Results 11 to 20 of about 483,027 (406)
Cyclin-dependent kinases [PDF]
Genome Biology, 2014 Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity.
Marcos Malumbres
semanticscholar +4 more sources
Living with or without cyclins and cyclin-dependent kinases. [PDF]
Genes & Development, 2004 Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins.
C. Sherr, James M. Roberts
semanticscholar +3 more sources
Bifurcation in cell cycle dynamics regulated by p53 [PDF]
arXiv, 2014 We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases.
Alam, Md. Jahoor +3 more
arxiv +4 more sources
Cell, 2008 It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
Peter K. Jackson, Peter K. Jackson
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Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction [PDF]
The EMBO Journal, 2000 The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica +3 more
openaire +5 more sources
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Nature, 2020 Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid ...
Mikołaj Słabicki +23 more
semanticscholar +1 more source
Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas [PDF]
Archives of Pathology & Laboratory Medicine, 2000 AbstractBackground.—Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the grades of malignancy.
Lee-Cyn Ang +4 more
openaire +2 more sources
Cyclin C: The Story of a Non-Cycling Cyclin [PDF]
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels.
Jan Ježek +8 more
openaire +5 more sources
Human Cyclin E, a Nuclear Protein Essential for the G1-to-S Phase Transition [PDF]
Molecular and Cellular Biology, 1995 Motoaki Ohtsubo +4 more
openalex +2 more sources
Effects of Icodextrin Solution (Adept®) on Ovarian Cancer Cell Proliferation in an In Vitro Model
Medicina, 2022 Background and objective: Anti-adhesion barriers are currently used during ovarian cancer surgery to decrease adhesion-related morbidity. Adept® (4% icodextrin) solution, a liquid anti-adhesion material, has been widely used during gynecologic surgeries,
Wen-Hsin Chen +5 more
doaj +1 more source