gyrus and the olfactory bulb.
Bellver-Landete, V. +3 more
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Genetic Engineering Methods in Primary T Cells
Advanced Therapeutics, Volume 8, Issue 9, September 2025.Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley +1 more source
Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross-sectional study [PDF]
, 2013 INTRODUCTION: IL-10--producing B cells, Foxp3-expressing T cells (Tregs) and the IDO-expressing dendritic cells (pDC) are able to modulate inflammatory processes, to induce immunological tolerance and, in turn, to inhibit the pathogenesis of autoimmune ...
Gabriela Hernández-Molina +5 more
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MedComm, Volume 6, Issue 9, September 2025.In this study, we explore a novel and efficient preconditioning method that induced EPCs‐like cells from hUVECs. TGF‐β inhibitors–treated hUVECs demonstrated significantly enhanced cell activity and tube‐forming ability under nutrient‐deficient and high‐glucose‐containing diabetic wound simulation conditions.
Dongsheng Su +12 more
wiley +1 more source
Reaction–Diffusion Finite Element Model of Lateral Line Primordium Migration to Explore Cell Leadership [PDF]
, 2014 Collective cell migration plays a fundamental role in many biological phenomena such as immune response, embryogenesis and tumorigenesis. In the present work, we propose a reaction–diffusion finite element model of the lateral line primordium migration ...
ALLENA, Rachele, MAINI, Philip
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GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger
British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng +3 more
wiley +1 more source
Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma
Frontiers in Endocrinology, 2020 Chemokine receptors have a negative impact on tumor progression in several human cancers and have therefore been of interest for molecular imaging and targeted therapy. However, their clinical and prognostic significance in adrenocortical carcinoma (ACC)
Irina Chifu +17 more
doaj +1 more source
Gene expression profiling of Ewing sarcoma tumours reveals the prognostic importance of tumour–stromal interactions: a report from the Children's Oncology Group [PDF]
, 2015 Relapse of Ewing sarcoma (ES) can occur months or years after initial remission, and salvage therapy for relapsed disease is usually ineffective. Thus, there is great need to develop biomarkers that can predict which patients are at risk for relapse so ...
Abdel-Wahab +51 more
core +1 more source
CXCR7 Transactives and Triggers Signaling through EGFR [PDF]
Journal of Neoplasm, 2016 Over expression of chemokine receptors such as CXCR7 is a common hallmark of various cancers. Recent evidence suggests that CXCR7 interacts with the epidermal growth factor receptor (EGFR) to activate downstream mitogenic signaling and proliferation in tumour cells. Few current therapies directly target CXCR7; however, targeting the interaction between
openaire +1 more source