Results 41 to 50 of about 4,251 (182)

Force-Induced Bidirectional Stepping of Cytoplasmic Dynein [PDF]

Cell, 2007
Cytoplasmic dynein is a minus-end-directed microtubule motor whose mechanism of movement remains poorly understood. Here, we use optical tweezers to examine the force-dependent stepping behavior of yeast cytoplasmic dynein. We find that dynein primarily advances in 8 nm increments but takes other sized steps (4-24 nm) as well. An opposing force induces
Gennerich, Arne, Carter, Andrew P., Reck-Peterson, Samara L., Vale, Ronald D.   +3 more
openaire   +2 more sources

The C‐Terminal Regions of TRAK Proteins Contain MIRO‐Independent Mitochondrial Localization Domains

Cytoskeleton, EarlyView.
ABSTRACT Current models suggest that MIRO GTPases anchor cytoskeletal motors to the mitochondrial outer membrane (MOM). However, our previous findings indicate that the unconventional myosin, MYO19, interacts with MIRO weakly and that a MIRO‐independent MOM‐localizing domain interacts more tightly with the MOM.
Lili Mitchell, Kathryn E. Reda, Hijab Fatima, Claudia E. Vasquez, Omar A. Quintero‐Carmona   +4 more
wiley   +1 more source

Model for bidirectional movement of cytoplasmic dynein [PDF]

Journal of Theoretical Biology, 2015
Cytoplasmic dynein exhibits a directional processive movement on microtubule filaments and is known to move in steps of varying length based on the number of ATP molecules bound to it and the load that it carries. It is experimentally observed that dynein takes occasional backward steps and the frequency of such backward steps increases as the load ...
Sumathy, S., Satyanarayana, S. V. M.
openaire   +4 more sources

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Active Transport by Cytoplasmic Dynein Maintains the Localization of MAP2 in Developing Neurons [PDF]

, 2023
Yoji Yonemura, Yuri Sakai, Rinaho Nakata, Ayaka Hagita-Tatsumoto, Tomohiro Miyasaka, Hiroaki Misonou   +5 more
openalex   +1 more source

Molecular mechanism of cytoplasmic dynein tension sensing [PDF]

Nature Communications, 2019
AbstractCytoplasmic dynein is the most complex cytoskeletal motor protein and is responsible for numerous biological functions. Essential to dynein’s function is its capacity to respond anisotropically to tension, so that its microtubule-binding domains bind microtubules more strongly when under backward load than forward load.
Lu Rao, Florian Berger, Matthew P. Nicholas, Arne Gennerich   +3 more
openaire   +3 more sources

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Sequence and expression analysis of potential spermatogenesis‐specific gene cognates in the Caribbean fruit fly, Anastrepha suspensa

Insect Science, EarlyView.
Abstract The sterile insect technique (SIT) is a highly effective biologically‐based method for the suppression of many insect pest populations. SIT efficacy could be improved by methods of male sterilization that avoid the use of irradiation that can result in diminished fitness and mating competitiveness.
Alfred M. Handler, Richard B. Furlong, Chao Chen, Daniel A. Hahn   +3 more
wiley   +1 more source