Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro
Pharmaceutical Biology, 2021 Context Pogostone possesses various pharmacological activities, which makes it widely used in the clinic. Its effect on the activity of cytochrome P450 enzymes (CYP450s) could guide its clinical combination.
Guiying Zhang +5 more
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Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes
Pharmaceutical Biology, 2020 Context Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine.
Mingwei Wang +4 more
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Saudi Pharmaceutical Journal, 2021 Objectives Cytochrome P450 2E1 (CYP2E1) is one of the major enzymes involved in the metabolism and detoxification of various drugs and xenobiotics. Polymorphisms in the CYP2E1 gene exhibit high inter-individual variations associated with alterations in ...
Lenah S. Binmahfouz, Amina M. Bagher
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Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients.
PLoS ONE, 2012 BackgroundThe CYP2E1 and GSTM1 genes encode metabolic enzymes that have key functions in drug modification and elimination.Methodology/principal findingsWe investigated the possible effects of CYP2E1 and GSTM1 polymorphisms in 71 leprosy patients and in ...
Pablo Pinto +6 more
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Downregulation of CYP2E1 is associated with poor prognosis and tumor progression of gliomas
Cancer Medicine, 2021 Objective To explore the role and possible regulatory mechanisms of CYP2E1 in gliomas. Methods RNA‑seq data and corresponding clinical information of glioma patients were collected from The Cancer Genome Atlas and Chinese Glioma Genome Atlas, and mRNA ...
Liguo Ye +7 more
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The Correlation of Cyp2e1 Genetic Polymorphism on Alcohol Drinking Habits in Papuan Ethnicity
Mutiara Medika, 2021 Alcohol abuse is associated with genetic factors and is influenced by certain races and ethnicities. CYP2E1, which works on the endoplasmic reticulum, produces an enzyme that plays a significant role in alcohol metabolism.
Mardhatillah Marsa +3 more
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Journal of Translational Medicine, 2022 Objective Knowledge of the role of CYP2E1 in hepatocarcinogenesis is largely based on epidemiological and animal studies, with a primary focus on the role of CYP2E1 in metabolic activation of procarcinogens. Few studies have directly assessed the effects
Lili Zhu +9 more
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Silymarin and N-acetylcysteine reduce acetaminophen-induced liver damage in rats by modulating the expression of CYP2E1 and Nrf2 genes [PDF]
Caspian Journal of Environmental SciencesWhile silymarin and N-acetylcysteine have well-established individual protective properties against acetaminophen (APAP)-induced liver injury, their synergistic effects on key genes, such as CYP2E1 and Nrf2, have not been thoroughly investigated in a ...
Salar khazeni Fard +9 more
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HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells. [PDF]
PLoS ONE, 2014 CYP2E1, one of the cytochrome P450 mixed-function oxidases located predominantly in liver, plays a key role in metabolism of xenobiotics including ethanol and procarcinogens. Recently, down-expression of CYP2E1 was found in hepatocellular carcinoma (HCC)
Hongming Liu +6 more
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In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2020 Context Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metabolized by cytochromes P450.
Shangchen Xu +5 more
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