A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome [PDF]
HereditasBackground The dynein cytoplasmic two heavy chain 1 (DYNC2H1) gene encodes a cytoplasmic dynein subunit. Cytoplasmic dyneins transport cargo towards the minus end of microtubules and are thus termed the “retrograde” cellular motor.
Sujie Xiong +4 more
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Structure and Function of Dynein’s Non-Catalytic Subunits [PDF]
CellsDynein, an ancient microtubule-based motor protein, performs diverse cellular functions in nearly all eukaryotic cells, with the exception of land plants.
Lu Rao, Arne Gennerich
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Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein
Scientific Reports, 2022 Eukaryotic cilia/flagella are cellular bio-machines that drive the movement of microorganisms. Molecular motor axonemal dyneins in the axoneme, which consist of an 9 + 2 arrangement of microtubules, play an essential role in ciliary beating.
Shin Yamaguchi +2 more
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The Generation of Dynein Networks by Multi-Layered Regulation and Their Implication in Cell Division
Frontiers in Cell and Developmental Biology, 2020 Cytoplasmic dynein-1 (hereafter referred to as dynein) is a major microtubule-based motor critical for cell division. Dynein is essential for the formation and positioning of the mitotic spindle as well as the transport of various cargos in the cell.
Takayuki Torisawa +3 more
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Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Cytoplasmic dynein complex is a large multi-subunit microtubule (MT)-associated molecular motor involved in various cellular functions including organelle positioning, vesicle transport and cell division.
Takuya Kobayashi, Takashi Murayama
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FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex.
PLoS Genetics, 2022 Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Limei Wang +3 more
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Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
eLife, 2020 Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee +8 more
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Genetic analysis of the cytoplasmic dynein subunit families.
PLoS Genetics, 2006 Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of ...
K Kevin Pfister +7 more
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eLife, 2017 Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-
Jonathan B Steinman +21 more
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Spatio-temporal regulation of nuclear division by Aurora B kinase Ipl1 in Cryptococcus neoformans. [PDF]
PLoS Genetics, 2019 The nuclear division takes place in the daughter cell in the basidiomycetous budding yeast Cryptococcus neoformans. Unclustered kinetochores gradually cluster and the nucleus moves to the daughter bud as cells enter mitosis.
Neha Varshney +6 more
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