Results 21 to 30 of about 157,149 (239)

Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor

Frontiers in Molecular Biosciences, 2022
The ubiquitin-proteasome system is an essential regulator of many cellular processes including controlling protein homeostasis. The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints ...
Dharjath S. Hameed, Huib Ovaa, Gerbrand J. van der Heden van Noort, Aysegul Sapmaz   +3 more
doaj   +1 more source

Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

Beilstein Journal of Organic Chemistry, 2018
The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
doaj   +1 more source

Sweetening Cyclic Peptide Libraries [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources

Cyclic Peptides for Drug Development

Angewandte Chemie International Edition, 2023
AbstractCyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady ...
Ji, Xinjian, Nielsen, Alexander L., Heinis, Christian   +2 more
openaire   +2 more sources

Binding Interactions of Peptide Aptamers

Molecules, 2020
Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops located
Roger R. C. New, Tam T. T. Bui, Michal Bogus   +2 more
doaj   +1 more source

Evidence for a novel mechanism of antimicrobial action of a cyclic R-,W-rich hexapeptide. [PDF]

PLoS ONE, 2015
The development of antimicrobial peptides as new class of antibiotic agents requires structural characterisation and understanding of their diverse mechanisms of action. As the cyclic hexapeptide cWFW (cyclo(RRRWFW)) does not exert its rapid cell killing
Kathi Scheinpflug, Oxana Krylova, Heike Nikolenko, Charley Thurm, Margitta Dathe   +4 more
doaj   +1 more source

Discovery and Characteristics of a Novel Antitumor Cyclopeptide Derived from Shark

Bioengineering, 2023
Peptides pose a challenge in drug development due to their short half-lives in vivo. In this study, we conducted in vitro degradation experiments on SAIF, which is a shark-derived peptide that we previously studied.
Fu Li, Minghua Lei, Junye Xie, Shujun Guo, Weicai Li, Xiujuan Ren, Teng Wang, Songxiong Lin, Qiuling Xie, Xiaojia Chen   +9 more
doaj   +1 more source

Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides

Pharmaceutics, 2019
Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain.
Kavisha R. Ulapane, Brian M. Kopec, Teruna J. Siahaan   +2 more
doaj   +1 more source

A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

Beilstein Journal of Organic Chemistry, 2012
The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach.
James R. Cochrane, Dong Hee Yoon, Christopher S. P. McErlean, Katrina A. Jolliffe   +3 more
doaj   +1 more source

Methionine epimerization in cyclic peptides

RSC Advances, 2021
One step regioselective methionine epimerization in cyclic peptides followed by selective functionalization leads to chemical novelty.
Pramodkumar D. Jadhav, Jianheng Shen, Peta-Gaye Burnett, Jian Yang, Ramaswami Sammynaiken, Martin J. T. Reaney   +5 more
openaire   +3 more sources