Results 21 to 30 of about 483,027 (406)
Cyclin K and cyclin D1b are oncogenic in myeloma cells [PDF]
Molecular Cancer, 2010 AbstractBackgroundAberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL).CCND1gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b.
Marsaud, Véronique +8 more
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A Journey through Time on the Discovery of Cell Cycle Regulation
Cells, 2022 All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular).
Rustem Uzbekov, Claude Prigent
doaj +1 more source
The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells
Mycobiology, 2020 Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent prostate cancer cell line ...
Cheng-Yen Chiang +6 more
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Cells, 2023 Head and neck cancer (HNC) therapy is limited; therefore, new solutions are increasingly being sought among flavonoids, which exhibit numerous biological properties, including potential anticancer activity.
Robert Kubina +5 more
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Discovery of molecular and genetic mechanisms of cell cycle regulation: 2001 Nobel laureates leland Hartwell, Timothy Hunt and Paul Nurse [PDF]
The Ukrainian Biochemical Journal, 2023 Leland Hartwell, Paul Nurse and Timothy Hunt in 2001 were awarded the Nobel Prize for their discovery of molecular and genetic mechanisms of the cell cycle.
O. P. Matyshevska +3 more
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How the Cyclin Became a Cyclin [PDF]
Cell, 1999 As is readily apparent, proteolysis plays a tremendously important and varied role in cell cycle regulation. While the SCF and APC are key regulators, other proteolytic systems may also contribute to cell cycle control. A well-documented case is the stabilization of p53 in response to DNA damage.
J. Wade Harper +4 more
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Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins [PDF]
, 2002 Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cell cycle in G2/M.
Fung, Tsz Kan +4 more
core +1 more source
Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire +5 more
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p27Kip1, an Intrinsically Unstructured Protein with Scaffold Properties
Cells, 2021 The Cyclin-dependent kinase (CDK) regulator p27Kip1 is a gatekeeper of G1/S transition. It also regulates G2/M progression and cytokinesis completion, via CDK-dependent or -independent mechanisms.
Debora Bencivenga +4 more
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Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development, 1995 Biologic machines need brakes, and the nature and fidelity of their operation cannot be unraveled without some prior understanding of how accelerators work. The discoveD] of mammalian G1 cyclins just 4 years ago and the identification of their associated
C. Sherr, James M. Roberts
semanticscholar +1 more source