Results 101 to 110 of about 85,479 (195)
The Role of Diaphanous in Ring Canal Development in Drosophila melanogaster [PDF]
, 2016 Infertility is a widespread condition that does not always have a known cause, and for which we often do not have a cure. One potential cause of infertility is defects in gametogenesis, or the formation of sperm and egg.
Kindred, Alexandra M.
core +1 more source
Cell Proliferation, Volume 58, Issue 4, April 2025.Diagram illustrating the impact of OEM on oocyte‐cumulus communication, showing reduced TZPs, mitochondrial dysfunction, increased oxidative stress, DNA damage, and apoptosis. Melatonin (MLT) treatment improves communication, enhances mitochondrial function, reduces DNA damage, and restores oocyte quality, offering insights into potential therapeutic ...
Lei Ge +11 more
wiley +1 more source
TRAPPC2l Participates in Male Germ Cell Development by Regulating Cell Division
Cell Proliferation, EarlyView.Trappc2l is crucial for maintaining the quiescent state of male gonocytes. In the absence of Trappc2l, the quiescent state of gonocytes is disrupted, leading to premature and abnormal initiation of meiosis, which consequently results in subsequent abnormalities in sperm development. ABSTRACT TRAPPC2L is a core subunit of the Transport Protein Particle (
Mengyue Wang +8 more
wiley +1 more source
SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. [PDF]
, 2008 Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on ...
Dammermann, Alexander +3 more
core +1 more source
Exploring the Single‐Cell Dynamics of FOXM1 Under Cell Cycle Perturbations
Cell Proliferation, EarlyView.The varied FOXM1 dynamic patterns reveal significant differences in cellular responses to the same stimuli at the single‐cell level. This emphasises the relationship between cue, signal and response as influenced by different drug types and concentrations.
Tooba Jawwad +6 more
wiley +1 more source
Cell Proliferation, EarlyView.This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan +5 more
wiley +1 more source
The FEBS Journal, Volume 292, Issue 9, Page 2173-2188, May 2025.Mitogen‐activated protein kinases (MAPKs) regulate various cellular processes, including proliferation, differentiation, and motility. Alterations in these signalling pathways can lead to various diseases, including cancer. The atypical MAPKs ERK3 (MAPK6), ERK4 (MAPK4), ERK7/8 (MAPK15) and NLK have long been neglected in kinomic studies.
Katrin Dahm +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Mice and mouse embryonic fibroblasts homozygous for an Actg1 allele edited to translate β‐actin instead of γ‐actin (Actg1‐coding beta) are devoid of γ‐actin protein. We demonstrate that these Actg1c‐b/c‐b mice present with no measurable phenotype in survival, body mass, activity, muscle contractility, or auditory function.
Lauren J. Sundby +7 more
wiley +1 more source
Histopathology, Volume 86, Issue 6, Page 916-932, May 2025.This study investigates threonine and tyrosine kinase (TTK) expression in pre‐ and post‐neoadjuvant chemotherapy breast cancer patients. TTK mRNA expression was elevated in breast cancer tissues, predicting reduced survival. Notably, TTK protein expression in neoadjuvant chemotherapy‐treated breast cancer patients was up‐regulated post‐therapy and ...
Abrar Ashi +5 more
wiley +1 more source