Results 31 to 40 of about 50,064 (212)
Analyses of the toxic properties of recombinant human Cyclophilin A in mice
Journal of Immunotoxicology, 2019 Cyclophilin A (CypA), an 18 kDa multi-functional protein with cis–trans isomerase activity, is both a ligand for cyclosporine A and a proinflammatory factor. CypA is also a chemoattractant for hemopoietic stem cells and progenitors of different lineages,
Anastasiya Kalinina +6 more
doaj +1 more source
BMC Genomics, 2022 Background Cyclophilin (CYP) belongs to the immunophilin family and has peptidyl-prolyl cis-trans isomerase (PPIase) activity, which catalyzes the cis-trans isomerization process of proline residues.
Zhi-Wen Qiao +4 more
doaj +1 more source
Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]
, 2017 International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu +10 more
core +4 more sources
Cyclophilin A interacts with diverse lentiviral capsids [PDF]
Retrovirology, 2006 The capsid (CA) protein of HIV-1 binds with high affinity to the host protein cyclophilin A (CypA). This binding positively affects some early stage of the viral life-cycle because prevention of binding either by drugs that occupy that active site of cyclophilin A, by mutation in HIV-1 CA, or RNAi that knocks down intracellular CypA level diminishes ...
Tsai-Yu, Lin, Emerman, Michael
openaire +4 more sources
Cyclophilin A accelerates SiO2-induced macrophage foaming
Cellular Signalling, 2023 Silicosis is a common occupational disease characterized by lung inflammation, fibrosis and pulmonary dysfunction caused by long-term inhalation of free SiO2. Cell foaming and the change of CyPA have been observed in SiO2-induced macrophages, but the specific mechanism of CyPA in SiO2-induced foam cells remains poorly understood.
Heliang, Liu +5 more
openaire +2 more sources
Hypertension in Pregnancy, 2017 Objective: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level.
Noroyono Wibowo +3 more
doaj +1 more source
Cells, 2021 Impairment of efferocytosis in apoptotic macrophages is a known determinant of the severity of atherosclerosis and the vulnerability of plaques to rupture. The precise mechanisms involved in impaired efferocytosis are unclear.
Vinitha Anandan +8 more
doaj +1 more source
When life comes to an end : lessons from microbial aging models [PDF]
, 2010 Aging of biological systems ultimately leads to death of the individual. In humans, organ failure as the result of functional impairments after stroke, cardio-vascular disease, tumor development, neurodegeneration and other diseases are certainly crucial
Osiewacz, Heinz D.
core +1 more source
Facile Synthesis of a Fluorescent Cyclosporin A Analogue To Study Cyclophilin 40 and Cyclophilin 18 Ligands [PDF]
ACS Medicinal Chemistry Letters, 2010 There are strong indications for the involvement of cyclophilin 40 in diseases caused by misregulation of steroid hormone receptors, like prostate or breast cancer. To identify novel inhibitors for this immunophilin, we developed a simplified fluorescence polarization assay based on the synthesis of a fluorescein-labeled tracer.
Gaali, S. +4 more
openaire +3 more sources
Cyclophilin B serum levels present variations across the menstrual cycle
Scientific Reports, 2023 Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia ...
Rebeca Alvariño +7 more
doaj +1 more source