Results 211 to 220 of about 2,499,952 (347)

Heterologous Overexpression of Cytochrome P450BM3 from <i>Bacillus megaterium</i> and Its Role in Gossypol Reduction. [PDF]

Toxins (Basel)
Fan W, Cui J, Xu T, Xu S, Ainiwaer Z, Luo Q, Wang C.   +6 more
europepmc   +1 more source

Biomedical Applications of Nanozymes: An Enzymology Perspective

Angewandte Chemie, EarlyView.
With a lens of enzymology, this review compares nanozymes with enzymes using the Michaelis‐Menten model and differences in KM and kcat along with catalysis in complex biological environment. The implications of these differences in biomedical applications of nanozymes are then described with a statistical analysis of the trend of therapeutic use of ...
Vasily G. Panferov, Xiaohan Zhang, Ka‐Ying Wong, Jung Heon Lee, Juewen Liu   +4 more
wiley   +2 more sources

Vitamin D‐induced mechanisms in cancer prevention and therapy: Recent advances and future opportunities

Animal Models and Experimental Medicine, EarlyView.
Vitamin D, traditionally known to promote calcium and bone health, is being explored for its role in cancer prevention and treatment through its influence on cell proliferation, differentiation, apoptosis, and immune response. The vitamin D receptor (VDR) regulates gene expression and interacts with key signaling pathways such as Wnt/β‐catenin, MAPK ...
D. Prasanth, Pathan Amanulla Khan, Jamal‐E‐Fatima, Trupti Pratik Durgawale, Falak Arjumand Siddique, Sharuk L. Khan, Azmath Farhana, Uttam Prasad Panigrahy, Mohammed Abdul Aziz shahid, Mohammed Sayeed, Md. Faysal   +10 more
wiley   +1 more source

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]

Basic Clin Pharmacol Toxicol
Wang F, Gu X, Hong H, Xia Q, Zhang Y, Song Y, Li B, Fan P.   +7 more
europepmc   +1 more source

Mechanistic Divergence in Sulfur‐Ligated Iron(III)‐Alkylperoxo Reactivity: Aldehyde Oxidation Prevails over Deformylation

Angewandte Chemie, EarlyView.
This study explores the mechanistic investigation into an unusual reactivity of a thioether‐ligated low‐spin Fe(III)‐alkylperoxide with cyclohexane–carboxaldehyde as a mimic of nonheme iron(II) enzyme intermediates and highlights that only efficient catalysis happens from a high‐valent iron(IV)‐oxo species.
Jagnyesh K. Satpathy, Rolly Yadav, Payal Panwar, Vijaya Thangaraj, Maheswaran Shanmugam, Chivukula V. Sastri, Sam P. de Visser   +6 more
wiley   +2 more sources

Development of primers for the mitochondrial cytochrome c oxidase I gene in digenetic trematodes (Platyhelminthes) illustrates the challenge of barcoding parasitic helminths

Molecular Ecology Resources, 2009
A. Moszczynska, S. Locke, J. D. Mclaughlin, D. Marcogliese, T. Crease   +4 more
semanticscholar   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source

Scutellarin suppresses Mycobacterium tuberculosis-induced pyroptosis in macrophages by inhibiting the HIF-1α-mediated Warburg effect. [PDF]

Redox Rep
Wu J, Liu F, Shen J, Zhang H, Liu Y, Sun J, Yang G, Zheng Y, Jiang X.   +8 more
europepmc   +1 more source

Breaking the Linear Scaling Relations for the Oxygen Reduction Reaction with a Dual‐Atom Catalyst Composed of a MnFe‐Porphyrrole Aerogel

Angewandte Chemie, EarlyView.
A bioinspired MnFe porphyrrole aerogel catalyst is synthesized using a covalent 3D framework with adjacent metal centers. The bimetallic structure enhances ORR activity through Mn─Fe synergy and high active site density. Fuel cell tests show over a 30% increase in peak power density, with DFT calculations confirming metal–metal charge transfer as the ...
Eliana Lebowitz, Prasenjit Das, Łukasz Kielesiński, Leigh Peles‐Strahl, David A. Cullen, Ilya Grinberg, Daniel T. Gryko, Lior Elbaz   +7 more
wiley   +2 more sources

Cytochrome c Biogenesis: Mechanisms for Covalent Modifications and Trafficking of Heme and for Heme-Iron Redox Control

Microbiology and Molecular Biology Reviews, 2009
R. Kranz, Cynthia L. Richard-Fogal, John-Stephen A Taylor, E. Frawley   +3 more
semanticscholar   +1 more source