Results 51 to 60 of about 13,126 (201)

Cocrystallization and Micronization as Strategies to Optimize the Bioavailability of Naringin and Naringenin Molecules: A Comprehensive Review of In Vivo and In Vitro Pharmaceutical Applications

Crystal Research and Technology, Volume 61, Issue 7, July 2026.
Naringin and naringenin exhibit well‐recognized therapeutic potential; however, they face limitations related to solubility and bioavailability. Micronization increases surface area and enhances absorption. Notably, cocrystallization stands out as a primary strategy for particle optimization, as it refines physicochemical properties, improves ...
Emilia Rodrigues Almeida, Kanandra Taisa Bertoncello, Ketelin Zamin Kuhn, Liz Girardi Müller, J. Vladimir Oliveira   +4 more
wiley   +1 more source

Expression of aromatase CYP19 and its relationship with parameters in NSCLC

Frontiers in Bioscience, 2009
Human aromatase (CYP19) responsible for the conversion of androgens to estrogens is expressed not only in gonads and adrenals but also in many other tissues, including normal lungs and lung cancers. To investigate the involvement of CYP19 in lung cancer development, purified CYP19 protein and antibody are required.
Tsunehiro, Oyama, Norio, Kagawa, Kenji, Sugio, Hidetaka, Uramoto, Osamu, Hatano, Nobuhiro, Harada, Kazuhiro, Kaneko, Toshihiro, Kawamoto, Kosei, Yasumoto   +8 more
openaire   +2 more sources

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs. The CONTAM Panel concluded that TDBPP, DBPNG and TBNPA are considered genotoxic and carcinogenic.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
wiley   +1 more source

Targeting ParPMC Susceptibility Hubs in Prunus: eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
ParPMC interactors were screened, highlighting eEF1A proteins; co‐localization and VIGS show their role in PPV infection and sharka susceptibility. ABSTRACT Sharka, caused by Potyvirus plumpoxi (plum pox virus, PPV), is the most destructive viral disease affecting Prunus species worldwide.
Ángela Polo‐Oltra, Alba Lloret, Jesús A. Sánchez‐Navarro, Gabino Ríos, Carlos Romero, Elena Zuriaga   +5 more
wiley   +1 more source

Differential expression of genes in follicular cells of swines Expressão diferencial de genes em células foliculares de suínos

Revista Brasileira de Zootecnia, 2010
The main purpose of the present study was to identify for candidate genes related to ovulation in swines. To do so, it was investigated in ovarian follicular cells through quantitative real-time PCR the differential expression of the following genes ...
Cristiana Libardi Miranda-Furtado, Priscila Vendramini Silva, Marta Fonseca Martins Guimarães, Nicola Vergara Lopes Serão, José Domingos Guimarães, Simone Eliza Facioni Guimarães   +5 more
doaj   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, Volume 255, Issue 3, Page 340-361, March 2026.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Variable Cre Recombination Efficiency in Placentas of Cyp19-Cre ROSA mT/mG Transgenic Mice

, 2023
The aromatase-Cre recombinase (Cyp19-Cre) transgenic mouse model has been extensively used for placenta-specific gene inactivation. In a pilot study, we observed unexpected phenotypes using this mouse strain, which prompted an extensive characterization ...
Nayak, Neha, Nayak, Nihar R, Mor, Gil, Anamthathmakula, Prashanth, Dhal, Sabita, Shallie, Philemon D, Vivian, Jay L, Soares, Michael J   +7 more
core  

Phloem Proteomics to Identify Small Open Reading Frame (sORF)‐encoded Peptides With a Putative Role in the Control of Flowering Time in Arabidopsis

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phloem sap proteomic studies have previously revealed that phloem sap composition varies during development and upon floral induction. Specific proteins, lipids, messenger RNAs (mRNAs), and peptides have been shown to accumulate at different developmental stages.
Irene Moreno‐Sanguino, Lucía Argente Collás, Göran Samuelsson, Gunnar Wingsle, Reyes Benlloch   +4 more
wiley   +1 more source

Analysis of aromatase (CYP19) gene in Iranian women with endometriosis [PDF]

, 2013
Endometriosis is a chronic, inflammatory, estrogen dependent disease that affects up to 10% of all women of fertile age. It is characterized by the presence and proliferation of functional endometrial glands and stroma outside the uterine cavity. The aim
Salehi, Zivar, Sadri, Saiedeh, Saber, Hajar   +2 more
core  

Regulation by 3,5,3ʹ-tri-iodothyronine and FSH of cytochrome P450 family 19 (CYP19) expression in mouse granulosa cells

, 2018
Cytochrome P450 family 19 (CYP19) plays an important role in follicular development, which is regulated by FSH. Although 3,5,3′-tri-iodothyronine (T3) combines with FSH to induce preantral follicle growth and granulosa cell development, the mechanism ...
Yanzhou Yang, Juan Liu, Yingying Han, Dai Heng, Cheng Zhang, Ye Tian, Xusong Hu, Wenbo Liu, Xuechun Weng, Kaili Xu   +9 more
core   +1 more source