Results 31 to 40 of about 15,252 (135)

In vitro inhibitory effects of bergenin on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2018
Context: Bergenin, isolated from the herb of Bergenia purpurascens (Hook. f. et Thoms.) Engl., has anti-inflammatory, antitussive, and wound healing activities.
Gang Dong, Yun Zhou, Xiaoli Song
doaj   +1 more source

Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury

Antioxidants, 2021
Despite existing strong evidence on oxidative markers overproduction following ischemia/reperfusion (I/R), the mechanism by which oxidative enzyme Cytochrome P450-2E1 (CYP2E1) contributes to I/R outcomes is not clear. In this study, we sought to evaluate
Jin Yu, Hong Zhu, Mark S. Kindy, Saeid Taheri   +3 more
doaj   +1 more source

In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2017
Context: Dihydromyricetin (DHM) is the most abundant and active flavonoid component isolated from Ampelopsis grossedentata (Hand-Mazz) W.T. Wang (Vitaceae) and it possesses numerous pharmacological activities. However, whether DHM affects the activity of
Lu Liu, Sen Sun, Hongbing Rui, Xiaohua Li   +3 more
doaj   +1 more source

In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2018
Context: Friedelin is a triterpenoid with several biological activities. However, the affects of Friedelin on the activity of human liver cytochrome P450 (CYP) enzymes remains unclear.
Jinlan Wei, Hongying Zhang, Qingling Zhao   +2 more
doaj   +1 more source

Next-Generation Sequencing and Bioinformatics-Based Protocol for the Full-Length CYP2E1 Gene Polymorphism Analysis

Pharmacogenomics and Personalized Medicine, 2022
Viktorija Igumnova,1,2 Agnija Kivrane,1,2 Anda Viksna,3,4 Inga Norvaisa,4 Renate Ranka1,2 1Molecular Microbiology Group, Latvian Biomedical Research and Study Centre, Riga, Latvia; 2Department of Pharmaceutical Chemistry, Riga Stradins University, Riga ...
Igumnova V, Kivrane A, Viksna A, Norvaisa I, Ranka R   +4 more
doaj  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity

Acta Pharmaceutica Sinica B, 2022
Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored.
Youbo Zhang, Tingting Yan, Tianxia Wang, Xiaoyan Liu, Keisuke Hamada, Dongxue Sun, Yizheng Sun, Yanfang Yang, Jing Wang, Shogo Takahashi, Qiong Wang, Kristopher W. Krausz, Changtao Jiang, Cen Xie, Xiuwei Yang, Frank J. Gonzalez   +15 more
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

New Molecular Mechanism Underlying Myc‐Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Canonical studies indicate that cytochrome P450 2E1 (CYP2E1) plays a critical role in the metabolism of xenobiotics and ultimately participates in tissue damage.
Feifei Guan, Xinlan Yang, Jing Li, Wei Dong, Xu Zhang, Ning Liu, Shan Gao, Jizheng Wang, Lianfeng Zhang, Dan Lu   +9 more
doaj   +1 more source