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Nuclear migration: Cortical anchors for cytoplasmic dynein [PDF]

Current Biology, 2021
Nuclear migration in yeast provides a model system for studying how a cell polarizes the actin and microtubule cytoskeletons toward sites of cell growth. Recent findings indicate that cortical anchors are necessary for directing microtubule-based processes.
Kerry Bloom
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Structure and Function of Dynein’s Non-Catalytic Subunits [PDF]

Cells
Dynein, an ancient microtubule-based motor protein, performs diverse cellular functions in nearly all eukaryotic cells, with the exception of land plants.
Lu Rao, Arne Gennerich
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A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome [PDF]

Hereditas
Background The dynein cytoplasmic two heavy chain 1 (DYNC2H1) gene encodes a cytoplasmic dynein subunit. Cytoplasmic dyneins transport cargo towards the minus end of microtubules and are thus termed the “retrograde” cellular motor.
Sujie Xiong, Guangyao Hu, Yao Zhou, Fei Sun, Yanlin Ma   +4 more
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Genetic analysis of the cytoplasmic dynein subunit families.

PLoS Genetics, 2006
Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of ...
K Kevin Pfister, Paresh R Shah, Holger Hummerich, Andreas Russ, James Cotton, Azlina Ahmad Annuar, Stephen M King, Elizabeth M C Fisher   +7 more
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Reconstitution of the human cytoplasmic dynein complex [PDF]

Proceedings of the National Academy of Sciences, 2012
Cytoplasmic dynein is the major motor protein responsible for microtubule minus-end–directed movements in most eukaryotic cells. It transports a variety of cargoes and has numerous functions during spindle assembly and chromosome segregation.
Martina Trokter, Norbert Mücke, Thomas Surrey   +2 more
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Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein

Scientific Reports, 2022
Eukaryotic cilia/flagella are cellular bio-machines that drive the movement of microorganisms. Molecular motor axonemal dyneins in the axoneme, which consist of an 9 + 2 arrangement of microtubules, play an essential role in ciliary beating.
Shin Yamaguchi, Masahiko Yamagishi, Junichiro Yajima   +2 more
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Cytoplasmic dynein nomenclature [PDF]

The Journal of Cell Biology, 2005
A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes.
Pfister, K. Kevin, Fisher, Elizabeth M. C., Gibbons, Ian R., Hays, Thomas S., Holzbaur, Erika L. F., McIntosh, J. Richard, Porter, Mary E., Schroer, Trina A., Vaughan, Kevin T., Witman, George B., King, Stephen M., Vallee, Richard B.   +11 more
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Cytoplasmic dynein-2 at a glance [PDF]

Journal of Cell Science, 2020
ABSTRACT Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function, as evidenced by deleterious mutations in patients with skeletal abnormalities ...
Laura Vuolo, Nicola L. Stevenson, Aakash G. Mukhopadhyay, Anthony J. Roberts, David J. Stephens   +4 more
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Cytoplasmic factories for axonemal dynein assembly [PDF]

Journal of Cell Science, 2021
ABSTRACT Axonemal dyneins power the beating of motile cilia and flagella. These massive multimeric motor complexes are assembled in the cytoplasm, and subsequently trafficked to cilia and incorporated into the axonemal superstructure. Numerous cytoplasmic factors are required for the dynein assembly process, and, in mammals, defects lead
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The Generation of Dynein Networks by Multi-Layered Regulation and Their Implication in Cell Division

Frontiers in Cell and Developmental Biology, 2020
Cytoplasmic dynein-1 (hereafter referred to as dynein) is a major microtubule-based motor critical for cell division. Dynein is essential for the formation and positioning of the mitotic spindle as well as the transport of various cargos in the cell.
Takayuki Torisawa, Takayuki Torisawa, Akatsuki Kimura, Akatsuki Kimura   +3 more
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