Results 51 to 60 of about 15,252 (135)

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Recombinant ADAMTS13 Ameliorates Liver Injury and Improves Hepatic Microcirculation in a Murine Acute‐on‐Chronic Liver Failure Model

Hepatology Research, EarlyView.
ABSTRACT Aim The therapeutic significance of recombinant a disintegrin‐like and metalloprotease with thrombospondin type 1 motif 13 (rADAMTS13) in acute‐on‐chronic liver failure (ACLF) remains unclear. We aimed to investigate the therapeutic effects of rADAMTS13 in a murine model of ACLF‐like liver injury.
Jun‐ichi Hanatani, Norihisa Nishimura, Kosuke Kaji, Masayoshi Takami, Hiroyuki Masuda, Hiroaki Takaya, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji   +9 more
wiley   +1 more source

Subcellular expression of CYP2E1 in HepG2 cells impacts response to free oleic and palmitic acid

Current Research in Toxicology
Aims: Cytochrome P450 2E1 (CYP2E1) is a mammalian monooxygenase expressed at high levels in the liver that metabolizes low molecular weight pollutants and drugs, as well as endogenous fatty acids and ketones.
Zaria K. Killingsworth, Kelly R. Misare, Abigail S. Ryan, Elizabeth A. Ampolini, Tsultrim T. Mendenhall, Melinda A. Engevik, Jessica H. Hartman   +6 more
doaj   +1 more source

Alcohol‐Associated Pancreatitis Confers Higher Risk of Advanced Liver Disease Than Alcohol Withdrawal Syndrome

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Alcohol‐associated liver disease frequently presents late as decompensated cirrhosis, representing a missed opportunity for intervention. Extrahepatic alcohol‐related presentations requiring acute care, such as alcohol‐associated pancreatitis and alcohol withdrawal syndrome, may identify heavy drinkers at varying risk for ...
Butros Fakhoury, Leandro Sierra, Krishan Patel, Hyundam Gu, Luis Antonio Díaz, Juan Pablo Arab   +5 more
wiley   +1 more source

Pharmacogenomics in Dentistry: From CYP‐Mediated Drug Response to Precision Prescribing in Oral Healthcare

Oral Diseases, EarlyView.
ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci   +3 more
wiley   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1368-1378, November 2026.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts

Redox Biology, 2014
Exocyclic etheno-DNA adducts are mutagenic and carcinogenic and are formed by the reaction of lipidperoxidation (LPO) products such as 4-hydoxynonenal or malondialdehyde with DNA bases.
Kirsten Linhart, Helmut Bartsch, Helmut K. Seitz   +2 more
doaj   +1 more source

High Doses of N‐Acetyl‐P‐Aminophenol Cause Acute Changes in Electroencephalographic and Electrocardiographic Activities in Wistar Rats

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT N‐acetyl‐p‐aminophenol (APAP), or acetaminophen, is the most prescribed analgesic and antipyretic, even used in association with other drugs. Because it is easily bought in drugstores, much evidence about its toxic effects is known due to high doses or continuous use, which can lead to death in cases of intoxication.
Alex Luiz Menezes da Silva, Luiz Gustavo dos Reis de Freitas, Akira Otake Hamoy, Clarissa Araujo da Paz, Luan Oliveira Ferreira, Esther Padilha da Silveira, Maria Klara Otake Hamoy, Nilton Akio Muto, Dielly Catrina Favacho Lopes, Moisés Hamoy   +9 more
wiley   +1 more source

Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis

mSphere, 2018
Cytochrome p4502E1 (CYP2E1) autoantibodies are biomarkers for drug-induced hepatitis and chronic hepatitis C. However, major histocompatibility-restricted CYP2E1 epitopes associated with these diseases have not been identified.
Elisa K. McCarthy, Amanda Vakos, Merylin Cottagiri, Joel J. Mantilla, Lakshmi Santhanam, David L. Thomas, L. Mario Amzel, Noel R. Rose, Dolores B. Njoku   +8 more
doaj   +1 more source

Expert Consensus on the Standardized Diagnosis, Treatment, and Management of Cancer in High‐Altitude Regions of China

Cancer Innovation, Volume 5, Issue 5, October 2026.
This expert consensus establishes standardized diagnostic, therapeutic, and management frameworks for cancers in high‐altitude regions of China, addressing epidemiological characteristics, tailored treatments, and highland‐specific adverse events to optimize care for plateau populations.
Yiqun Li, Feng Li, Xiaorong Bai, Yan Li, Chengyun Bai, Qiaomei Chang, Cuiping Guo, Ji Di, Qiuxia Dong, Mengting Da, Zhongcheng Li, Zhen Liu, Hongxia Liang, Yushuang Luo, Dengfeng Ren, Pengjie Yu, Rui Ma, Miaozhou Wang, Xueshan Zhao, Fuxing Zhao, Guoshuang Shen, Zhiping Feng, Hao Wang, Shengtao Zhou, Wenqiang Wei, Shanshan Chen, Lin Wang, Feng Du, Tseyang, Haifeng Xu, Xiaoling Ling, Gang Xu, Wei Guo, Yulan Zhao, Die Sang, Huachao Feng, Deqingwangmu, Gesangdeji, Basangdunzhu, Bianbazhaxi, Yixin Guo, Xinlong Tao, Guohui Bai, Wanpeng Yang, Hanhuan Luo, Yanming Lei, Cidanwangjiu, Fei Ma, Dong Wu, Jiuda Zhao   +49 more
wiley   +1 more source