Results 1 to 10 of about 101,216 (235)
CHI3L1 promotes cell division through activation of RhoA in lung cancer cells [PDF]
Cell Communication and SignalingBackground Cytokinesis, the final stage of cell division, is crucial for maintaining genomic stability. Dysregulation of cytokinesis can contribute to cancer development. This study aimed to investigate the role of CHI3L1 in cytokinesis and its influence
Ji Eun Yu +9 more
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mSphere, 2022 Cytokinesis in Trypanosoma brucei occurs unidirectionally from the anterior toward the posterior through mechanisms distinct from those of its human host and is controlled by a signaling pathway comprising evolutionarily conserved and trypanosome ...
Yasuhiro Kurasawa +2 more
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The number of cytokinesis nodes in mitotic fission yeast scales with cell size
eLife, 2022 Cytokinesis nodes are assemblies of stoichiometric ratios of proteins associated with the plasma membrane, which serve as precursors for the contractile ring during cytokinesis by fission yeast.
Wasim A Sayyad, Thomas D Pollard
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Targeting cytokinesis bridge proteins to kill high-CIN type tumors
Fundamental Research, 2021 As a common feature of tumors, chromosomal instability (CIN) not only forces carcinomatous evolution, but also loads cancer cells with extra pressure through a robust imbalance of genome patterning that may be used for cancer treatment.
Bingteng Xie +11 more
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Genes & Development, 2009 Cytokinesis is the terminal step of the cell cycle during which a mother cell divides into daughter cells. Often, the machinery of cytokinesis is positioned in such a way that daughter cells are born roughly equal in size. However, in many specialized cell types or under certain environmental conditions, the cell division machinery is placed at ...
Oliferenko, Snezhana +2 more
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Open Biology, 2022 Cytokinesis in eukaryotes is regulated by a Polo-like kinase-mediated and Aurora B kinase-mediated signalling pathway that promotes the assembly of the actomyosin contractile ring, a cytokinesis machinery conserved across evolution from yeast to humans ...
Yasuhiro Kurasawa +4 more
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Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. [PDF]
PLoS Genetics, 2014 Cytokinesis terminates mitosis, resulting in separation of the two sister cells. Septins, a conserved family of GTP-binding cytoskeletal proteins, are an absolute requirement for cytokinesis in budding yeast.
Manoj B Menon +12 more
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Anillin Phosphorylation Controls Timely Membrane Association and Successful Cytokinesis. [PDF]
PLoS Genetics, 2017 During cytokinesis, a contractile ring generates the constricting force to divide a cell into two daughters. This ring is composed of filamentous actin and the motor protein myosin, along with additional structural and regulatory proteins, including ...
Hyunjung Kim +4 more
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Uncoupling cell division and cytokinesis during germline development in metazoans
Frontiers in Cell and Developmental Biology, 2022 The canonical eukaryotic cell cycle ends with cytokinesis, which physically divides the mother cell in two and allows the cycle to resume in the newly individualized daughter cells.
Abigail R. Gerhold +4 more
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Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. [PDF]
PLoS ONE, 2016 Nuclear distribution protein C (NudC) is a mitotic regulator that plays a role in cytokinesis. However, how NudC is regulated during cytokinesis remains unclear. Here, we show that NudC is phosphorylated by Aurora B, a kinase critical for cell abscission.
Kimberly N Weiderhold +7 more
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