Results 121 to 130 of about 45,384 (211)

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He, Mengyao Qu, Lu Yu, Lipeng He, Yixun Lu, Jin Hong, Miao Sun, Huikai Yang, Weidong Mi, Hang Guo, Yulong Ma   +10 more
wiley   +1 more source

The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice.

PLoS ONE, 2019
Hepatitis B virus (HBV) infection is a major health burden worldwide with 240 million chronically infected individuals. Nucleos(t)ide analogs and interferons are the current standards of care due to their suppression of HBV replication, but the ...
Philippe Gallay, Daren Ure, Michael Bobardt, Udayan Chatterji, James Ou, Daniel Trepanier, Robert Foster   +6 more
doaj   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

Parthanatos drives cognitive decline in repeated brain trauma: MSC-derived exosomes as a novel therapeutic strategy

Frontiers in Pharmacology
IntroductionRepetitive traumatic brain injury (RTBI) represents a cumulative neurological insult associated with progressive neurodegeneration and limited therapeutic options.
Heba Mohammed Refat M. Selim, Amira A. El-Gazar, Dalaal M. Abdallah, Hagar B. Abo-Zalam, Ghada M. Ragab, Ahmed N. Abdallah, Rabab A. El-Gazar, Sultan Alshehri, Einas M. Yousef, Rayan Ballal, Sahar N. Aljarallah, Asmaa Saleh, Nada F. Abou Chahin, Naheda S. Alsammak, Rasha A. Mandil, Hanan S. El-Abhar   +15 more
doaj   +1 more source

Propofol-Induced Mitochondrial Dysfunction Is Independent of Mitochondrial Permeability Transition

Biomedicines
Background/Objectives: In recent years, it has been suggested that sedatives may cause brain damage. One possible mechanism is interference with oxidative phosphorylation of brain mitochondria, but much remains unknown.
Aya Kawachi, Shoichiro Shibata, Eskil Elmér, Hiroyuki Uchino   +3 more
doaj   +1 more source

Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases

Journal of Immunology Research, 2015
Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL).
Yi Zhang, Jun Li, Ya-Min Zhang, Xiao-Ming Zhang, Juan Tao   +4 more
doaj   +1 more source

Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes

BMC Immunology, 2010
Background Gene expression in lipopolysaccharide (LPS)-stimulated monocytes is mainly studied by quantitative real-time reverse transcription PCR (RT-qPCR) using GAPDH (glyceraldehyde 3-phosphate dehydrogenase) or ACTB (beta-actin) as reference gene for ...
Øvstebø Reidun, Grimholt Runa M, Piehler Armin P, Berg Jens P   +3 more
doaj   +1 more source

Cyclophilin B, a molecule chaperone, promotes adipogenesis in 3T3‑L1 preadipocytes via AKT/mTOR pathway. [PDF]

Int J Mol Med, 2023
Yoon JS, Kim SS, Ha J, Kang I, Choe W.
europepmc   +1 more source

The control of viral infection by tripartite motif proteins and cyclophilin A

Retrovirology, 2007
The control of retroviral infection by antiviral factors referred to as restriction factors has become an exciting area in infectious disease research.
Towers Greg J
doaj   +1 more source