Results 21 to 30 of about 391,733 (291)

Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy

Open Biology, 2022
Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address.
Martina Barbiero, Luca Cirillo, Sapthaswaran Veerapathiran, Catherine Coates, Camilla Ruffilli, Jonathon Pines   +5 more
doaj   +1 more source

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

CDK control pathways integrate cell size and ploidy information to control cell division

eLife, 2021
Maintenance of cell size homeostasis is a property that is conserved throughout eukaryotes. Cell size homeostasis is brought about by the co-ordination of cell division with cell growth and requires restriction of smaller cells from undergoing mitosis ...
James Oliver Patterson, Souradeep Basu, Paul Rees, Paul Nurse   +3 more
doaj   +1 more source

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis [PDF]

, 2015
Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics.
Addya, Sankar, Arnold, Andrew, Cardiff, Robert D, Casimiro, Mathew C, Crosariol, Marco, Dampier, William, Di Sante, Gabriele, Ertel, Adam, FORTINA, PAOLO, Knudsen, Erik S, Li, Zhiping, Lisanti, Michael P, Loro, Emanuele, Papanikolaou, Alexandros, Pestell, Richard G., Saria, Elizabeth A, Tozeren, Aydin, Wang, Chenguang, Yu, Zuoren   +18 more
core   +1 more source

Isolation and characterization of cold inducible genes in carrot by suppression subtractive hybridization

Biologia Plantarum, 2013
Daucus carota is cultivated widely but grows best in cool climates. Suppression subtractive hybridization (SSH) is a PCR based method used to selectively amplify differentially expressed cDNAs and simultaneously suppress non-target cDNA.
S. R. Kumar, S. Anandhan, S. Dhivya, A. Zakwan, R. Sathishkumar   +4 more
doaj   +1 more source

Modification of Transfer RNA Levels Affects Cyclin Aggregation and the Correct Duplication of Yeast Cells

Frontiers in Microbiology, 2021
Codon usage bias (the preferential use of certain synonymous codons (optimal) over others is found at the organism level (intergenomic) within specific genomes (intragenomic) and even in certain genes.
Loreto Arias, Fabián Martínez, Daniela González, Rodrigo Flores-Ríos, Assaf Katz, Mario Tello, Sandra Moreira, Omar Orellana   +7 more
doaj   +1 more source

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources

Direct repression of cyclin d1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition [PDF]

, 2007
Zinc finger transcription factors of the Snail/Slug and ZEB-1/SIP1 families control epithelial-mesenchymal transitions in development in cancer. Here, we studied SIP1-regulated mesenchymal conversion of epidermoid A431 cells.
Jakob Mejlvang, Marina Kriajevska, Cindy Vandewalle, Tatyana Chernova, A. Emre Sayan, Geert Berx, J. Kilian Mellon, Eugene Tulchinsky, Ben Margolis, Aigner K., Andersen H., Batlle E., Berx G., Blanco M. J., Bolos V., Brockbank E. C., Burstyn-Cohen T., Cano A., Carver E., Christofori G., Comijn J., De Craene B., De Craene B., Dohadwala M., Eger A., Elloul S., Franci C., Furusawa T., Guilford P., Imamichi Y., Imai T., Jiang R., Jorda M., Krishnamachary B., Knudsen K. E., Lin S., Lochter A., Maeda G., Malumbres M., McGarry L., Mejlvang J., Moreno-Bueno G., Murray S., Ohkubo T., Patrone G., Peinado H., Perez-Moreno M. A., Postigo A., Remacle J., Rosivatz E., Shy Y., Spoelstra N., Sugimachi K., Taki M., Thiery J. P., Thiery J. P., Turner F., van de Putte T., van Grunsven L. A., van Grunsven L. A., Vandewalle C., Vega S., Walker J. L., Walker J. L., Zhou B. P.   +64 more
core   +2 more sources

Ectopic Expression of Poplar PsnCYCD1;1 Reduces Cell Size and Regulates Flower Organ Development in Nicotiana tabacum

Frontiers in Plant Science, 2022
The D-type cyclin (CYCD) gene, as the rate-limiting enzyme in the G1 phase of cell cycle, plays a vital role in the process of plant growth and development. Early studies on plant cyclin mostly focused on herbs, such as Arabidopsis thaliana.
Zhongnan Zhao, Tangchun Zheng, Tangchun Zheng, Lijuan Dai, Yi Liu, Shuang Li, Guanzheng Qu   +6 more
doaj   +1 more source

eIF4A inhibitors suppress cell-cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer [PDF]

, 2019
CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including KRAS-mutant non-small cell lung cancer (NSCLC).
Cencic, Regina, Foulkes, William D., Fu, Zheng, Guiot, Marie-Christine, Huang, Sidong, Kong, Tim, Monast, Anie, Park, Morag, Pelletier, Jerry, Pilon, Virginie, Porco, John A., Sangwan, Veena, Xue, Yibo, Zhu, Xianbing   +13 more
core   +1 more source