Results 21 to 30 of about 227,102 (266)
Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
BMC Gastroenterology, 2004 Background Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer.
Mahmoud Moustafa +6 more
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Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
Frontiers in Cell and Developmental Biology, 2021 DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell
Rafaela Fagundes, Leonardo K. Teixeira
doaj +1 more source
Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2 [PDF]
Cell Cycle, 2007 The transitions of the cell cycle are regulated by the cyclin dependent protein kinases (CDKs). The cyclins activate their respective CDKs and confer substrate recognition properties. We report the structure of phospho-CDK2/cyclin B and show that cyclin B confers M phase-like properties on CDK2, the kinase that is usually associated with S phase ...
Brown, N. R. +5 more
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The cyclin D1b splice variant: an old oncogene learns new tricks
Cell Division, 2006 The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6 ...
Knudsen Karen E
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Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas
Archives of Pathology & Laboratory Medicine, 2000 AbstractBackground.—Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the grades of malignancy.
K, Allan +4 more
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médecine/sciences, 1993 La cycline A, associee a la proteine kinase p34 cdc2 , est impliquee dans la transition G2/M du cycle. Elle s'associe aussi a la proteine kinase p33 cdk2 au cours de la phase S du cycle. La cycline A participe a la formation de complexes multimeriques comprenant le facteur de transcription E2F, la proteine kinase p33 cdk2 et la proteine p107 ...
E. Lamas +7 more
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Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1
BMC Research Notes, 2011 Background The elongation phase, like other steps of transcription by RNA Polymerase II, is subject to regulation. The positive transcription elongation factor b (P-TEFb) complex allows for the transition of mRNA synthesis to the productive elongation ...
Yu Wendong +2 more
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The crystal structure of cyclin A [PDF]
Structure, 1995 Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs.
Brown NR +8 more
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Viruses, 2016 The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is ...
Mirjam Steingruber +9 more
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Cyclin-dependent kinases: a family portrait [PDF]
Nature Cell Biology, 2009 To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of ...
Marcos, Malumbres +8 more
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