Results 1 to 10 of about 424,248 (339)

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]

, 2010
The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire, Fan, Ming, Li, Jian Jian, Nantajit, Danupon, Reed, John C, Wen, Yunfei   +5 more
core   +19 more sources

Novel CRK-Cyclin Complex Controls Spindle Assembly Checkpoint in Toxoplasma Endodyogeny

mBio, 2022
Opportunistic parasites of the Apicomplexa phylum use a variety of division modes built on two types of cell cycles that incorporate two distinctive mechanisms of mitosis: uncoupled from and coupled to parasite budding.
Lauren M. Hawkins, Anatoli V. Naumov, Mrinalini Batra, Changqi Wang, Dale Chaput, Elena S. Suvorova   +5 more
doaj   +1 more source

EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of Echinococcus multilocularis germinative cells via the EGFR-ERK pathway

Frontiers in Microbiology, 2022
The larval stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans.
Chonglv Feng, Chonglv Feng, Zhe Cheng, Zhe Cheng, Zhijian Xu, Zhijian Xu, Ye Tian, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Damin Luo, Yanhai Wang, Yanhai Wang   +13 more
doaj   +1 more source

Mammaglobin 1 mediates progression of trastuzumab‐resistant breast cancer cells through regulation of cyclins and NF‐κB

FEBS Open Bio, 2022
Overexpression of human epidermal growth factor receptor 2 (HER2) in various cancers is correlated with poor patient survival. Trastuzumab, a recombinant humanized monoclonal antibody against HER2, has been considered to be a first‐line therapy for HER2 ...
Ratih Kusumastuti, Yuji Kumagai, Seiichiro Ishihara, Atsushi Enomoto, Takashi Murakami, Motoaki Yasuda, Hisashi Haga   +6 more
doaj   +1 more source

Structural insights into the functional diversity of the CDK–cyclin family [PDF]

Open Biology, 2018
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism
Daniel J. Wood, Jane A. Endicott
doaj   +1 more source

Differential expression of cyclins CCNB1 and CCNG1 is involved in the chondrocyte damage of kashin-beck disease

Frontiers in Genetics, 2022
The purpose of this study was clarify the relationship between the differential expression of cyclins CCNB1 and CCNG1 and chondrocyte damage in Kashin-Beck disease. Systematic review and high-throughput sequencing of chondrocytes derived from Kashin-Beck
Kaidiriye Setiwalidi, Jialei Fu, He Hei, Shaniya Nuer, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Shujin Li, Chaowei Wang, Yifan Wu, Yi Gong, Minhan Hu, Ruitian Huang, Junyi Liu, Tianxiao Zhang, Yujie Ning, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang   +20 more
doaj   +1 more source

Discovery of molecular and genetic mechanisms of cell cycle regulation: 2001 Nobel laureates leland Hartwell, Timothy Hunt and Paul Nurse [PDF]

The Ukrainian Biochemical Journal, 2023
Leland Hartwell, Paul Nurse and Timothy Hunt in 2001 were awarded the Nobel Prize for their discovery of molecular and genetic mechanisms of the cell cycle.
O. P. Matyshevska, V. M. Danilova, M. V. Grigorieva, S. V. Komisarenko   +3 more
doaj   +1 more source

p27^Kip1, an Intrinsically Unstructured Protein with Scaffold Properties

Cells, 2021
The Cyclin-dependent kinase (CDK) regulator p27Kip1 is a gatekeeper of G1/S transition. It also regulates G2/M progression and cytokinesis completion, via CDK-dependent or -independent mechanisms.
Debora Bencivenga, Emanuela Stampone, Domenico Roberti, Fulvio Della Ragione, Adriana Borriello   +4 more
doaj   +1 more source

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

Cell Reports, 2021
Summary: HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear.
Qingqing Chai, Sunan Li, Morgan K. Collins, Rongrong Li, Iqbal Ahmad, Silas F. Johnson, Dylan A. Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F. Hultquist, B. Matija Peterlin, Yong-Hui Zheng   +13 more
doaj   +1 more source

Effects of Icodextrin Solution (Adept^®) on Ovarian Cancer Cell Proliferation in an In Vitro Model

Medicina, 2022
Background and objective: Anti-adhesion barriers are currently used during ovarian cancer surgery to decrease adhesion-related morbidity. Adept® (4% icodextrin) solution, a liquid anti-adhesion material, has been widely used during gynecologic surgeries,
Wen-Hsin Chen, Hao Lin, Hung-Chun Fu, Chen-Hsuan Wu, Ching-Chou Tsai, Yu-Che Ou   +5 more
doaj   +1 more source