Results 71 to 80 of about 10,590 (201)

CXCR7-mediated progression of osteosarcoma in the lungs [PDF]

British Journal of Cancer, 2013
Osteosarcoma (OS) is the most frequent primary malignant bone tumour in children and adolescents with a high propensity for lung metastasis. Chemokines and chemokine receptors have been described to have an important role in many malignancies including OS.
Goguet-Surmenian, E, Richard-Fiardo, P, Guillemot, E, Benchetrit, M, Gomez-Brouchet, A, Buzzo, P, Karimdjee-Soilihi, B, Alemanno, P, Michiels, J-F, Schmid-Alliana, A, Schmid-Antomarchi, H   +10 more
openaire   +2 more sources

Exosomes in Hypertrophic Scars and Keloids: Mechanisms and Therapeutic Potentials—A Narrative Review

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Hypertrophic scars and keloids, types of pathological scars, arise from dysregulated wound healing, marked by abnormal fibroblast activation and excessive extracellular matrix (ECM) deposition. Current treatments have high recurrence rates and side effects, necessitating targeted therapies. Exosomes, extracellular vesicles mediating
Mengke Wu, Jianfeng Zhang, Na Xiong, Yixiao Ma, Lingling Yong, Huaxu Liu, Qin Guo   +6 more
wiley   +1 more source

CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells

Stem Cell Research & Therapy, 2018
CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown.
Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte, Sara Teresinha Olalla Saad   +3 more
doaj   +1 more source

Niche inheritance: a cooperative pathway to enhance cancer cell fitness though ecosystem engineering [PDF]

, 2014
Cancer cells can be described as an invasive species that is able to establish itself in a new environment. The concept of niche construction can be utilized to describe the process by which cancer cells terraform their environment, thereby engineering ...
Barar J, Elton CS, Faraji F, Fidler IJ, Folkman J, Gatenby RA, Healy M, Hutchinson GE, Odling‐Smee FJ, Odling‐Smee FJ, Paget S, Pienta KJ, Weiss L, Wey JS   +13 more
core   +2 more sources

Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence supporting bevacizumab in ovarian cancer and predictive biomarkers: highlighting opportunities to improve patient selection and advance personalised treatment strategies. Abstract Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC),
Maria Rosaria Lamia, Erica Perri, Gustavo Baldassarre, Sandro Pignata, Chiara D'Alessio, Davide Limongello, Francesca Basso‐Valentina   +6 more
wiley   +1 more source

Tumor angiogenic switch determines sustained proliferative malignant transformation in tumorigenesis and overlaps with para-inflammatory phenomena [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core  

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells [PDF]

, 2014
Background:Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. CEC measured in patients with advanced cancer are thought not only to derive from damaged normal vasculature (n-CEC ...
A Ouhtit, AI Chapoval, AW Griffioen, B Croix St, C Verhoef, D J Grunhagen, D Lemke, DM McDonald, F Bertolini, F Dignat-George, GN Naumov, HR Lijnen, I Yamato, J Hagendoorn, J Kraan, J Kraan, J Kraan, J W Gratama, JA Nagy, JL Rowand, K Broll, K Hida, KH Plate, L Zimmerlin, M Crisan, MH Strijbos, N Maishi, P Carmeliet, P Steinberger, P van den Broek, PK Goon, PL Crispen, R Minhajat, R Wurth, S Seaman, S Sleijfer, SE Duff, TJ Roth, W Taal, X Qin, X Zang, Y Sun, YQ Xiong   +42 more
core   +4 more sources

Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7 [PDF]

Biochemical Pharmacology, 2013
The chemokine CXCL12 and its shared seven-transmembrane receptors CXCR4 and CXCR7 regulate diseases including cancer, atherosclerosis, autoimmunity, and HIV infection, making these molecules promising drug targets. These molecules also control key processes in normal development and physiology, suggesting the need to selectively modulate CXCR4 and/or ...
Anna, Ehrlich, Paramita, Ray, Kathryn E, Luker, Elias J, Lolis, Gary D, Luker   +4 more
openaire   +2 more sources

CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells

Heliyon, 2018
Chemokine receptors CCR5 and CXCR4 are considered the main coreceptors for initial HIV infection, replication and transmission, and subsequent AIDS progression.
Thomas D'huys, Sandra Claes, Tom Van Loy, Dominique Schols   +3 more
doaj   +1 more source

Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]

, 2013
Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y, Bailey, Gregory R, Jordon, Sian R D, Reeves, Philip J, Reynolds, Christopher A, Taddese, Bruck, Upton, Graham J G   +6 more
core   +1 more source