Results 51 to 60 of about 1,006 (183)

Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena

Marine Drugs, 2009
Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8–10 (1–3).
Hendrik Luesch, Valerie J. Paul, Kanchan Taori, Jason C. Kwan   +3 more
doaj   +1 more source

Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus

Marine Drugs, 2014
Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds ...
Feng-Yu Du, Xiao-Ming Li, Peng Zhang, Chun-Shun Li, Bin-Gui Wang   +4 more
doaj   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Re‐Engineering Fungal Nonribosomal Peptide Synthetases by Module Dissection and Duplicated Thiolation Domains

Angewandte Chemie, Volume 136, Issue 33, August 12, 2024.
A new strategy is presented to dissect fungal nonribosomal peptide synthetases into “splitting unit” pairs (SUPs). Collaboration in SUPs is facilitated by artificial duplication of the thiolation domain and its linkers, and an optimized split site. The productivities of SUPs match or exceed those of the corresponding single‐subunit chimeras or even ...
Miaomiao Yin, Linan Xie, Kang Chen, Liwen Zhang, Qun Yue, Chen Wang, Juntian Zeng, Xiaoyang Hao, Xiaofeng Gu, István Molnár, Yuquan Xu   +10 more
wiley   +2 more sources

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Alkynyl Phenyl Selenides as Intermediates in the Metal‐Free Cyclisation of N‐Tosyl Homopropargyl Amides to γ‐Lactams

European Journal of Organic Chemistry, Volume 28, Issue 8, February 24, 2025.
This study introduces an efficient Brønsted acid‐catalyzed intramolecular hydroamination of homopropargyl N‐tosyl amides to synthesize substituted γ‐lactams via alkynyl phenyl selenide intermediates. Optimization of the flow‐based cyclization improved efficiency, saving time and resources.
Andrea Temperini, Giulia Brufani, Stefano Santoro, Luigi Vaccaro   +3 more
wiley   +1 more source

Insights into Penicillium brasilianum Secondary Metabolism and Its Biotechnological Potential

Molecules, 2017
Over the past few years Penicillium brasilianum has been isolated from many different environmental sources as soil isolates, plant endophytes and onion pathogen.
Jaqueline Moraes Bazioli, Luciana Da Silva Amaral, Taícia Pacheco Fill, Edson Rodrigues-Filho   +3 more
doaj   +1 more source

Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A [PDF]

Proceedings of the National Academy of Sciences, 2004
A total synthesis of apratoxin A was developed. Apratoxin A, isolated from Lyngbya spp. cyanobacteria, is representative of a growing class of marine cyanobacterial cyclodepsipeptides wherein discrete polypeptide and polyketide domains are merged by ester and amide or amide-derived linkages. In the apratoxins, the N
Jiehao, Chen, Craig J, Forsyth
openaire   +2 more sources

Peroral administration of beauverolides allows their transport into the peripheral blood and urine

CyTA - Journal of Food, 2020
Beauverolides are hydrophobic cyclodepsipeptides that inhibit sterol O-acyltransferases and calmodulin, thereby reducing senile plaques in Alzheimer’s disease and preventing foam cell formation in atherosclerosis.
Petr Heneberg, Alexandr Jegorov, Petr Šimek   +2 more
doaj   +1 more source

The first total synthesis of the cyclodepsipeptide pipecolidepsin A [PDF]

Nature Communications, 2013
Pipecolidepsin A is a head-to-side-chain cyclodepsipeptide isolated from the marine sponge Homophymia lamellosa. This compound shows relevant cytotoxic activity in three human tumour cell lines and has unique structural features, with an abundance of non-proteinogenic residues, including several intriguing amino acids.
Marta, Pelay-Gimeno, Yésica, García-Ramos, Maria, Jesús Martin, Jan, Spengler, José Manuel, Molina-Guijarro, Simon, Munt, Andrés M, Francesch, Carmen, Cuevas, Judit, Tulla-Puche, Fernando, Albericio   +9 more
openaire   +2 more sources