Results 61 to 70 of about 15,252 (135)

The role of cytochrome P450 2E1 on ethanol-mediated oxidative stress and HIV replication in human monocyte-derived macrophages

Biochemistry and Biophysics Reports, 2019
Background: Alcohol consumption is considered to be a major health problem among people living with HIV/AIDS. Our previous reports have shown that ethanol reduced intracellular concentrations of antiretroviral drugs elvitegravir and darunavir in the HIV ...
Yuqing Gong, P.S.S. Rao, Namita Sinha, Sabina Ranjit, Theodore J. Cory, Santosh Kumar   +5 more
doaj   +1 more source

CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K/AKT Pathway

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Epithelial ovarian cancer (EOC) frequently disseminates within the lipid‐rich peritoneal cavity, where tumor progression is accompanied by metabolic adaptations involving lipid utilization and mitochondrial function. Although these metabolic alterations are increasingly recognized as important features of EOC progression and ...
Lixue Cao, Yanzhen Chen, Yingqi Liu, Changnian Yang, Zhentao Zhang, Yongqing Lin, Yiyuan Wang, Siman Chen, Fei Yu, Haiyan Ye, Shanshan Wu   +10 more
wiley   +1 more source

Comparative Evaluation of Ethanolic Extracts Obtained From the Seeds of White and Black Açai Exhibit Antioxidant and Cytoprotective Activity In Vitro

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Açai seed extracts (black/white) showed antioxidant activity (black ∼30% stronger), no cytotoxicity or genotoxicity, and transient cytoprotection in normal and cancer cell lines. Black extract (200 µg/mL) inhibited colony formation without reducing cisplatin efficacy. Phenolic‐rich seed waste warrants further therapeutic study. ABSTRACT The açai fruit (
Luana França Calandrini de Azevedo, Estanislaw Tairowite Prestes Correa, Hemilly Casanova Gonçalves Soeiro, Oscar Vinícius Moraes dos Santos, Gustavo Henrique da Silva Lopes, Karina Motta Melo, Vinicius Silva de Carvalho, Andryo Orfi de Almada Vilhena, Jorge das Dores Rissino, Karen Albuquerque Dias da Costa, Alberdan da Silva Santos, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka   +12 more
wiley   +1 more source

Harnessing Terminalia arjuna in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee, Fahika Nazeerulla, Manash Kumar Paul, Sujit Kumar Bhutia, Deblina Basu, Subhadip Mukhopadhyay   +5 more
wiley   +1 more source

Cytochrome P450 2E1 aggravates DXR-induced myocardial injury through imbalanced mitochondrial OPA1

Cell Communication and Signaling
Background Cytochrome P450 2E1 (CYP2E1), a drug metabolism enzyme, is linked to multiple pathophysiological states in the myocardium and may act as a sensor of heart diseases.
Jiaxin Ma, Yaheng Wang, Huijiao Lv, Yu Lei, Feifei Guan, Wei Dong, He Wang, Lianfeng Zhang, Dan Lu   +8 more
doaj   +1 more source

Q11, a CYP2E1 inhibitor, exerts anti-hepatocellular carcinoma effect by inhibiting M2 macrophage polarization

Cancer Immunology, Immunotherapy
Despite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is upregulated in M2 macrophages.
Cunzhen Zhang, Yan Fang, Mengxue Guo, Liming Tang, Yurong Xing, Jun Zhou, Yuanyuan Guo, Yuhan Gu, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +11 more
doaj   +1 more source

CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells

Molecular Medicine
Background Increased level of serum cholic acid (CA) is often accompanied with decreased CYP2E1 expression in hepatocellular carcinoma (HCC) patients. However, the roles of CA and CYP2E1 in hepatocarcinogenesis have not been elucidated.
Zhiwei Hao, Xuemin Liu, Huanhuan He, Zhixuan Wei, Xiji Shu, Jianzhi Wang, Binlian Sun, Hongyan Zhou, Jiucheng Wang, Ying Niu, Zhiyong Hu, Shaobo Hu, Yuchen Liu, Zhengqi Fu   +13 more
doaj   +1 more source

Dynamic CYP2E1 expression and metabolic activity changes in male rats during immune liver injury and sex differences in alcohol metabolism.

PLoS ONE
Previous studies conducted by our team have demonstrated that CYP2E1 expression is downregulated during Bacillus Calmette-Guérin (BCG)-induced immune liver injury (hepatitis).
Jiayi Zhang, Yingying Cao, Ziqi Jin, Runa A, Xiaoxue Wang, Lingyu Zhang, Yingqi Hu, Yongzhi Xue   +7 more
doaj   +1 more source

Targeting of CYP2E1 by miRNAs in alcohol-induced intestine injury

Molecules and Cells
: Although binge alcohol-induced gut leakage has been studied extensively in the context of reactive oxygen species−mediated signaling, it was recently revealed that post-transcriptional regulation plays an essential role as well.
Hyejin Mun, Sungyul Lee, Suyoung Choi, Ji-Hoon Jeong, Seungbeom Ko, Yoo Lim Chun, Benjamin Deaton, Clay T. Yeager, Audrey Boyette, Juliana Palmera, London Newman, Ping Zhou, Soona Shin, Dong-Chan Kim, Cari A. Sagum, Mark T. Bedford, Young-Kook Kim, Jaeyul Kwon, Junyang Jung, Jeong Ho Chang, Je-Hyun Yoon   +20 more
doaj   +1 more source

A comprehensive study of CYP2E1 and its role in carcass characteristics and chemical lamb meat quality in different Indonesian sheep breeds.

PLoS ONE
The role of CYP2E1 in oxidation is essential for its effects on meat quality. This study used 200 Indonesian sheep (Ovis aries) to determine the SNP g allele frequencies. g.
Ratna Sholatia Harahap, Asep Gunawan, Yuni Cahya Endrawati, Huda Shalahudin Darusman, Göran Andersson, Ronny Rachman Noor   +5 more
doaj   +1 more source