Results 1 to 10 of about 230,940 (319)

Novel CRK-Cyclin Complex Controls Spindle Assembly Checkpoint in Toxoplasma Endodyogeny

mBio, 2022
Opportunistic parasites of the Apicomplexa phylum use a variety of division modes built on two types of cell cycles that incorporate two distinctive mechanisms of mitosis: uncoupled from and coupled to parasite budding.
Lauren M. Hawkins, Anatoli V. Naumov, Mrinalini Batra, Changqi Wang, Dale Chaput, Elena S. Suvorova   +5 more
doaj   +1 more source

EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of Echinococcus multilocularis germinative cells via the EGFR-ERK pathway

Frontiers in Microbiology, 2022
The larval stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans.
Chonglv Feng, Chonglv Feng, Zhe Cheng, Zhe Cheng, Zhijian Xu, Zhijian Xu, Ye Tian, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Damin Luo, Yanhai Wang, Yanhai Wang   +13 more
doaj   +1 more source

Differential expression of cyclins CCNB1 and CCNG1 is involved in the chondrocyte damage of kashin-beck disease

Frontiers in Genetics, 2022
The purpose of this study was clarify the relationship between the differential expression of cyclins CCNB1 and CCNG1 and chondrocyte damage in Kashin-Beck disease. Systematic review and high-throughput sequencing of chondrocytes derived from Kashin-Beck
Kaidiriye Setiwalidi, Jialei Fu, He Hei, Shaniya Nuer, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Shujin Li, Chaowei Wang, Yifan Wu, Yi Gong, Minhan Hu, Ruitian Huang, Junyi Liu, Tianxiao Zhang, Yujie Ning, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang   +20 more
doaj   +1 more source

Mammaglobin 1 mediates progression of trastuzumab‐resistant breast cancer cells through regulation of cyclins and NF‐κB

FEBS Open Bio, 2022
Overexpression of human epidermal growth factor receptor 2 (HER2) in various cancers is correlated with poor patient survival. Trastuzumab, a recombinant humanized monoclonal antibody against HER2, has been considered to be a first‐line therapy for HER2 ...
Ratih Kusumastuti, Yuji Kumagai, Seiichiro Ishihara, Atsushi Enomoto, Takashi Murakami, Motoaki Yasuda, Hisashi Haga   +6 more
doaj   +1 more source

Structural insights into the functional diversity of the CDK–cyclin family [PDF]

Open Biology, 2018
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism
Daniel J. Wood, Jane A. Endicott
doaj   +1 more source

CDK control pathways integrate cell size and ploidy information to control cell division

eLife, 2021
Maintenance of cell size homeostasis is a property that is conserved throughout eukaryotes. Cell size homeostasis is brought about by the co-ordination of cell division with cell growth and requires restriction of smaller cells from undergoing mitosis ...
James Oliver Patterson, Souradeep Basu, Paul Rees, Paul Nurse   +3 more
doaj   +1 more source

The double dealing of cyclin D1 [PDF]

Cell Cycle, Taylor & Francis, 2010, pp.1-16, 2020
The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
arxiv   +1 more source

Effects of Icodextrin Solution (Adept^®) on Ovarian Cancer Cell Proliferation in an In Vitro Model

Medicina, 2022
Background and objective: Anti-adhesion barriers are currently used during ovarian cancer surgery to decrease adhesion-related morbidity. Adept® (4% icodextrin) solution, a liquid anti-adhesion material, has been widely used during gynecologic surgeries,
Wen-Hsin Chen, Hao Lin, Hung-Chun Fu, Chen-Hsuan Wu, Ching-Chou Tsai, Yu-Che Ou   +5 more
doaj   +1 more source

A Journey through Time on the Discovery of Cell Cycle Regulation

Cells, 2022
All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular).
Rustem Uzbekov, Claude Prigent
doaj   +1 more source

The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells

Mycobiology, 2020
Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent prostate cancer cell line ...
Cheng-Yen Chiang, Kai-Di Hsu, Yen-Yi Lin, Chang-Wei Hsieh, Jui-Ming Liu, Tze-Ying Lu, Kuan-Chen Cheng   +6 more
doaj   +1 more source