Results 71 to 80 of about 15,252 (135)

Bielectrode Strategy for Determination of CYP2E1 Catalytic Activity: Electrodes with Bactosomes and Voltammetric Determination of 6-Hydroxychlorzoxazone

Biomedicines
We describe a bielectrode system for evaluation of the electrocatalytic activity of cytochrome P450 2E1 (CYP2E1) towards chlorzoxazone. One electrode of the system was employed to immobilize Bactosomes with human CYP2E1, cytochrome P450 reductase (CPR ...
Alexey V. Kuzikov, Rami A. Masamrekh, Tatiana A. Filippova, Anastasiya M. Tumilovich, Natallia V. Strushkevich, Andrei A. Gilep, Yulia Yu. Khudoklinova, Victoria V. Shumyantseva   +7 more
doaj   +1 more source

Amelioration of Acetaminophen-Induced Hepatic Oxidative Stress and Inflammation by RNAi Targeting Cyp2e1 In Vivo

Current Issues in Molecular Biology
The overdose of acetaminophen (APAP) has become the leading cause of acute liver failure in the United States and some Western countries. As a principal member of the cytochrome P450 enzymes (CYPs), CYP2E1 is a vital enzyme in regard to the production of
Wenwen Liu, Liwen Huan, Cai Zhang, Runting Yin, Zhen Ouyang, Yuan Wei   +5 more
doaj   +1 more source

Effect of SNPs in the Promoter Region on the Expression of Cytochrome P450 2E1 (CYP2E1) in Pig Liver

Animals
Boar taint, an unfavorable odor in the meat of intact male pigs, is caused primarily by the accumulation of two compounds: androstenone and skatole. This multifactorial trait is regulated by numerous dietary, management and genetic factors.
Holly Archer, Riani A. N. Soares, Mohsen Jafarikia, Brandon N. Lillie, Flavio Schenkel, E. James Squires   +5 more
doaj   +1 more source

Transgenic plants of Petunia hybrida harboring the CYP2E1 gene efficiently remove benzene and toluene pollutants and improve resistance to formaldehyde

Genetics and Molecular Biology, 2011
The CYP2E1 protein belongs to the P450 enzymes family and plays an important role in the metabolism of small molecular and organic pollutants. In this study we generated CYP2E1 transgenic plants of Petunia using Agrobacterium rhizogenes K599.
Daoxiang Zhang, Taihe Xiang, Li Peihan, Lumin Bao   +3 more
doaj  

Folic acid protects against isoniazid-induced liver injury via the m6A RNA methylation of cytochrome P450 2E1 in mice

Frontiers in Nutrition
BackgroundCytochrome P450 2E1 (CYP2E1) converts isoniazid (INH) to toxic metabolites and is critical in INH-induced liver injury. The aim is to investigate the effect of folic acid (FA) on CYP2E1 and INH-induced liver injury.MethodsMale Balb/c mice were ...
Lan Jiang, Ya Ni, Cong Zhao, Dexin Gao, Xiaochun Gai, Ke Xiong, Jinyu Wang   +6 more
doaj   +1 more source

Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries

Cell Reports
Summary: Hepatocytes are organized into distinct zonal subsets across the liver lobule, yet their contributions to liver homeostasis and regeneration remain controversial. Here, we developed multiple genetic lineage-tracing mouse models to systematically
Chow Hiang Ang, Philip Arandjelovic, Jinming Cheng, Jicheng Yang, Fusheng Guo, Yuanquan Yu, Sarmilla Nelameham, Lachlan Whitehead, Jiangtao Li, David L. Silver, Nick Barker, Jane E. Visvader, Pierce K.H. Chow, Gordon K. Smyth, Yunshun Chen, David M. Virshup, Nai Yang Fu   +16 more
doaj   +1 more source

Alcohol and cancer: the role of cytochrome P-4502E1

Nutrimentum et Curae
Chronic alcohol consumption is a risk factor for tumours of the oral cavity, pharynx, larynx, oesophagus, liver, colorectum and the female breast. Various mechanisms contribute to alcohol-mediated carcinogenesis, including the action of cytochrome P ...
Helmut K. Seitz, Bernardo Moreira, Manuela Neuman   +2 more
doaj   +1 more source

Unraveling the Role of CYP2E1 in Antitubercular Drug–Induced Hepatotoxicity: From Molecular Mechanisms to Clinical Implications

International Journal of Hepatology
Antitubercular (AT) drugs, particularly isoniazid (INH), rifampicin (RIF), pyrazinamide (PYZ), and ethambutol (EMB), are the cornerstone of tuberculosis (TB) treatment.
Debasree Bishnu, Suman Santra, Swagata Purkait, Amal Santra   +3 more
doaj   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science
Obesity is a major global health challenge characterized by chronic low‐grade inflammation and impaired mitochondrial homeostasis. Although cytochrome P450 2E1 (CYP2E1) is implicated in oxidative stress and inflammatory signaling, its contribution to ...
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
doaj   +1 more source

Effects of <i>CYP2E1</i> Polymorphism and Dietary Supplementation With Jerusalem Artichoke on Skatole and Indole Levels in the Back Fat and Feces of Boars, and Liver mRNA Expression. [PDF]

Food Sci Nutr
Zadinová K, Stratil A, Čítek J, Okrouhlá M, Calta J, Bahelka I, Urbancová K, Šprysl M, Stupka R.   +8 more
europepmc   +1 more source