Results 121 to 130 of about 47,525 (299)

Systematic review: Safety and efficacy of atomoxetine in children and adolescents with autism spectrum disorder

JCPP Advances, EarlyView.
This systematic review aimed to assess the current evidence on the efficacy and safety of Atomoxetine in common clinical symptoms of autism spectrum disorder (ASD) for children and adolescents. With limited studies available, there is a need for more high‐power studies for the use of Atomoxetine in children and adolescents with autism spectrum disorder.
Nihit Gupta, Daniel Boyes, Hunter Hanlon‐Taylor, Mayank Gupta   +3 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION

Разработка и регистрация лекарственных средств, 2019
A sensitive method for quantification of pinoline and its metabolite in human plasma using solid phase extraction and high performance liquid chromatography with mass-spectrometry was developed.
R. K. Abdrashitov, A. E. Petukhov, V. V. Smirnov   +2 more
doaj  

Антипсихотические лекарственные средства. Риск развития экстрапирамидных нарушений и/или абстинентного синдрома у новорожденных, матери которых принимали вышеуказанные лекарственные средства в течение третьего триместра беременности [PDF]

, 2011
ЛЕКАРСТВАТРАНКВИЛИЗАТОРЫ ...
Birgisson, Björn, Kringos, Niki, Zhu, Jiqing   +2 more
core   +2 more sources

The CYP2D6 VCF Translator [PDF]

The Pharmacogenomics Journal, 2016
R Chen, J Wang, Benjamin Pullman, Yao Yang, Stuart A. Scott, Wanqiong Qiao   +5 more
openaire   +2 more sources

Peptides From Adzuki Bean and Soybean Improved Insulin‐AKT Signaling‐Related Pathways in Healthy and Insulin‐Resistant States in Human Liver Cells

Molecular Nutrition &Food Research, EarlyView.
This study investigated the antidiabetic potential of adzuki bean β‐vignin and soybean β‐conglycinin peptides in human liver cells in healthy and insulin‐resistant states. Peptide Val‐Pro was found to inhibit dipeptidyl peptidase IV and stimulate the insulin signaling pathway, suggesting the potential for developing healthier adzuki bean‐based ...
Shu Hang Kwan, Elvira Gonzalez de Mejia
wiley   +1 more source

Slow CYP2D6 metabolizer phenotype associated with death in a toddler receiving a therapeutic dose of dextromethorphan. 313 [PDF]

, 1997
Benoit Bailey, Nick Daneman, Richard Daneman, Joel M. Mayer, Gideon Koren   +4 more
openalex   +1 more source

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study

Malaria Journal, 2018
Background Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine.
Kanokpich Puaprasert, Cindy Chu, Naowarat Saralamba, Nicholas P. J. Day, Francois Nosten, Nicholas J. White, Arjen M. Dondorp, Mallika Imwong   +7 more
doaj   +1 more source

CYP2D6, NAT2 and CYP2EI genetic polymorphisms in nonagenarians [PDF]

, 1997
José A. G. Agúndez, I.J. Posada Rodriguez, Manuela Olivera, José M. Ladero, María del Mar Ballesteros García, Josep‐María Ribera, Julio Benítez   +6 more
openalex   +1 more source

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors

ChemistryOpen, EarlyView.
Novel benzimidazothiazole–thiazole hybrids are synthesized and evaluated for anticancer activity against HCT‐116 colon cancer cells. Compound 16b shows superior cytotoxicity over doxorubicin. Molecular docking confirms strong binding to 6MTU protein, and ADMET profiling indicates favorable pharmacokinetics and low toxicity.
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
wiley   +1 more source