Results 11 to 20 of about 230,940 (319)
Cell, 2008 It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
Peter K. Jackson, Peter K. Jackson
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Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction [PDF]
The EMBO Journal, 2000 The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica +3 more
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Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas [PDF]
Archives of Pathology & Laboratory Medicine, 2000 AbstractBackground.—Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the grades of malignancy.
Lee-Cyn Ang +4 more
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Cyclin C: The Story of a Non-Cycling Cyclin [PDF]
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels.
Jan Ježek +8 more
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Cyclin K and cyclin D1b are oncogenic in myeloma cells [PDF]
Molecular Cancer, 2010 AbstractBackgroundAberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL).CCND1gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b.
Marsaud, Véronique +8 more
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How the Cyclin Became a Cyclin [PDF]
Cell, 1999 As is readily apparent, proteolysis plays a tremendously important and varied role in cell cycle regulation. While the SCF and APC are key regulators, other proteolytic systems may also contribute to cell cycle control. A well-documented case is the stabilization of p53 in response to DNA damage.
J. Wade Harper +4 more
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Cells, 2023 Head and neck cancer (HNC) therapy is limited; therefore, new solutions are increasingly being sought among flavonoids, which exhibit numerous biological properties, including potential anticancer activity.
Robert Kubina +5 more
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Discovery of molecular and genetic mechanisms of cell cycle regulation: 2001 Nobel laureates leland Hartwell, Timothy Hunt and Paul Nurse [PDF]
The Ukrainian Biochemical Journal, 2023 Leland Hartwell, Paul Nurse and Timothy Hunt in 2001 were awarded the Nobel Prize for their discovery of molecular and genetic mechanisms of the cell cycle.
O. P. Matyshevska +3 more
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p27Kip1, an Intrinsically Unstructured Protein with Scaffold Properties
Cells, 2021 The Cyclin-dependent kinase (CDK) regulator p27Kip1 is a gatekeeper of G1/S transition. It also regulates G2/M progression and cytokinesis completion, via CDK-dependent or -independent mechanisms.
Debora Bencivenga +4 more
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Open Biology, 2022 Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address.
Martina Barbiero +5 more
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