Results 121 to 130 of about 49,282 (280)

Clinical applications of personalized medicine: a new paradigm and challenge [PDF]

, 2017
The personalized medicine is an emergent and rapidly developing method of clinical practice that uses new technologies to provide decisions in regard to the prediction, prevention, diagnosis and treatment of disease.
Borro, Marina, DI SANZO, Mariantonia, Fineschi, Vittorio, Frati, Paola, LA RUSSA, Raffaele, Santurro, Alessandro, Scopetti, Matteo, Simmaco, Maurizio   +7 more
core   +1 more source

Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 591-597, March 2026.
Radiolabeled human mass balance studies are crucial for identifying circulating metabolites and understanding drug absorption, excretion, and clearance pathways. Metabolite profiling involves quantifying all drug‐related entities, including parent drug and metabolites in plasma and excreta, using extended liquid chromatography methods coupled with ...
Filip Cuyckens, Wenying Li, Adam M. Auclair, Kenneth C. Cassidy, Cathy Cantalloube, Gary Collins, Alexander D. James, Chris Gibson, Ulrike Glaenzel, Felix Huth, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Pietro Brunetti, Hanno Schieferstein, David Wagner, Gregory S. Walker, Shuai Wang, Qin Yue, Jason Boer, Cyrus Khojasteh   +21 more
wiley   +1 more source

Pharmacogenetics and individualizing drug treatment during pregnancy [PDF]

, 2014
Pharmacogenetics as a tool to aid clinicians implement individualized pharmacotherapy is utilized in some areas of medicine. Pharmacogenetics in pregnancy is still a developing field.
Haas, David M.
core   +1 more source

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

Valbenazine induced acute parkinsonism in a patient with alcohol use disorder and central pontine myelinolysis

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Background Valbenazine is used to treat dyskinesia and is generally associated with limited side effects; however, a few cases with the adverse effect of parkinsonism are reported in the literature. In this study, we report a case of valbenazine‐induced acute parkinsonism.
Yasuhito Nagai, Miyata Mamiko, Koichi Miyakawa   +2 more
wiley   +1 more source

Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer

, 2015
Tamoxifen is the standard-of-care treatment for estrogen receptor-positive premenopausal breast cancer. We examined tamoxifen metabolism via blood metabolite concentrations and germline variations of CYP3A5, CYP2C9, CYP2C19 and CYP2D6 in 587 ...
A Ahmad, A Gaedigk, A Tfayli, B Chowbay, B Eccles, B Ganchev, B Makubate, C Davies, C McCowan, D Eccles, D Eccles, DL Hershman, DL Hershman, E Copson, E Schaeffeler, Early Breast Cancer Trialists’ Collaborative Group, EJA Bowles, EP Winer, H Brauch, H Brauch, H Brauch, H Brauch, I Zineh, J S L Lim, J Sistonen, JE Abraham, JK Coller, JM Rae, JM Rae, JSL Lim, K Dickschen, K Kiyotani, K Kiyotani, K Kiyotani, KJ Ruddy, L Madlensky, M Dowsett, M Eichelbaum, M Gnant, M Schwab, M Z Habbal, MA Province, MD Johnson, MF Barginear, MJ Ratain, MM Regan, MM Regan, MP Goetz, N K Zgheib, N S Wong, O Pagani, P Saladores, PH Saladores, PM Ravdin, PY Maximov, R C H Ng, R Dent, R McCague, Richard G. Gray, RR Love, RT Chlebowski, S Gerty, S Winter, T Mürdter, TE Mürdter, TL Lash, UM Zanger, UM Zanger, VC Jordan, VO Dezentjé, W Lorizio, W Schroth, W Schroth, W Schroth, WJ Irvin Jr, WJ Lu, Y Jin, Y S Yap, YC Lim, Z Awada, Z Desta   +80 more
core   +1 more source

Антипсихотические лекарственные средства. Риск развития экстрапирамидных нарушений и/или абстинентного синдрома у новорожденных, матери которых принимали вышеуказанные лекарственные средства в течение третьего триместра беременности [PDF]

, 2011
ЛЕКАРСТВАТРАНКВИЛИЗАТОРЫ ...
Birgisson, Björn, Kringos, Niki, Zhu, Jiqing   +2 more
core   +2 more sources

Personalized care of paediatric drug‐resistant epilepsy in Africa: A single‐centre pilot study utilizing mobile health and genetic testing

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 394-406, March 2026.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.70075 This original article is commented on by Mante on pages 307–308 of this issue. Abstract Aim To evaluate personalized care or precision medicine initiatives, including mobile health (mHealth) technology and genetic screening, in a South African paediatric epilepsy clinic ...
Ian S. Olivier, Karen Fieggen, Sandra Komarzynski, Elin H. Davies, Irene Muchada, Caitlin McIntosh, Alina Esterhuizen, Richard J. Burman, Jo M. Wilmshurst, and the University of Cape Town (UCT) Human Genetics Precision Medicine Epilepsy Group, Nicholas Loxton, Shrinav R Dawlatt, Akshay Vanmali   +12 more
wiley   +1 more source

Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia [version 3; peer review: 2 approved]

F1000Research
Background Cytochrome P450 2D6 (CYP2D6) is an important enzyme that metabolizes commonly used drugs, such as tramadol hydrochloride. Genetic polymorphisms of CYP2D6 have been shown to influence the pharmacodynamic properties of administered drugs.
Nuruliawaty Utami, Bagus Dermawan, Asrul Muhammad Fuad, Aufa Rizqia Haz, Rinal Effendi, . Desriani   +5 more
doaj   +1 more source

Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions

Pharmacogenomics and Personalized Medicine, 2021
Chiara Jeiziner,1 Céline K Stäuble,1,2 Markus L Lampert,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland ...
Jeiziner C, Stäuble CK, Lampert ML, Hersberger KE, Meyer zu Schwabedissen HE   +4 more
doaj